The book is the culmination of 50 years of intensive research by the author, who is broadly acknowledged to be the most important pioneer and current research leader who models how brains give rise to minds, notably how neural circuits in multiple brain regions interact together to generate psychological functions. The book provides a unified understanding of how, where, and why our brains can consciously see, hear, feel, and know about the world, and effectively plan and act within it. It hereby embodies a revolutionary Principia of Mind that clarifies how autonomous adaptive intelligence is achieved, thereby providing mechanistic explanations of multiple mental disorders, biological bases of morality, religion, and the human condition, as well as solutions to large-scale problems in machine learning, technology, and Artificial Intelligence. Because brains embody a universal developmental code, unifying insights also emerge about all living cellular tissues and about how mental laws reflect laws of the physical world.