scholarly journals Fungal dermatitis by Scopulariopsis brevicaulisin Guinea pig (Cavia porcellus)

2021 ◽  
Vol 15 (3) ◽  
pp. 184-187
Author(s):  
Guilherme Augusto Marietto Gonçalves ◽  
Alexandre Alberto Tonin
Keyword(s):  
Guinea Pig ◽  
Unusual Case ◽  
Clinical Findings ◽  
Feeding Management ◽  
Combined Use ◽  
Scopulariopsis Brevicaulis ◽  
Fluorescence Test ◽  
Subcutaneous Mycoses ◽  
Hematological Evaluation ◽  
Present Text

Fungal dermatitis is classified into superficial, cutaneous and subcutaneous mycoses. However, the incidence of fungal dermatitis in small mammals is relatively low. Among rodents guinea pig the most affected specie, however it usually has an asymptomatic pattern. The present text reports an unusual case of fungal dermatitis in Caviaporcelluscaused by Scopulariopsis brevicaulis. The animal was received with complaint of alteration of coat around the neck, as well as report of incorrect feeding management. During the physical examination the presence of a dry and crusty dermatitis, negative on fluorescence test of wood. Samples of blood, skin, scabs and hair were collected for parasitic and mycological analysis. The hematological evaluation showed only a discrete eosinophilia; no ectoparasites were observed, but it was noticed the presence of Scopulariopsis brevicaulis. The animal underwent terbinafine and griseofulvin protocol, with total regression of the lesions after 30 days. S. brevicaulis is an unusual geophilic fungus causing animal mycosis, presenting more pathological reports in human mycoses, thus, representing a zoonotic potential. According to the clinical findings and results obtained from mycology assay, it was diagnosed dermatitis by Scopulariopsis brevicaulis, secondary to nutritional deficiency. The combined use of topical terbinafine with systemic griseofulvin was efficient in the treatment. Finally, it was recommended a dietary correction.

Nutritional B12 Deficiency in Infants of Vitamin B12-Deficient Mothers

2011 ◽  
Vol 81 (5) ◽  
pp. 328-334 ◽  
Author(s):  
Oya Halicioglu ◽  
Sezin Asik Akman ◽  
Sumer Sutcuoglu ◽  
Berna Atabay ◽  
Meral Turker ◽  
...  
Keyword(s):  
Megaloblastic Anemia ◽  
Maternal Diet ◽  
Clinical Manifestations ◽  
Serum Vitamin ◽  
Failure To Thrive ◽  
Clinical Findings ◽  
Vitamin B ◽  
Animal Products ◽  
Hematological Evaluation ◽  
Nutritional Vitamin

Aim: Nutritional vitamin B12 deficiency in infants may occur because the maternal diet contains inadequate animal products. Clinical presentations of the infants who had nutritional vitamin B12 deficiency were analyzed in this study. Subjects and Methods: Patients with nutritional vitamin B12 deficiency were enrolled in the study between 2003 and 2010. The diagnosis was based on a nutritional history of mothers and infants, clinical findings, hematological evaluation, and low level of serum vitamin B12. Results: Thirty children aged 1 - 21 months constituted the study group. Poverty was the main cause of inadequate consumption of animal products of the mothers. All infants had predominantly breastfed. The most common symptoms were developmental delay, paleness, apathy, lethargy, anorexia, and failure to thrive. Hematological findings were megaloblastic anemia (83.3 %), thrombocytopenia (30 %), and severe anemia (13.3 %). All of the mothers had low serum B12 levels; eight of them had megaloblastic anemia. Conclusion: The unusual clinical manifestations of vitamin B12 deficiency may also be seen apart from neurological and hematological findings. Nutritional vitamin B12 deficiency due to maternal deficiency might be a serious health problem in infants. Therefore, screening and supplementation of pregnant and lactating women to prevent infantile vitamin B12 deficiency should be considered.

scholarly journals Identification of a novel type 2 fiber population in mammalian skeletal muscle by combined use of histochemical myosin ATPase and anti-myosin monoclonal antibodies.

