Background:
Prevalence and the risk of common antiphospholipid antibodies (aPLs) such as lupus
anticoagulant (LA), anticardiolipin (aCL) and anti-β2-glycoprotein I (β2-GPI) antibodies in preeclampsia is a matter of
debate. Recently, interests have expanded in evaluating the risks of presenting non-classic aPLs in preeclampsia patients.
Objective:
The objective of this case-control study was to evaluate some haematological parameters besides assessing the
presence of anti-annexin A5 and antiphosphatidylinositol (aPI) antibodies in preeclampsia patients compared to nonpreeclampsia subjects.
Methods:
From two hospitals in Malaysia, a total of 84 subjects were recruited in this case-control study including 42
preeclampsia and 42 age-matched non-preeclampsia subjects. Some haematological parameters [i.e., haemoglobin, total
white blood cell, platelet, prothrombin time and activated partial thromboplastin time (APTT)] were assessed besides
screening for anti-annexin A5 and aPI antibodies.
Results:
Among the haematological parameters, APTT was significantly high in mild preeclampsia when compared to
severe preeclampsia subjects (p=0.007). IgG anti-annexin A5 antibody was detected in a single preeclampsia subject only
(2.4%) and none in non-preeclampsia subjects.
Conclusion:
Because of the low prevalence, non-classic aPLs should not be considered as a risk factor in developing
preeclampsia and not justifiable to consider as a routine assay in pregnant women.
CDPA-1 Stored Blood Induced Effect on some Haematological Parameters
