scholarly journals Role of Serum Leptin in the Diagnosis and Prognosis of Hepatocellular Carcinoma in Egyptian Cirrhotic Patients

2020 ◽  
Vol 88 (3) ◽  
pp. 259-266
Author(s):  
MOHAMED M. SALAMA, M.D.; AHMED S. ALLAM, M.D. ◽  
HAYTHAM M. NASSER, M.D.; WALAA A. YOUSRY KABIEL, M.D. ◽  
EHAB H. ELSAYED, M.D.
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Leptin ◽  
Diagnosis And Prognosis ◽  
Cirrhotic Patients

scholarly journals New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and Theragnostics

2021 ◽  
Vol 11 (3) ◽  
pp. 219
Author(s):  
Ya-Ling Yang ◽  
Yen-Hsiang Chang ◽  
Chia-Jung Li ◽  
Ying-Hsien Huang ◽  
Ming-Chao Tsai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Microenvironment ◽  
Crucial Role ◽  
Human Cancer ◽  
Metabolic Adaptation ◽  
Advanced Hcc ◽  
Diagnosis And Prognosis ◽  
Competitive Endogenous Rnas ◽  
Growing Body

Hepatocellular carcinoma (HCC) remains one of the most lethal human cancer globally. For advanced HCC, curable plan for advanced HCC is yet to be established, and the prognosis remains poor. The detail mechanisms underlying the progression of HCC tumorigenicity and the corruption of tumor microenvironment (TME) is complex and inconclusive. A growing body of studies demonstrate microRNAs (miRs) are important regulators in the tumorigenicity and TME development. Notably, mounting evidences indicate miR-29a play a crucial role in exerting hepatoprotective effect on various types of stress and involved in the progression of HCC, which elucidates their potential theragnostic implications. In this review, we reviewed the advanced insights into the detail mechanisms by which miR-29a dictates carcinogenesis, epigenetic program, and metabolic adaptation, and implicated in the sponging activity of competitive endogenous RNAs (ceRNA) and the TME components in the scenario of HCC. Furthermore, we highlighted its clinical significance in diagnosis and prognosis, as well as the emerging therapeutics centered on the activation of miR-29a.

scholarly journals Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patients

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Ahmed Elhosieny Ebrahim ◽  
Mona Ahmed Helmy Shehata ◽  
Sabry Abou-saif ◽  
Manal fathy Hamisa ◽  
Sherief Abd-Elsalam ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C ◽  
Early Detection ◽  
Cirrhotic Patients

scholarly journals Role of FBXL19-AS1 in hepatocellular carcinoma by lncRNA–miRNA–mRNA network analysis and its diagnostic and prognostic value

2020 ◽  
Author(s):  
Dingdong He ◽  
Xiaokang Zhang ◽  
Xinyu Zhu ◽  
Narayani Maharjan ◽  
Yingchao Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Clinical Value ◽  
Cerna Network ◽  
Diagnosis And Prognosis ◽  
Potential Biomarker ◽  
Viral Carcinogenesis ◽  
New Biomarkers ◽  
Diagnostic And Prognostic Value

Abstract Background: Hepatocellular carcinoma (HCC) is one of the most common neoplastic diseases worldwide. Available biomarkers are not sensitive enough for the diagnosis of HCC, seeking new biomarkers of HCC is urgent and challenging. The purpose of this study was to investigate the role of F-box and leucine-rich repeat protein 19-antisense RNA 1 (FBXL19-AS1) through competing endogenous RNA (ceRNA) network and its diagnostic and prognostic value in HCC.Methods: A comprehensive strategy of genomic data mining, bioinformatics and experimental validation was used to evaluate the clinical value of FBXL19-AS1 in the diagnosis and prognosis of HCC and to identify the pathways that FBXL19-AS1 may be involved in.Results: FBXL19-AS1 was up-regulated in HCC, and its high expression was associated with TNM stage and poor prognosis of HCC patients. The combined use of plasma FBXL19-AS1 and alpha-fetoprotein (AFP) could prominently improve the diagnostic validity for HCC. FBXL19-AS1 might participate in regulating HCC related pathways, including hepatitis C, hepatitis B, microRNAs in cancer, cell cycle, viral carcinogenesis, and proteoglycans in cancer through ceRNA network.Conclusions: Our findings indicated that FBXL19-AS1 not only serves as a potential biomarker for HCC diagnosis and prognosis, but it may be functionally carcinogenic.

scholarly journals Prognostic role of ABO blood group and Rhesus factor in cirrhotic patients with hepatocellular carcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alihan Oral ◽  
Tolga Sahin
Keyword(s):  
Hepatocellular Carcinoma ◽  
Blood Group ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Group ◽  
Rhesus Factor ◽  
Significant Difference ◽  
B Virus ◽  
Cirrhotic Patients

AbstractHepatocellular carcinoma (HCC) is one of the most common types of cancer worldwide. There are many factors in the etiology of HCC such as hepatitis B virus (HBV), hepatitis C virus (HCV), alcohol, obesity, smoking and aflatoxin. Many types of cancer are assumed to be associated with ABO blood group and Rhesus factor (RH). In this study we aimed to evaluate the relationship between tumor characteristics and overall survival (OS), ABO blood group and RH factor in patients with HCC. A total of 507 patients with chronic liver disease (252 patients with HCC and 255 patients without HCC) were included in the study. All demographic, clinic and laboratory (biochemical parameters and blood type) features were collected retrospectively. The mean age of the patients was 54.50 ± 9.30. There was no significant difference in both ABO groups and RH factors between the two groups. We found that vascular invasion rate of the tumor was higher in the B blood group and multicentric localization of tumor was significantly higer in patients with positive RH but there was no difference between OS in ABO and RH blood groups. In addition, the tumor was less multicentric in the AB blood group. Blood groups and RH factor can be used to predict the prognosis in cirrhotic patients with HCC.

scholarly journals Serum/Plasma MicroRNAs as Biomarkers for HBV-Related Hepatocellular Carcinoma in China

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Wen Yin ◽  
Yan Zhao ◽  
Yong-Jing Ji ◽  
Li-Ping Tong ◽  
Ya Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Regulation Of Gene Expression ◽  
Chinese Patients ◽  
Aberrant Expression ◽  
Diagnosis And Prognosis ◽  
Physiological Processes ◽  
Serum Mirnas ◽  
Proliferation And Differentiation ◽  
Plasma Mirnas

MicroRNAs (miRNAs) are a group of small RNAs with a fundamental role in the regulation of gene expression. These RNAs have been shown to participate in various cellular and physiological processes, including cellular development, apoptosis, proliferation, and differentiation. Aberrant expression of several miRNAs was found to be involved in a large variety of neoplasms, including hepatocellular carcinoma (HCC). Previous studies have shown the existence of a large amount of stable miRNAs in human serum/plasma, which laid the foundation for studying the role of serum/plasma miRNAs in the diagnosis and prognosis of HCC. Here, we review the recent progress in research on serum miRNAs as biomarkers for HCC in Chinese patients.

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