The Possible Biological Roles of KGF7/CTGF Growth Factor in Phenytoin and Cyclosporine-A Induced Gingival Overgrowth ; a Comparative Experimental Study

2015 ◽  
Vol 2 (6) ◽  
pp. 27-35
Keyword(s):  
Experimental Study ◽  
Growth Factor ◽  
Cyclosporine A ◽  
Gingival Overgrowth

Antioxidants protect against gingival overgrowth induced by cyclosporine A

2021 ◽  
Author(s):  
Yu‐Tang Chin ◽  
Hsiao‐Pei Tu ◽  
Chi‐Yu Lin ◽  
Po‐Jan Kuo ◽  
Hsien‐Chung Chiu ◽  
...  
Keyword(s):  
Cyclosporine A ◽  
Gingival Overgrowth

Impact of acute pulmonary embolism on plasma and tissue hepatocyte growth factor: an experimental study

2010 ◽  
Vol 36 (4) ◽  
pp. 237-242 ◽  
Author(s):  
Yi-Bo Li ◽  
Ming-Ting Liang ◽  
Yong Yang ◽  
Xin-Hua Hou ◽  
Jing-Bo Kong ◽  
...  
Keyword(s):  
Experimental Study ◽  
Pulmonary Embolism ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Acute Pulmonary Embolism ◽  
Hepatocyte Growth

scholarly journals Long Term Stabilization of Expanding Aortic Aneurysms by a Short Course of Cyclosporine A through Transforming Growth Factor-Beta Induction

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28903 ◽  
Author(s):  
Jianping Dai ◽  
Stéphanie Michineau ◽  
Grégory Franck ◽  
Pascal Desgranges ◽  
Jean-Pierre Becquemin ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cyclosporine A ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Aortic Aneurysms ◽  
Short Course ◽  
Growth Factor Beta

The Effects of Cyclosporine on Protein Expression of P53 and Transforming Growth Factor-Beta in Human Renal Tubular Cells

2000 ◽  
Vol 6 (S2) ◽  
pp. 604-605
Author(s):  
H. Song ◽  
C. Wei
Keyword(s):  
Growth Factor ◽  
Cyclosporine A ◽  
Transforming Growth Factor Beta ◽  
Renal Cell ◽  
Transforming Growth Factor ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Cellular Apoptosis ◽  
Growth Factor Beta ◽  
Renal Tubular

Cyclosporine-A (CsA) is the widely used immunosuppressant drug in renal transplantation. However, the effects of cyclosporine-A are limited by a significant nephrotoxicity. The mechanisms of CsA-induced allograft nephropathy are remaining controversial. Recent study indicated that cellular apoptosis may contribute to the cyclosporine A-mediated cytotoxic action. To date, regarding the effects of cyclosporine A on renal cell apoptosis-related gene expression remain poorly defined. p53 is an important gene in control of renal cell growth and death. Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that has anti-proliferative as well as fibrogenic properties.We hypothesized that cyclosporine-A may increase p53 and TGF-β expression in renal tubular cells. These actions of cyclosporine-A may contribute to the cellular apoptosis, fibrosis and CsA-induced nephrotoxicity. Therefore, current study was designed to determine the effects of cyclosporine-A on the p53 and TGF-βl protein expression by immunohistochemical staining (IHCS) in cultured human tubular cells.

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