scholarly journals UNILATERAL PROFOUND DEAFNESS – A POSSIBLE MECHANISM

2021 ◽  
Vol 27 (3) ◽  
pp. 3829-3834
Author(s):  
Konstantin Georgiev ◽  
◽  
Yana Pacholova ◽  
◽  
◽  
...  
Keyword(s):  
Hyperbaric Oxygenation ◽  
Combined Treatment ◽  
Hearing Threshold ◽  
Clinical Findings ◽  
Tectorial Membrane ◽  
Unilateral Deafness ◽  
Hearing Function ◽  
Combined Use ◽  
Profound Deafness ◽  
Glycerol Test

Purpose: To explain the clinical findings of patients with profound unilateral deafness who have recovered the hearing function after a combined treatment of hyperbaric oxygenation and dehydrant therapy. Material and method: 11 patients with profound sudden unilateral hearing loss above 90 dB SPL, intolerance to sounds similar to recruitment, at levels 10-20 dB above the hearing threshold (105-120 dB SPL), positive glycerol test and unexpected good recovery of hearing within 1-2 months are described. Results: All patients have perfect outcome results without the use of glucocorticoids. Conclusions: Based on articles about experiments with genetically modified animals and acquired deafness, we propose a possible mechanism of damage explaining the clinical findings and the favorable outcome of the disease – a disconnection between the tectorial membrane and stereocilia. Thus mechano-electrical transducer (MET) of hair cells cannot be activated. The combined use of hyperbaric oxygenation and dehydrant medications can lead to recovery of the hearing function.

Pengaruh bising lalu lintas terhadap penurunan fungsi pendengaran pada juru parkir di kota Denpasar

2013 ◽  
Vol 40 (2) ◽  
Author(s):  
Ni Ketut Susilawati ◽  
Wayan Sudana ◽  
Eka Putra Setiawan
Keyword(s):  
Hearing Impairment ◽  
Noise Exposure ◽  
Traffic Noise ◽  
Hearing Threshold ◽  
Noise Pollution ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Hearing Function

Background: Noise pollution or noise is an unwanted sound which is disturbing to human beings.However small or soft the sound, if it is undesirable it is considered as noise. Noise induced hearingloss is a sensorineural hearing loss that is commonly encountered second to presbycusis. Purpose: Toknow the effect of traffic noise exposure on hearing impairment to the employees of the Parking DistrictCompany of the Denpasar city and to improve diagnostic detection on hearing impairment caused bynoise. Method: A cross sectional study was conducted at the Parking District Company office. Thepopulations of this study were the employees of the Parking District Company. Samples of this study were the employees who were exposed to traffic noise and control samples were an employee who was unexposed. Samples were selected by simple random sampling. Results: From 40 parking attendants,27 persons (67.5%) aged above 35 years old. The parking attendants who had been working for ten to fifteen years were 36 persons (90%) and no history using ear protection when working. Seven persons(17.5%) had referred DPOAE upon examination with increase hearing threshold on audiogram result.In this study the parking attendants who had hearing deficit induced by noise were 7 persons (17.5%)and only one person (2.5%) in control group. There was a statistically significant effect of traffic noiseto hearing function deficit (p<0.05). Conclusion: Traffic noise has effect in hearing function deficit onthe parking attendants.ORLI Vol. 40 No. 2 Tahun 2010Key words: NIHL, parking attendant, audiometry, DPOAE.

High Blood Glucose Levels Affect Auditory Brainstem Responses after Acoustic Overexposure in Rats

2021 ◽  
pp. 1-8
Author(s):  
Jae-Hun Lee ◽  
Sang Hee Ji ◽  
Jae Yun Jung ◽  
Min Young Lee ◽  
Chi-Kyou Lee
Keyword(s):  
Blood Glucose ◽  
Hearing Threshold ◽  
Auditory Brainstem ◽  
Diabetic Rats ◽  
Control Groups ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Hearing Function ◽  
Brainstem Response

