Hematological inflammatory biomarkers affecting the success rate of in vitro fertilization among cases of unexplained infertility Short running title: Hematological biomarkers and IVF outcome

Endometriosis is a very common debilitating disease that occurs in 6 to 10 percent of the general female population; in women with pain, infertility, or both, the frequency is 35–50%. Endometriosis is one of the most important causes of infertility. Our objective is to evaluate the effect of endometriosis and adenomyosis on IVF outcome (ongoing pregnancy). 65 women underwent In Vitro Fertilization (IVF) and embryos transfer who had endometriosis with or without adenomyosis were recruited in this retrospective study, resulting in 53.8% had a successful IVF attempt (get pregnant). The highest success rate of IVF was in women who were in mild of endometriosis and IVF failure rate was increased mainly in women who were in severe endometriosis. So, the presence of adenomyosis affects IVF outcome and decreases the rate of implantation.

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Prevalence of Common Thrombophilia and Antiphospholipid Antibodies in Unexplained Infertility Women Undergoing in Vitro Fertilization (IVF)

Blood ◽

10.1182/blood.v120.21.628.628 ◽

2012 ◽

Vol 120 (21) ◽

pp. 628-628

Author(s):

Arie Steinvil ◽

Raanan Raz ◽

Shlomo A. Berliner ◽

David M Steinberg ◽

David Zeltser ◽

...

Keyword(s):

In Vitro Fertilization ◽

Success Rate ◽

Conflicts Of Interest ◽

Factor V Leiden ◽

Unexplained Infertility ◽

Factor V ◽

Vitro Fertilization ◽

History Of ◽

The Mean

Abstract Abstract 628 Assisted reproductive technology (ART) is extensively used as a tool for pregnancy achievement in subfertile couples. Congenital and acquired thrombophilia have been suggested by some investigators to play a role in abnormal embryos implantation and placentation. The objective of this study was to assess the role of common thrombophilia in women with unexplained infertility undergoing in vitro fertilization (IVF). We enrolled five hundred ninety-four women from a large healthcare maintenance organization going through IVF and who had a thrombophilia workup, and compared them for prevalence of thrombophilia to two reference groups consisting of 637 fertile women from previous work and 17,337 women members of the same healthcare organization with no history of venous thromboembolisms. The mean age of the women at the first cycle of IVF was 30.9 years (SD: ±4.1).The mean number of IVF cycles was 7.3 (SD: 5.0), and the mean fertility success rate per woman was 14.6% (SD: 19.0). None of the common thrombophilia tested was found to be significantly associated with the number of IVF cycles or with lower fertility success rate. Rather, women who had APCR and/or factor V Leiden and lupus anticoagulant had significantly higher live birth rates (12.25% and 12.64%, respectively) in comparison to women who were tested negative (8.98% and 9.7%, respectively). Thus, hypercoagulability is not associated with failure to achieve pregnancy. These data suggest that neither screening for thrombophilia nor anticoagulant treatment is indicated in cases with unexplained reproductive failure. Disclosures: No relevant conflicts of interest to declare.

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The influence of ovulation induction by human menopausal gonadotropin on uterine blood flow in unexplained infertility compared to mechanical infertility in patients undergoing in-vitro fertilization treatment

Journal of the Society for Gynecologic Investigation ◽

10.1016/1071-5576(95)94578-i ◽

1995 ◽

Vol 2 (2) ◽

pp. 375

Author(s):

A GROUTZ

Keyword(s):

Blood Flow ◽

In Vitro Fertilization ◽

Ovulation Induction ◽

Unexplained Infertility ◽

Human Menopausal Gonadotropin ◽

Uterine Blood Flow ◽

Vitro Fertilization

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Detection of chlamydia trachomatis by pcr in culture negative women and relation to in vitro fertilization (IVF) outcome

Journal of the Society for Gynecologic Investigation ◽

10.1016/1071-5576(95)94575-f ◽

1995 ◽

Vol 2 (2) ◽

pp. 374

Author(s):

S WITKIN

Keyword(s):

In Vitro Fertilization ◽

Chlamydia Trachomatis ◽

Ivf Outcome ◽

Vitro Fertilization ◽

Culture Negative

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The Role of Laparoscopic Investigation in Enabling Natural Conception and Avoiding in vitro Fertilization Overuse for Infertile Patients of Unidentified Aetiology and Recurrent Implantation Failure Following in vitro Fertilization

Journal of Clinical Medicine ◽

10.3390/jcm8040548 ◽

2019 ◽

Vol 8 (4) ◽

pp. 548 ◽

Cited By ~ 5

Author(s):

Agni Pantou ◽

Mara Simopoulou ◽

Konstantinos Sfakianoudis ◽

Polina Giannelou ◽

Anna Rapani ◽

...

Keyword(s):

Laparoscopic Surgery ◽

In Vitro Fertilization ◽

Primary Outcome ◽

Unexplained Infertility ◽

Vitro Fertilization ◽

Natural Conception ◽

Infertility Patients ◽

Infertile Patients

The present study aims to explore the effectiveness of laparoscopic surgery on women presenting with infertility, of unidentified aetiology according to the standard infertility investigation, and recurrent failed In Vitro Fertilization (IVF) attempts. Identifying and correcting possible underlying pathologies by laparoscopy may subsequently enable natural conception in an effort to address infertility and avoid IVF overuse. One-hundred and seven (107) women with unidentified aetiology of infertility and recurrent failed IVF attempts met the inclusion criteria. Laparoscopic surgery was performed as the endpoint of the patients’ diagnostic journey, aiming to identify a possible underlying factor as the cause of infertility. Sixty-two (62) out of 107 patients (57.94%) that underwent laparoscopy were diagnosed with endometriosis, 25 out of the 107 patients (23.3%) were diagnosed with periadnixal and pelvic adhesions, and 20 cases (18.69%) presented with no pathology and remained unexplained. Following identification and correction of endometriosis and pelvic adhesions, patients were invited to conceive naturally. For the patients that laparoscopic investigation failed to reveal any pathology they were categorized as unexplained infertility and were subjected to a single IVF cycle. Natural conception success rate within the first postoperative year was the primary outcome. Within the first postoperative year, 30 out of 62 patients (48.38%) diagnosed with endometriosis following laparoscopic investigation achieved a natural conception, and 28 out of them (93.4%) reported live-births. Additionally, 11 out of 25 patients (44%) diagnosed with periadnixal and pelvic adhesions achieved natural conception within the first operative year. Regarding the group of unexplained infertility patients, only four out of the 20 patients (20%) achieved clinical pregnancy in the first post-operative IVF cycle. In conclusion, laparoscopy appears to be a promising approach, addressing infertility, providing significant diagnostic findings, while avoiding IVF overuse regarding patients of unidentified infertility presenting with recurrent failed IVF attempts.

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