Lipid Nanoparticles and Active Natural Compounds: A Perfect Combination for Pharmaceutical Applications

2019 ◽  
Vol 26 (24) ◽  
pp. 4681-4696 ◽  
Author(s):  
Carmelo Puglia ◽  
Rosario Pignatello ◽  
Virginia Fuochi ◽  
Pio Maria Furneri ◽  
Maria Rosaria Lauro ◽  
...  
Keyword(s):  
Water Solubility ◽  
Chemical Nature ◽  
Natural Compounds ◽  
Lipid Nanoparticles ◽  
Pharmaceutical Applications ◽  
Therapeutic Properties ◽  
Colloidal Carrier ◽  
Carrier Systems ◽  
Active Natural ◽  
Significant Health

Phytochemicals represent an important class of bioactive compounds characterized by significant health benefits. Notwithstanding these important features, their potential therapeutic properties suffer from poor water solubility and membrane permeability limiting their approach to nutraceutical and pharmaceutical applications. Lipid nanoparticles are well known carrier systems endowed with high biodegradation and an extraordinary biocompatible chemical nature, successfully used as platform for advanced delivery of many active compounds, including the oral, topical and systemic routes. This article is aimed at reviewing the last ten years of studies about the application of lipid nanoparticles in active natural compounds reporting examples and advantages of these colloidal carrier systems.

scholarly journals Case studies of enhanced pharmacodynamic activity of poorly oral bioavailable drugs via solid lipid nanoparticles

2021 ◽  
Vol 11 (2) ◽  
pp. 204-208
Author(s):  
D Raju
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Absorption ◽  
Lipid Nanoparticles ◽  
Lymphatic Transport ◽  
Therapeutic Effectiveness ◽  
Therapeutic Activity ◽  
Solid Lipid ◽  
Current Review ◽  
Colloidal Carrier ◽  
Carrier Systems

Solid lipid nanoparticles (SLNs) considered as an alternative vehicle for the enhanced oral absorption of drugs, and also to enhance therapeutic effectiveness after oral administration. Pharmacodynamic activity of drug is mainly describes the pharmacological and therapeutic activity of drug to the biological system. Lipid nanoparticles especially SLNs made of physiological inert lipid molecules and helps the lymphatic transport. Numerous literatures is available on the effect of SLNs and other colloidal carrier systems on the pharmacokinetic activity of poorly bioavailable drugs, to improve their oral absorption and also respective mechanisms for the improved oral bioavailability. However, very few literatures is reported on the pharmacodynamic activity and the effect of dose on the pharmacodynamic activity. Therefore, the current review is mainly dealing with the effect of SLNs on the pharmacodynamic activity discussed.   Keywords: Oral absorption, solid lipid nanoparticles, lymphatic transport, pharmacokinetics, pharmacodynamics.

scholarly journals Applications of Polymeric and Lipid Nanoparticles in Ophthalmic Pharmaceutical Formulations: Present and Future Considerations

2014 ◽  
Vol 17 (3) ◽  
pp. 278 ◽  
Author(s):  
Hugo Almeida ◽  
Maria Helena Amaral ◽  
Paulo Lobão ◽  
Ana C Silva ◽  
José Manuel Sousa Loboa
Keyword(s):  
Targeted Delivery ◽  
Pharmaceutical Formulations ◽  
Lipid Nanoparticles ◽  
Routes Of Administration ◽  
Gelling Properties ◽  
Ophthalmic Administration ◽  
Ocular Drugs ◽  
New Generation ◽  
Colloidal Carrier ◽  
Carrier Systems

The unique properties and characteristics of ocular tissues and the whole set of defence mechanisms of the ocular globe make the instillation of ocular drugs into a difficult task with a low rate of therapeutic response. One of the challenges for the new generation of ophthalmic pharmaceutical formulations is to increase the bioavailability of drugs administered by the ocular route and, therefore, their therapeutic efficacy. This can be achieved with the use of some strategies that provide an increase in the formulation pre-corneal residence time, mucoadhesion and penetration across the eye tissues. Colloidal carrier systems have been very successfully used for the selective and targeted delivery of drugs for several routes of administration. In this context, nanoparticles prepared with specific polymers or lipids and coated, dispersed or suspended in polymer solutions with mucoadhesion properties or in situ gelling properties will be an excellent strategy that deserves attention and further research. In this review, the characteristics and main properties of polymeric and lipid nanoparticles are discussed and examples and advantages of the application of these colloidal carrier systems for the ophthalmic administration of drugs are presented. The future directions of the research required in this specific field are also presented.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

ChemInform Abstract: Solid Lipid Nanoparticles: Colloidal Carrier Systems for Drug Delivery

ChemInform ◽  
2011 ◽  
Vol 43 (2) ◽  
pp. no-no ◽  
Author(s):  
G. Swathi ◽  
N. L. Prasanthi ◽  
S. S. Manikiran ◽  
N. Ramarao
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Colloidal Carrier ◽  
Carrier Systems

Solid lipid nanoparticles of stearic acid for the drug delivery of paliperidone

RSC Advances ◽  
2015 ◽  
Vol 5 (84) ◽  
pp. 68743-68750 ◽  
Author(s):  
Sacheen Kumar ◽  
Jaspreet Kaur Randhawa
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Antipsychotic Drug ◽  
Solid Lipid Nanoparticles ◽  
Water Solubility ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Poor Water Solubility

Paliperidone is an antipsychotic drug having poor water solubility and bioavailability. Solid lipid nanoparticles of stearic acid loaded with paliperidone were prepared to enhance the bioavailability.

scholarly journals Cyclic peptide drugs approved in the last two decades (2001-2021)

2021 ◽  
Author(s):  
Huiya Zhang ◽  
Shiyu Chen
Keyword(s):  
Small Molecules ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Peptide Drugs ◽  
Pharmaceutical Applications ◽  
Therapeutic Properties

In contrast to the major families of small molecules and antibodies, cyclic peptides, as a family of synthesizable macromolecules, have distinct biochemical and therapeutic properties for pharmaceutical applications. Cyclic peptide-based...