Introduction: Diabetes mellitus (DM) is a systemic disease characterized by hyperglycemia and several pathological changes. DM-related hearing dysfunctions are associated with histological changes. Here, we explore hearing function and synaptic changes in the inner hair cells (IHCs) of rats with streptozotocin (STZ)-induced diabetes. Methods: STZ was injected to trigger diabetes. Rats with DM were exposed to narrow-band noise (105 dB SPL) for 2 h, and hearing function was analyzed 1, 3, 7, and 14 days later. Both the hearing threshold and the peak 1 amplitude of the tone auditory brainstem response were assessed. After the last functional test, animals were sacrificed for histological evaluation. Results: We found no changes in the baseline hearing threshold; however, the peak 1 amplitude at the low frequency (4 kHz) was significantly higher in both DM groups than in the control groups. The hearing threshold had not fully recovered at 14 days after diabetic rats were exposed to noise. The peak 1 amplitude at the higher frequencies (16 and 32 kHz) was significantly larger in both DM groups than in the control groups. The histological analysis revealed that the long-term DM group had significantly more synapses in the 16 kHz region than the other groups. Conclusions: We found that high blood glucose levels increased peak 1 amplitudes without changing the hearing threshold. Diabetic rats were less resilient in threshold changes and were less vulnerable to peak 1 amplitude and synaptic damage than control animals.

scholarly journals Experience of Using Hyperbaric Oxygenation in the Treatment of Radionecrosis That Developed as a Complication of Stereotactic Radiosurgical Treatment of Meningioma on the Example of a Clinical Case

2021 ◽  
Vol 9 (4) ◽  
pp. 670-676
Author(s):  
A. S. Tokarev ◽  
V. N. Stepanov ◽  
V. A. Rak ◽  
O. L. Yevdokimova ◽  
I. A. Terekhin ◽  
...  
Keyword(s):  
Clinical Picture ◽  
Hyperbaric Oxygenation ◽  
Radiation Necrosis ◽  
Late Complication ◽  
Intravenous Contrast ◽  
X Ray ◽  
Combined Use ◽  
Radiation Induced ◽  
Magnetic Resonance Imaging Mri ◽  
And Control

In contrast to conventional microsurgery, stereotactic radiosurgery has an advantage in the treatment of intracranial masses, avoiding severe complications associated with open surgery. In rare cases, the use of the method is associated with the development of radiation-induced injuries, one of which is radiation necrosis (RN). This is a late complication of radiosurgery, developing mainly 6 months after radiation exposure. The neurological manifestations of this complication depend on location, and the clinical picture is very diverse. The method of magnetic resonance imaging (MRI) with intravenous contrast enhancement is quite often the first link in neuroimaging, which helps to suggest the presence of this complication based on the X-ray picture and to clarify the location of changes.We presented the experience of radiation necrosis treatment in a 47-year-old patient who was referred to our department with a diagnosis of frontal meningioma. The patient underwent stereotactic radiosurgical treatment using the Elekta Leksell Gamma Knife Perfextion device, and 6 months later the gradual deterioration began, the patient complained of headache, nausea; central prosoparesis developed. Considering the clinical picture and control MRI data, the changes were interpreted as radionecrosis. In order to control the complication, the patient underwent standard glucocroticosteroid therapy, supplemented by hyperbaric oxygenation (HBO), which made it possible to achieve regression of the adverse clinical and radiological manifestations of the complication. Thus, on a clinical example, it was demonstrated that the combined use of glucocorticosteroids and HBOs is highly effective in the treatment of RN.

THE TREATMENT OF HYPERTHYROIDISM IN CHILDHOOD WITH THIOURACIL DRUGS

PEDIATRICS ◽  
1956 ◽  
Vol 17 (2) ◽  
pp. 221-229
Author(s):  
Judson J. Van Wyk ◽  
Melvin M. Grumbach ◽  
Thomas H. Shepard ◽  
Lawson Wilkins
Keyword(s):  
Combined Treatment ◽  
Substantial Reduction ◽  
Antithyroid Drugs ◽  
Minimal Period ◽  
Continuous Therapy ◽  
The Past ◽  
Prognostic Sign ◽  
Combined Use ◽  
Treat All

During the past 10 years thiouracil and propylthiouracil have been used to treat all children with hyperthyroidism in the Harriet Lane Home Endocrine Clinic. Follow-ups are available on 16 children whose disease began before 13 years of age. Eight of this group are now in a period of prolonged remission; 4 have required subsequent surgery, and 4 are still under treatment. The occurrence of adolescence has not been found to induce a relapse in any child who was previously in remission. Reduction in the size of the goiter while the patient is receiving treatment has been found to be the best prognostic sign. The combined use of thyroid with antithyroid drugs has caused involution of the gland in those patients whose goiters remained large after treatment with propylthiouracil alone. The ultimate value of this combined treatment remains to be determined. It is recommended that surgery be reserved for those children who are sensitive to antithyroid drugs, who fail to co-operate or cannot be followed closely. In the remainder, treatment with antithyroid drugs should be continued until there is substantial reduction in the size of the gland. A period of 2 years of continuous therapy is suggested as the minimal period of treatment.