1990 ◽  
Vol 38 (2) ◽  
pp. 257-265 ◽  
Author(s):  
L Gorza
Keyword(s):  
Monoclonal Antibodies ◽  
Guinea Pig ◽  
Atpase Activity ◽  
High Activity ◽  
Skeletal Muscles ◽  
Enzyme Histochemistry ◽  
Myosin Atpase ◽  
Myosin Atpase Activity ◽  
Combined Use

A novel type of myosin heavy chain (MHC), called 2X, has been recently identified in type 2 fibers of rat skeletal muscles using an immunochemical approach. In the present study, the same panel of anti-MHC monoclonal antibodies was used in immunohistochemistry combined with enzyme histochemistry to identify and compare type 2X fibers in hindlimb skeletal muscles of rat, mouse, and guinea pig. Immunohistochemistry shows that 2X MHC is localized in a large subset of type 2 fibers and is co-expressed with 2A or 2B MHC in a small number of fibers. Enzyme histochemistry shows that type 2X fibers display low myosin ATPase activity after pre-incubation at pH 4.3 and high activity after paraformaldehyde pre-incubation at pH 10.4. After pre-incubation at pH 4.6, myosin ATPase shows intermediate and high activity in rat and mouse 2X fibers, respectively, whereas it is low in guinea pig 2X fibers. Succinate dehydrogenase displays moderate to high activity in 2X fibers of all species. Taken together, these staining patterns allow this novel fiber population to be distinguished from the other type 2 fibers using only enzyme histochemistry. Nevertheless, the combined use of immuno- and enzyme histochemistry prevents incorrect fiber typing due to the interspecies variability of myosin ATPase activity among the correspondent fiber types, and completely modifies the presently used classification of mouse type 2 fibers.

scholarly journals The Philadelphia Chromosome in an Unusual Case of Myeloproliferative Disease

Blood ◽  
1965 ◽  
Vol 26 (4) ◽  
pp. 471-478 ◽  
Author(s):  
CLARK W. HEATH ◽  
WILLIAM C. MOLONEY
Keyword(s):  
Ankylosing Spondylitis ◽  
Direct Relationship ◽  
Unusual Case ◽  
Philadelphia Chromosome ◽  
Myeloproliferative Disorders ◽  
Clinical Findings ◽  
Myeloproliferative Disease ◽  
Diagnostic Significance ◽  
History Of

Abstract In an unusual case of myeloproliferative disease, the Ph1 chromosome was found in association with persistently elevated levels of LAP activity. Clinical findings in this case included marked thrombocytosis, basophilocytosis, absence of splenomegaly and a preceding history of untreated ankylosing spondylitis. Cytogenetic findings were compatible with the existence of the Ph1 chromosome in erythroid and megakaryocytic as well as granulocytic marrow precursors. This case illustrates the difficulties currently encountered in the clinical differentiation of myeloproliferative disorders and in interpreting the diagnostic significance of the Ph1 chromosome. The co-existence in this case of the Ph1 chromosome and elevated LAP does not support the concept of a direct relationship between Group G chromosomes and LAP activity.

scholarly journals Case Report of a Satin Guinea Pig with Fibrous Osteodystrophy That Resembles Human Pseudohypoparathyroidism

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Miguel Gallego
Keyword(s):  
Case Report ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Clinical Findings ◽  
Term Treatment ◽  
Ionized Calcium ◽  
Heterozygous Mutation ◽  
Serum Samples ◽  
Balanced Diet ◽  
Long Term Treatment

A case report of a 2-year-old female satin guinea pig with a history of dental overgrowth and lameness and radiological lesions of fibrous osteodystrophy is presented. The most relevant clinical findings were bone demineralization, high level of parathyroid hormone (PTH), normophosphatemia, normal ionized calcium, and low total thyroxine (tT4) with a normal renal function. Long-term treatment was based on teeth coronal reduction and maintaining a balanced diet. PTH measurement was performed with a kit suitable for rats to test 4 different paired samples of guinea pigs and resulted in similar results for each pair of measurements. Two kits routinely employed in dogs and cats failed in measuring PTH in guinea pig serum samples. The ionized calcium, PTH, and tT4 values, not previously reported in similar cases, were obtained. The determination of tT4 could be useful in the diagnosis of fibrous osteodystrophy in guinea pigs. The observed findings show similarity with human pseudohypoparathyroidism type Ia, a disease caused by an inactivating heterozygous mutation of the stimulatory G proteinαsubunit from the maternal genome that induces multiple hormone resistance and that courses with a syndrome called Albright hereditary osteodystrophy. Naturally occurring pseudohypoparathyroidism in animals has been reported previously only in a ferret.

