Biomorphic Ceramics for Drug Delivery in Bone Tissue Regeneration

2017 ◽  
Vol 23 (24) ◽  
Author(s):  
Patricia Diaz-Rodriguez ◽  
Mariana Landin
Keyword(s):  
Drug Delivery ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Biomorphic Ceramics

scholarly journals Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery

2012 ◽  
Vol 370 (1963) ◽  
pp. 1400-1421 ◽  
Author(s):  
María Vallet-Regí ◽  
Isabel Izquierdo-Barba ◽  
Montserrat Colilla
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Cells ◽  
Added Value ◽  
Bone Tissue Regeneration ◽  
Local Drug Delivery ◽  
Chemical Compositions ◽  
Sustained Drug Release

This review article describes the importance of structure and functionalization in the performance of mesoporous silica bioceramics for bone tissue regeneration and local drug delivery purposes. Herein, we summarize the pivotal features of mesoporous bioactive glasses, also known as ‘templated glasses’ (TGs), which present chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. An in-depth study concerning the possibility of tailoring the structural and textural characteristics of TGs at the nanometric scale and their influence on bioactive behaviour is discussed. The highly ordered mesoporous arrangement of cavities allows these materials to confine drugs to be subsequently released, acting as drug delivery devices. The functionalization of mesoporous silica walls has been revealed as the cornerstone in the performance of these materials as controlled release systems. The synergy between the improved bioactive behaviour and local sustained drug release capability of mesostructured materials makes them suitable to manufacture three-dimensional macroporous scaffolds for bone tissue engineering. Finally, this review tackles the possibility of covalently grafting different osteoinductive agents to the scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.

scholarly journals Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2881
Author(s):  
Vyacheslav Ogay ◽  
Ellina A. Mun ◽  
Gulshakhar Kudaibergen ◽  
Murat Baidarbekov ◽  
Kuat Kassymbek ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Drug Delivery Systems ◽  
Bone Repair ◽  
Surgical Techniques ◽  
Delivery Systems ◽  
Bone Tissue Regeneration ◽  
In Vivo Studies ◽  
Natural And Synthetic

Despite the high regenerative capacity of bone tissue, there are some cases where bone repair is insufficient for a complete functional and structural recovery after damage. Current surgical techniques utilize natural and synthetic bone grafts for bone healing, as well as collagen sponges loaded with drugs. However, there are certain disadvantages associated with these techniques in clinical usage. To improve the therapeutic efficacy of bone tissue regeneration, a number of drug delivery systems based on biodegradable natural and synthetic polymers were developed and examined in in vitro and in vivo studies. Recent studies have demonstrated that biodegradable polymers play a key role in the development of innovative drug delivery systems and tissue engineered constructs, which improve the treatment and regeneration of damaged bone tissue. In this review, we discuss the most recent advances in the field of polymer-based drug delivery systems for the promotion of bone tissue regeneration and the physical-chemical modifications of polymers for controlled and sustained release of one or more drugs. In addition, special attention is given to recent developments on polymer nano- and microparticle-based drug delivery systems for bone regeneration.

Nanomaterials for bone tissue regeneration: updates and future perspectives

Nanomedicine ◽  
2019 ◽  
Vol 14 (22) ◽  
pp. 2987-3006 ◽  
Author(s):  
Michael J Hill ◽  
Baowen Qi ◽  
Rasoul Bayaniahangar ◽  
Vida Araban ◽  
Zahra Bakhtiary ◽  
...  
Keyword(s):  
Biological Sciences ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Multidisciplinary Approach ◽  
Bone Tissue Regeneration ◽  
Future Perspectives ◽  
Made In

Joint replacement and bone reconstructive surgeries are on the rise globally. Current strategies for implants and bone regeneration are associated with poor integration and healing resulting in repeated surgeries. A multidisciplinary approach involving basic biological sciences, tissue engineering, regenerative medicine and clinical research is required to overcome this problem. Considering the nanostructured nature of bone, expertise and resources available through recent advancements in nanobiotechnology enable researchers to design and fabricate devices and drug delivery systems at the nanoscale to be more compatible with the bone tissue environment. The focus of this review is to present the recent progress made in the rationale and design of nanomaterials for tissue engineering and drug delivery relevant to bone regeneration.

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