Antibacterial therapy of infectious eye diseases

2021 ◽  
pp. 38-40
Author(s):  
A. E. Babushkin ◽  
◽  
G. R. Saitova ◽  
E. N. Matyukhina ◽  
◽  
...  
Keyword(s):  
Foreign Bodies ◽  
Contact Lenses ◽  
Combined Treatment ◽  
Anterior Segment ◽  
Clinical Effectiveness ◽  
Eye Diseases ◽  
Eye Drops ◽  
Bacterial Keratitis ◽  
Good Tolerability ◽  
Combined Use

The aim of the work was to study the clinical effectiveness of the combined treatment of keratitis and keratoconjunctivitis of bacterial etiology with the combined use of ocomistin eye drops and oftocipro ointment. These drugs were used in complex therapy in 12 patients in the treatment of this ophthalmopathology, which was caused corneal microtrauma after ingestion of foreign bodies or wearing contact lenses. At the same time, in most cases, microflora in the form of staphylococci was detected. Observations of the effectiveness of such a combined treatment for infectious and bacterial lesions of the eye anterior segment showed good tolerability and high (in 11 patients, in 91.7% of cases) clinical effectiveness of this therapy. Key words: bacterial keratitis and keratoconjunctivitis, treatment, antiseptic-okomistin, antibiotic-ciprofloxacin ointment.

scholarly journals COVID-19-related sudden sensorineural hearing loss

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Nada Khaleel Yaseen ◽  
Raid M. Al-Ani ◽  
Rasheed Ali Rashid
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Clinical Characteristics ◽  
Smoking Habit ◽  
Hearing Threshold ◽  
Treatment Protocol ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Unilateral Deafness ◽  
Nose And Throat

Background: Sudden sensorineural hearing loss (SSNHL) can be a feature of COVID-19. It may present alone or with other symptoms of the disease. However, there is little written in the literature about its occurrence. We aimed to evaluate the socio-clinical characteristics and outcome of confirmed mild- to moderate COVID-19 cases with SSNHL in Tikrit city, Iraq. Materials and Methods: This descriptive study was conducted at the Otolaryngology Department, Tikrit General Hospital, Tikrit city, Iraq. The period of the study was from December 1, 2020 to June 30, 2021.Mild and moderate COVID-19 subjects confirmed by real-time polymerase reaction were included in the study. Detailed demographic (age, gender, and smoking habit) and clinical characteristics (onset and duration of deafness, side, severity, associated ear, nose, and throat symptoms, and comorbidity) were recorded for every patient. Outcomes following the steroid treatment protocol were also registered. Results: SSNHL was identified in 26 patients, of whom 20 (76.9%) were women, 20 (76.9%) were in the age group ≥ 30 years, and 21 (80.8%) were non-smokers. Around three-quarters of the subjects were identified within the first week of deafness occurrence. Bilateral (18/26) was more common than unilateral deafness (8/26); therefore, the total number of deaf ears was 44. Besides, bilateral symmetrical deafness (13/18) outnumbered the asymmetrical type (5/18). Around three-quarters were of moderate severity. The most common otological symptom was tinnitus (25/26). The most common nose and throat symptom was anosmia (6/26). The mean hearing threshold before and after treatment with oral steroids ± intratympanic steroids was 50.91 ± 11.777 dB and 40.24 ± 15.693, respectively. One patient with bilateral SSNHL was lost to follow-up; the remaining number of deaf ears was 42, and half of them were partially improved. The outcome of the treatment showed no statistically significant relation with the duration, side, and severity of SSNHL (p>0.05). Conclusion: The majority of COVID-19-related SSNHL cases presented within one week of onset, with bilateral outnumbering unilateral cases. Tinnitus was the most common associated symptom. Treatment with steroids achieved partial improvement in half of the cases, and this outcome was not affected by the duration, side, and severity of deafness.

scholarly journals The importance of aminoguanidine and methylprednisolone administration in lung contusion after chest trauma

2021 ◽  
Vol 38 (4) ◽  
pp. 504-510
Author(s):  
Fatih ÇALIŞKAN ◽  
Hızır Ufuk AKDEMİR ◽  
Celal KATI ◽  
Latif DURAN ◽  
Tolga GÜVENÇ
Keyword(s):  
Combined Treatment ◽  
Serum Levels ◽  
The Other ◽  
Pulmonary Contusion ◽  
Sprague Dawley ◽  
Treatment Groups ◽  
Sprague Dawley Rats ◽  
Combined Use ◽  
Significant Difference ◽  
All Treatment

