Role of Selenium and/ or Vitamin E in Preventing Some Pre-and Post-Partum Problems in Dromedary She Camels

Background and Aims: Women who develop GDM (gestational diabetes mellitus) have a relative insulin secretion deficiency, the severity of which may be predictive for later development of diabetes. This study aimed to investigate the role of fasting plasma glucagon in the prediction of later development of diabetes in pregnant women with GDM. Materials and Methods: The study was conducted on 150 pregnant women with GDM after giving informed oral and written consents and being approved by the research ethical committee according to the declaration of Helsinki. The study was conducted in two phases, first phase during pregnancy and the second one was 6 months post-partum, as we measured fasting plasma glucagon before and after delivery together with fasting and 2 hour post-prandial plasma sugar. Results: Our findings suggested that glucagon levels significantly increased after delivery in the majority 14/25 (56%) of GDM women who developed type 2 DM within 6 months after delivery compared to 6/20 (30%) patients with impaired fasting plasma glucose (IFG) and only 22/105 (20%) non DM women, as the median glucagon levels were 80,76, 55, respectively. Also, there was a high statistical difference between fasting plasma glucagon post-delivery among diabetic and non-diabetic women (p ≤ 0.001). These results indicated the useful role of assessing fasting plasma glucagon before and after delivery in patients with GDM to predict the possibility of type 2 DM. Conclusion: There is a relatively high glucagon level in GDM patients, which is a significant pathogenic factor in the incidence of subsequent diabetes in women with a history of GDM. This could be important in the design of follow-up programs for women with previous GDM.

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Role of Vitamin E in Cellular Antioxidant Defense

Current Chemical Biology ◽

10.2174/2212796810903020197 ◽

2009 ◽

Vol 3 (2) ◽

pp. 197-202

Author(s):

Ching Chow

Keyword(s):

Vitamin E ◽

Antioxidant Defense

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Vitamin E for the management of major depressive disorder: possible role of the anti-inflammatory and antioxidant systems

Nutritional Neuroscience ◽

10.1080/1028415x.2020.1853417 ◽

2020 ◽

pp. 1-15

Author(s):

Luana M. Manosso ◽

Anderson Camargo ◽

Alcir L. Dafre ◽

Ana Lúcia S. Rodrigues

Keyword(s):

Major Depressive Disorder ◽

Vitamin E ◽

Depressive Disorder ◽

Antioxidant Systems ◽

Major Depressive ◽

Anti Inflammatory

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Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?

International Journal of Molecular Sciences ◽

10.3390/ijms22126222 ◽

2021 ◽

Vol 22 (12) ◽

pp. 6222

Author(s):

Kacper Szewczyk ◽

Aleksandra Chojnacka ◽

Magdalena Górnicka

Keyword(s):

Vitamin E ◽

Metabolic Disorders ◽

Tissue Concentration ◽

Biological Properties ◽

Biological Role ◽

Future Research ◽

The Past ◽

The Subject ◽

The Relationship

Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature. They are supplied in various amounts in a diet, mainly from vegetable oils, some oilseeds, and nuts. The main forms in the diet are α- and γ-tocopherol, due to the highest content in food products. Nevertheless, α-tocopherol is the main form of vitamin E with the highest tissue concentration. The α- forms of both tocopherols and tocotrienols are considered as the most metabolically active. Currently, research results indicate also a greater antioxidant potential of tocotrienols than tocopherols. Moreover, the biological role of vitamin E metabolites have received increasing interest. The aim of this review is to update the knowledge of tocopherol and tocotrienol bioactivity, with a particular focus on their bioavailability, distribution, and metabolism determinants in humans. Almost one hundred years after the start of research on α-tocopherol, its biological properties are still under investigation. For several decades, researchers’ interest in the biological importance of other forms of vitamin E has also been growing. Some of the functions, for instance the antioxidant functions of α- and γ-tocopherols, have been confirmed in humans, while others, such as the relationship with metabolic disorders, are still under investigation. Some studies, which analyzed the biological role and mechanisms of tocopherols and tocotrienols over the past few years described new and even unexpected cellular and molecular properties that will be the subject of future research.

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The intriguing biological role of vitamin E

Journal of Chemical Education ◽

10.1021/ed060p465 ◽

1983 ◽

Vol 60 (6) ◽

pp. 465 ◽

Cited By ~ 5

Author(s):

S. Krishnamurthy

Keyword(s):

Vitamin E ◽

Biological Role

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