Effects of combined use of class I antiarrhythmic agents on V max of guinea-pig ventricular muscles

1991 ◽  
Vol 5 (S4) ◽  
pp. 801-804
Author(s):  
Junji Toyama ◽  
Takashi Kawamura ◽  
Itsuo Kodama
Keyword(s):  
Guinea Pig ◽  
Class I ◽  
Antiarrhythmic Agents ◽  
Combined Use

scholarly journals UNILATERAL PROFOUND DEAFNESS – A POSSIBLE MECHANISM

2021 ◽  
Vol 27 (3) ◽  
pp. 3829-3834
Author(s):  
Konstantin Georgiev ◽  
◽  
Yana Pacholova ◽  
◽  
◽  
...  
Keyword(s):  
Hyperbaric Oxygenation ◽  
Combined Treatment ◽  
Hearing Threshold ◽  
Clinical Findings ◽  
Tectorial Membrane ◽  
Unilateral Deafness ◽  
Hearing Function ◽  
Combined Use ◽  
Profound Deafness ◽  
Glycerol Test

Purpose: To explain the clinical findings of patients with profound unilateral deafness who have recovered the hearing function after a combined treatment of hyperbaric oxygenation and dehydrant therapy. Material and method: 11 patients with profound sudden unilateral hearing loss above 90 dB SPL, intolerance to sounds similar to recruitment, at levels 10-20 dB above the hearing threshold (105-120 dB SPL), positive glycerol test and unexpected good recovery of hearing within 1-2 months are described. Results: All patients have perfect outcome results without the use of glucocorticoids. Conclusions: Based on articles about experiments with genetically modified animals and acquired deafness, we propose a possible mechanism of damage explaining the clinical findings and the favorable outcome of the disease – a disconnection between the tectorial membrane and stereocilia. Thus mechano-electrical transducer (MET) of hair cells cannot be activated. The combined use of hyperbaric oxygenation and dehydrant medications can lead to recovery of the hearing function.

Spontaneous Thyroid Haemorrhage: A Cause of Upper Airway Obstruction

2019 ◽  
Vol 18 (4) ◽  
pp. 248-250
Author(s):  
Micheal Wong ◽  
◽  
Yogesvaran Kanapaty ◽  
Yew Toong Liew ◽  
Adzreil Bakri ◽  
...  
Keyword(s):  
Unusual Case ◽  
Clinical Signs ◽  
Upper Airway ◽  
Rare Condition ◽  
Clinical Findings ◽  
Airway Compromise ◽  
Airway Protection ◽  
Anterior Neck ◽  
Life Threatening ◽  
Intravenous Steroids

Background: Spontaneous thyroid haemorrhage is a very rare condition that is potentially life-threatening. We report an unusual case of spontaneous thyroid haemorrhage leading to airway compromise requiring urgent intervention. We highlight key clinical findings and management steps with comparison to similar cases in the literature. Case Summary: An adult male presented with sudden anterior neck swelling and bruises on his neck and chest with hoarseness and dysphagia. Clinical assessment and CT scan revealed a thyroid haemorrhage with laryngopharyngeal, neck and chest haematoma. He was intubated for airway protection and given intravenous steroids and antibiotics. He was extubated well after 3 days. Conclusion: Careful prompt management of the patient’s airway is of vital importance as worsening haematoma can lead to rapid airway compromise. Acute physicians should be aware of the clinical signs of thyroid haemorrhage, as this rare condition may present to the acute medical take.

scholarly journals Filariasis of the Breast in a Pregnant Woman Diagnosed by Fine-needle Aspiration Cytology: A Case Report

1995 ◽  
Vol 3 (6) ◽  
pp. 245-247
Author(s):  
Melanie Lau ◽  
Pamela Tauchi ◽  
Milton Kim ◽  
Francis Liu ◽  
Thomas Namiki
Keyword(s):  
Pregnant Woman ◽  
Fine Needle Aspiration ◽  
Unusual Case ◽  
Wuchereria Bancrofti ◽  
The United States ◽  
Needle Aspiration ◽  
Clinical Findings ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
In Pregnancy

Background:Despite increased immigration to the United States from endemic areas, the diagnosis of microfilariasis in this country remains infrequent. This disease may occasionally present as a breast mass, in the absence of other clinical findings.Case:We report an unusual case ofWuchereria bancroftidiagnosed in a pregnant woman by breast fine-needle aspiration (FNA) and discuss the clinical implications of filariasis in pregnancy.Conclusion:FNA is safe and reliable in pregnancy. Infants of mothers with breast filariasis should be monitored.

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