This study aims to evaluate the effect of the antioxidant and anti-inflammatory properties of aminoguanidine and metylprednisolone (MP) on lung tissue in a pulmonary contusion model of rats and evaluate whether their combined use improves treatment efficacy. This study included 35 female Sprague Dawley rats weighing 250-300 grams. The rats were divided into five groups as following: Sham; Pulmonary Contusion (PC); PC+MP, PC group treated with i.p methylprednisolone; PC+AG, PC group treated with i.p Aminoguanidine; and PC+AG+MP, PC group treated with Aminoguanidine and methylprednisolone. Each group had seven animals. Blood and lung tissues were studied biochemically and histopathologically. When compared groups according to serum levels of biomarkers, serum YKL-40, nitrate-nitrite, catalase, and TBARS levels were significant different. Serum YKL-40 levels were decreased after treatments in three groups. The serum YKL-40 levels in PC+AG group were lower than the other treatment groups, especially compared to PC + MP (p=0.028). Serum nitrate-nitrite levels were decreased in all treatment groups (PC+MP, PC+AG and PC+MP+AG). The lowest levels were measured in PC+MP+AG; but there was no statistically significant difference compared to PC group (p>0.05). Serum catalase levels were increased in all treatment groups. The higher levels were measured in PC+MP+AG than the other single treatment groups; however, PC+MP+AG and PC+MP were statistically significant different compared to PC group (p=0.001 and p=0.002 respectively). Serum TBARS levels were decreased in all treatment groups compared to Sham group (p<0.001) and PC group (p<0.001). The lowest levels were measured in PC+MP+AG compared to PC group (p<0.001). Histopathologic and immunohistochemical staining scores were decreased at all the treatment groups, especially PC+MP+AG. We suggest the use of combined treatment of methylprednisolone and aminoguanidine for the treatment of pulmonary contusion.

scholarly journals Combination of oridonin and TRAIL induces apoptosis in uveal melanoma cells by upregulating DR5

2021 ◽  
Vol 14 (12) ◽  
pp. 1834-1842
Author(s):  
Xin Hua ◽  
◽  
Guo-Sheng Gao ◽  
Xiao-Lei Ye ◽  
◽  
...  
Keyword(s):  
Cell Cycle ◽  
Western Blot ◽  
Caspase 3 ◽  
Combined Treatment ◽  
Choroidal Melanoma ◽  
Inhibitory Effect ◽  
Expression Levels ◽  
Combined Use ◽  
Apoptosis Protein ◽  
Related Proteins

AIM: To investigate the inhibitory effect of the combined use of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and oridonin on choroidal melanoma cell lines, and to explore its underlying mechanism. METHODS: MUM-2B and C918 cells were treated with different concentrations of TRAIL and oridonin, and MTT assay used to evaluate the inhibition rate of the two compounds on cells. Then, the cell cycle distribution and apoptosis were detected by flow cytometry, and changes in apoptosis-related proteins such as death receptor 5 (DR5), a-caspase-3, and x-linked inhibitor of apoptosis protein (XIAP) were detected by Western blot. MUM-2B cells were transfected with si-DR5, which interfered with the expression of the DR5 gene. MTT and Western blot assay were used to detect cell activity and apoptosis-related proteins. RESULTS: When TRAIL and oridonin were simultaneously administered to the MUM-2B cells, the apoptosis rate was significantly higher than that by the two drugs individually. However, the effect of combined use of TRAIL and oridonin on C918 cells was not significantly different from that used alone. Cell cycle analysis showed that TRAIL and oridonin could induce G2/M arrest in MUM-2B cells. The Western blot results showed that the protein expression levels of the DR5, a-caspase-3, and BAX increased, while the expression levels of the anti-apoptosis-related proteins XIAP and BCL-2 were suppressed when TRAIL and oridonin simultaneously administered to MUM-2B cells. Interfering the expression of DR5 gene in MUM-2B cells could reverse the inhibitory effect of oridonin and TRAIL on the proliferation and apoptosis induction of MUM-2B cells. CONCLUSION: The inhibitory effects of oridonin and TRAIL on MUM-2B cells are significantly enhanced when they were administered as a combined treatment, which may ascribe to up-regulation of DR5.

scholarly journals Technological qualities of common winter wheat (Triticum aestivum L.) grown in conditions of unconventional agriculture

