Endoscopic posterior nasal neurectomy in persistent allergic rhinitis: a clinical study

Recent studies show that perennial allergic rhinitis is prevalent among older people, but the management of this disease is underestimated and not determined. This article describes the persistent allergic rhinitis in patients of the older age group and identifies the primary goals of treatment based on the age-related physiological factors, concomitant conditions and the use of other drugs. Special attention is paid to the various options for the drug therapy in elderly patients over the age of 60 years. The second-generation antihistamines and intranasal glucocorticosteroids also have primacy over other drugs, when supervising older patients. A randomized open multicenter clinical study showed that Momate Rhino Advance (a combination of intranasal antihistamines (azelastine) and intranasal glucocorticosteroids (mometasone) for the treatment of allergic rhinitis) made by Indian Glenmark Pharmaceuticals Ltd. is effective and safe in patients aged 60 years and older, who are diagnosed with the above disease.

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Randomized prospective double-blind comparative clinical study of ebastine and its combined preparation of montelukast in persistent allergic rhinitis

National Journal of Physiology Pharmacy and Pharmacology ◽

10.5455/njppp.2018.8.0935522092017 ◽

2017 ◽

pp. 1

Author(s):

Rajashekar R ◽

Shobha N

Keyword(s):

Allergic Rhinitis ◽

Clinical Study ◽

Double Blind ◽

Persistent Allergic Rhinitis ◽

Comparative Clinical Study

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Topical nasal steroids for intermittent and persistent allergic rhinitis in children

10.1002/14651858.cd003163.pub3 ◽

2005 ◽

Author(s):

JJ Al Sayyad ◽

D Alhashimi ◽

Z Fedorowicz ◽

A Jamal

Keyword(s):

Allergic Rhinitis ◽

Persistent Allergic Rhinitis ◽

Nasal Steroids

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Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study

The Journal of Laryngology & Otology ◽

10.1017/s0022215121000967 ◽

2021 ◽

pp. 1-4

Author(s):

E Ocak ◽

S Mulazimoglu ◽

D Kocaoz ◽

E Mirici ◽

E Dagli ◽

...

Keyword(s):

Allergic Rhinitis ◽

Mucociliary Clearance ◽

Isotonic Saline ◽

Sodium Hyaluronate ◽

Controlled Study ◽

Control Group ◽

Clearance Time ◽

Nasal Irrigation ◽

Persistent Allergic Rhinitis ◽

Randomised Controlled

Abstract Objective To investigate the effects of nasal irrigation with sodium hyaluronate and surfactant solutions on mucociliary clearance time in patients with mild persistent allergic rhinitis. Methods A total of 120 patients diagnosed with mild persistent allergic rhinitis were enrolled in this prospective study. The patients were allocated randomly to the surfactant, sodium hyaluronate or isotonic saline (as a control) nasal irrigation group. The mucociliary clearance times and improvements in mucociliary clearance times were compared. Results Improvements in mean mucociliary clearance time were significantly greater in the surfactant and sodium hyaluronate groups than in the control group (p < 0.01). The mean post-treatment mucociliary clearance time of the surfactant group was significantly lower than that of the control (p < 0.001) and sodium hyaluronate groups (p = 0.03). Conclusion Surfactant and sodium hyaluronate nasal irrigation solutions may both be used as adjunctive treatments for allergic rhinitis. Surfactant nasal irrigation resulted in better mucociliary clearance times.

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Correlation of Nasal Fluid Biomarkers and Symptoms in Patients with Persistent Allergic Rhinitis

Annals of Otology Rhinology & Laryngology ◽

10.1177/0003489419898717 ◽

2020 ◽

Vol 129 (6) ◽

pp. 542-547

Author(s):

Su Il Kim ◽

Oh Eun Kwon ◽

Jung Min Park ◽

Jeon Gang Doo ◽

Seok Hyun Kim ◽

...

Keyword(s):

Allergic Rhinitis ◽

Inverse Correlation ◽

Lavage Fluid ◽

Nasal Symptom ◽

Clara Cell ◽

Cell Protein ◽

Enzyme Linked Immunosorbent Assay ◽

Prick Test ◽

Persistent Allergic Rhinitis ◽

Nasal Fluid

Objectives: This study investigated whether the biomarkers present in nasal fluid reflect the severity of symptoms in patients with persistent allergic rhinitis (PAR). Methods: We enrolled 29 PAR patients complaining of nasal symptoms and testing positive to skin prick test. Patients’ total nasal symptom score (TNSS) was measured and their nasal lavage fluid (NALF) was collected. The levels of biomarkers including Clara cell protein 16 (CC16), tryptase, and interleukin 5 (IL-5) in NALF were determined via enzyme-linked immunosorbent assay (ELISA). Results: PAR patients were classified into persistent mild and persistent moderate-to-severe groups according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. The CC16 alone was significantly negatively correlated with TNSS ( P < .05). Further, the CC16 level was significantly lower in persistent moderate-to-severe group than persistent mild group of patients ( P < .05). Conclusions: The levels of CC16 alone among several NALF biomarkers showed an inverse correlation with symptoms of PAR patients.

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