Remarkable Advances in the Asymmetric Synthesis of Biologically Active Natural Compounds from the Advent of Chiral Auxiliaries

2020 ◽  
pp. 1-51
Author(s):  
Gaspar Diaz-Muñoz ◽  
Izabel Luzia Miranda ◽  
Suélen Karine Sartori ◽  
Daniele Cristina de Rezende ◽  
Jefferson Viktor Barros de Paula Baeta ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Natural Compounds ◽  
Biologically Active ◽  
Chiral Auxiliaries ◽  
Active Natural

scholarly journals Lipid Nanostructured Particles as Emerging Carriers for Targeted Delivery of Bioactive Molecules: Applications in Food and Biomedical Sciences (An Overview)

2020 ◽  
Vol 77 (1) ◽  
pp. 37
Author(s):  
Patricia MUNTEAN ◽  
Carmen SOCACIU ◽  
Mihai Adrian SOCACIU
Keyword(s):  
Targeted Delivery ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Bioactive Molecules ◽  
Biomedical Sciences ◽  
Nanostructured Particles ◽  
Drug Conjugates ◽  
Carrier Systems

Lipid nanoparticles are getting a growing scientific and technological interest, worldwide. Either Solid Lipid Nanoparticles (SLNs), Nanostructured Lipid Carriers (NLCs), Lipid Drug Conjugates (LDCs) or Polymer-Lipid Nanoparticles (PLNs) have been produced and investigated last years, being reccomended as emerging carrier systems for many food and biomedical applications. An overview of the last publications, mainly since 2017 is presented, underlying the most important methods and techniques used for their preparation (e.g. high shear homogenization in hot and cold conditions, ultrasound assisted melt emulsification) as well techniques applied for measuring the size, calorimetric properties, zeta-potential, etc. Most relevant data related to the use of food-grade ingredients and designed lipid nanoparticles as delivery systems for organic and inorganic bioactive molecules in food or packaging’s are presented. The major reason for this trend in food science is the aim to overcome problems associated with the low bioavailability of many lipophilic bioactive compounds which are claimed to bring benefits to human health (carotenoid or anthocyanin pigments, sterols, vitamins). Finally, the recent applications of different formulas of lipid nanoparticles as drug carriers for in vitro experiments or for in vivo therapy (oral, parenteral or transdermal formulas) are presented.

scholarly journals Novel Neuroprotective Formulations Based on St. John’s Wort Extract

2014 ◽  
Vol 3 (4) ◽  
pp. 3 ◽  
Author(s):  
Monica Vazzana ◽  
Ana S. Macedo ◽  
Antonello Santini ◽  
Caterina Faggio ◽  
Eliana B. Souto
Keyword(s):  
Bioactive Compounds ◽  
Drug Carrier ◽  
Chemical Characterization ◽  
Lipid Nanoparticles ◽  
Special Focus ◽  
St John’S Wort ◽  
St John's Wort ◽  
Wide Range ◽  
Carrier Systems

<p>St. John’s Wort (SJW) has been intensively studied in the last years with respect to its pharmacological properties and to understand the mechanism of action of its bioactive compounds. In fact, it is currently used for the treatment of several disorders. Nevertheless, only recently nanotechnology has been applied for the delivery of SJW extract in vivo, to enhance its neuroprotective properties. In the present review, the advantages, the chemical characterization and the special biological features of SJW extract are discussed, underlining the potential use of nanotechnology in the development of drug carrier systems based on lipid nanoparticles. A special focus is given to solid lipid nanoparticles (SLN) and to nanostructured lipid carriers (NLC) given their versatility for a wide range of bioactive compounds.</p>

scholarly journals Interaction of Solid Lipid Nanoparticles and Specific Proteins of the Corona Studied by Surface Plasmon Resonance

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Mauricio E. Di Ianni ◽  
Germán A. Islan ◽  
Cecilia Y. Chain ◽  
Guillermo R. Castro ◽  
Alan Talevi ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Polyvinyl Alcohol ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Solid Lipid Nanoparticles ◽  
Chemical Nature ◽  
Biological Fluids ◽  
Protein Corona ◽  
Lipid Nanoparticles ◽  
Solid Lipid

The applications of pharmaceutical and medical nanosystems are among the most intensively investigated fields in nanotechnology. A relevant point to be considered in the design and development of nanovehicles intended for medical use is the formation of the “protein corona” around the nanoparticle, that is, a complex biomolecular layer formed when the nanovehicle is exposed to biological fluids. The chemical nature of the protein corona determines the biological identity of the nanoparticle and influences, among others, the recognition of the nanocarrier by the mononuclear phagocytic system and, thus, its clearance from the blood. Recent works suggest that Surface Plasmon Resonance (SPR), extensively employed for the analysis of biomolecular interactions, can shed light on the formation of the protein corona and its interaction with the surroundings. The synthesis and characterization of solid lipid nanoparticles (SLN) coated with polymers of different chemical nature (e.g., polyvinyl alcohol, chitosans) are reported. The proof-of-concept for the use of SPR technique in characterizing protein-nanoparticle interactions of surface-immobilized proteins (immunoglobulin G and bovine serum albumin, both involved in the formation of the corona) subjected to flowing SLN is demonstrated for non-chitosan-coated nanoparticles. All assayed nanosystems show more preference for IgG than for BSA, such preference being more pronounced in the case of polyvinyl-alcohol-coated SLN.

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