2021 ◽  
Vol 8 (2) ◽  
pp. 74-87
Author(s):  
Veselin Dochev
Keyword(s):  
Winter Wheat ◽  
Combined Treatment ◽  
Wheat Variety ◽  
Triticum Aestivum L ◽  
Wheat Grain ◽  
Combined Use ◽  
Solution Preparation ◽  
Biodynamic Preparations ◽  
Formation Phase ◽  
Made In

Abstract During the period 2019 - 2020, a study was conducted on soil type calcic chernozem with Venka 1 common winter wheat variety. The experiment is based on the block method, in four replications with a size of the experimental plot of 10 m2. Sowing was carried out in October with a sowing rate of 500 sprouts/m2 after the predecessor sugar beet. In the appropriate periods, treatments were made in 4 variants: 1) Control - untreated variant, 2) Treatment with biodynamic preparations: 500 + Fladen preparation + preparation 501, 3) Treatment with biological preparations: Heliosulfur + Free N. 4) Combined treatment with the same biodynamic and biological preparations. Preparation 500 was applied in the phase of autumn and spring wheat tillering - 5% solution. Preparation 501 was applied in the phase ear formation - 1.5 g for 30 l of water/da. Fladen preparation is applied in the phase of autumn and spring tillering - 1.5% solution. Heliosulfur was applied in the ear formation phase - flowering at a dose of 50 ml/da, at an appropriate date on the biodynamic calendar. Free N was applied to the soil in the phase of autumn and spring tillering at a dose of 50 ml/da, at an appropriate date on the biodynamic calendar. The analysis of the technological qualities is made according to the respective ISO methodology. The statistical data processing was performed with the STATGRAPH program. The application of biodynamic and biological preparations and their joint use leads to an increase in the yield of wet gluten, as well as an increase in the content of N, P, K and protein in wheat grain. It has been proven that the combined use of biodynamic and biological preparations increases the content of dry matter, organic matter and the content of nitrogen-free extracts in wheat grain. The content of crude proteins has been shown to increase only in the varieties treated with biodynamic and biological preparations.

Combined Use of PGPR and Reduced Rates of Azoxystrobin to Improve Management of Sheath Blight of Rice

Plant Disease ◽  
2020 ◽  
Author(s):  
Xin-Gen (Shane) Zhou ◽  
K. Vijay Krishna Kumar ◽  
Linda W. Zhou ◽  
M. S. Reddy ◽  
Joseph W. Kloepper
Keyword(s):  
Combined Treatment ◽  
Plant Growth Promoting Rhizobacteria ◽  
Field Studies ◽  
Sheath Blight ◽  
Subtilis Strain ◽  
Boot Stage ◽  
Combined Use ◽  
Full Rate ◽  
Plant Growth Promoting ◽  
Reduced Rate

Farmers heavily rely on the use of strobilurin fungicides to manage sheath blight (ShB) caused by Rhizoctonia solani AG1-IA, the most important disease in rice in the southern United States. Greenhouse and field studies were conducted to evaluate the potential use of plant growth-promoting rhizobacteria (PGPR) in combination with a reduced rate of azoxystrobin as a strategy to improve the current fungicide-reliant management. Of the nine antagonistic PGPR strains screened in the greenhouse, Bacillus subtilis strain MBI600 provided the most significant and consistent suppression of ShB. Efficacy of strain MBI600 was further evaluated at the concentrations of zero, 103, 106, 109, and 1011 CFU/ml alone or in combinations with zero, 17, 33, 50, 67, 83, and 100% of the recommended rate (0.16 kg a.i./ha) of azoxystrobin. Strain MBI600 applied at 106,109, and 1011 CFU/ml alone was effective in reducing ShB severity. Combinations of this strain at these rates with 33% or more of the recommended rate of azoxystrobin further reduced ShB severity. A dose response model defining the relationships between strain MBI600, azoxystrobin, and ShB severity was established. Estimates of the effective concentrations, EC50 and EC90, of strain MBI600 when applied in combination with 50% of the recommended rate of azoxystrobin were 104 and 109 CFU/ml, respectively. A field trial was conducted over 4 years to verify the efficacy of their combinations. Strain MBI600 alone, when applied at 109 CFU/ml at the boot stage, reduced ShB severity but did not significantly increase grain yields each year. Combination of strain MBI600 with azoxystrobin at the half-recommended rate improved efficacy of strain MBI600, reducing ShB severity to a level comparable to that of azoxystrobin applied at the full rate in all four years. The combined treatment also increased grain yield by 14 to 19% comparable to the fungicide applied at the full rate in 3 of 4 years. Combined use of PGPR strain MBI600 with a reduced rate of azoxystrobin can be a viable management option for control of ShB while allowing producers to use less fungicide on rice.

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