Local and systemic drug delivery systems for bone tissue regeneration

Despite the high regenerative capacity of bone tissue, there are some cases where bone repair is insufficient for a complete functional and structural recovery after damage. Current surgical techniques utilize natural and synthetic bone grafts for bone healing, as well as collagen sponges loaded with drugs. However, there are certain disadvantages associated with these techniques in clinical usage. To improve the therapeutic efficacy of bone tissue regeneration, a number of drug delivery systems based on biodegradable natural and synthetic polymers were developed and examined in in vitro and in vivo studies. Recent studies have demonstrated that biodegradable polymers play a key role in the development of innovative drug delivery systems and tissue engineered constructs, which improve the treatment and regeneration of damaged bone tissue. In this review, we discuss the most recent advances in the field of polymer-based drug delivery systems for the promotion of bone tissue regeneration and the physical-chemical modifications of polymers for controlled and sustained release of one or more drugs. In addition, special attention is given to recent developments on polymer nano- and microparticle-based drug delivery systems for bone regeneration.

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Advances in local and systemic drug delivery systems for post-surgical cancer treatment

Journal of Materials Chemistry B ◽

10.1039/d0tb00987c ◽

2020 ◽

Vol 8 (37) ◽

pp. 8507-8518

Author(s):

Md Aquib ◽

Ajkia Zaman Juthi ◽

Muhammad Asim Farooq ◽

Manasik Gumah Ali ◽

Alhamzah Hasan Waheed Janabi ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Treatment ◽

Drug Delivery Systems ◽

Graphical Representation ◽

Delivery Systems ◽

Systemic Drug Delivery ◽

Systemic Drug

Graphical representation of local and systemic drug delivery systems.

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Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Gels ◽

10.3390/gels6020014 ◽

2020 ◽

Vol 6 (2) ◽

pp. 14 ◽

Cited By ~ 3

Author(s):

Esfandyar Askari ◽

Amir Seyfoori ◽

Meitham Amereh ◽

Sadaf Samimi Gharaie ◽

Hanieh Sadat Ghazali ◽

...

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Drug Delivery Systems ◽

Drug Loading ◽

High Capacity ◽

Delivery Systems ◽

Stimuli Responsive ◽

Post Surgery ◽

Systemic Drug Delivery ◽

Systemic Drug

Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted.

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Topical and Systemic Drug Delivery Systems for Targeted Therapy

Peripheral Receptor Targets for Analgesia ◽

10.1002/9780470522226.ch19 ◽

2009 ◽

pp. 473-514

Author(s):

Urs O. Hfeli ◽

Amit Kale

Keyword(s):

Drug Delivery ◽

Targeted Therapy ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Systemic Drug Delivery ◽

Systemic Drug

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Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

Nanomaterials ◽

10.3390/nano12010047 ◽

2021 ◽

Vol 12 (1) ◽

pp. 47

Author(s):

Xiao Ma ◽

Yun Gao ◽

Duoyi Zhao ◽

Weilin Zhang ◽

Wei Zhao ◽

...

Keyword(s):

Drug Delivery ◽

Bacterial Infections ◽

Drug Delivery Systems ◽

Molecular Mechanisms ◽

Drug Loading ◽

Delivery Systems ◽

Titanium Implants ◽

Local Drug Delivery ◽

Systemic Drug Delivery ◽

Systemic Drug

Titanium implants have always been regarded as one of the gold standard treatments for orthopedic applications, but they still face challenges such as pain, bacterial infections, insufficient osseointegration, immune rejection, and difficulty in personalizing treatment in the clinic. These challenges may lead to the patients having to undergo a painful second operation, along with increased economic burden, but the use of drugs is actively solving these problems. The use of systemic drug delivery systems through oral, intravenous, and intramuscular injection of various drugs with different pharmacological properties has effectively reduced the levels of inflammation, lowered the risk of endophytic bacterial infection, and regulated the progress of bone tumor cells, processing and regulating the balance of bone metabolism around the titanium implants. However, due to the limitations of systemic drug delivery systems—such as pharmacokinetics, and the characteristics of bone tissue in the event of different forms of trauma or disease—sometimes the expected effect cannot be achieved. Meanwhile, titanium implants loaded with drugs for local administration have gradually attracted the attention of many researchers. This article reviews the latest developments in local drug delivery systems in recent years, detailing how various types of drugs cooperate with titanium implants to enhance antibacterial, antitumor, and osseointegration effects. Additionally, we summarize the improved technology of titanium implants for drug loading and the control of drug release, along with molecular mechanisms of bone regeneration and vascularization. Finally, we lay out some future prospects in this field.

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Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery

Philosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences ◽

10.1098/rsta.2011.0258 ◽

2012 ◽

Vol 370 (1963) ◽

pp. 1400-1421 ◽

Cited By ~ 120

Author(s):

María Vallet-Regí ◽

Isabel Izquierdo-Barba ◽

Montserrat Colilla

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Bone Tissue ◽

Tissue Regeneration ◽

Bone Cells ◽

Added Value ◽

Bone Tissue Regeneration ◽

Local Drug Delivery ◽

Chemical Compositions ◽

Sustained Drug Release

This review article describes the importance of structure and functionalization in the performance of mesoporous silica bioceramics for bone tissue regeneration and local drug delivery purposes. Herein, we summarize the pivotal features of mesoporous bioactive glasses, also known as ‘templated glasses’ (TGs), which present chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. An in-depth study concerning the possibility of tailoring the structural and textural characteristics of TGs at the nanometric scale and their influence on bioactive behaviour is discussed. The highly ordered mesoporous arrangement of cavities allows these materials to confine drugs to be subsequently released, acting as drug delivery devices. The functionalization of mesoporous silica walls has been revealed as the cornerstone in the performance of these materials as controlled release systems. The synergy between the improved bioactive behaviour and local sustained drug release capability of mesostructured materials makes them suitable to manufacture three-dimensional macroporous scaffolds for bone tissue engineering. Finally, this review tackles the possibility of covalently grafting different osteoinductive agents to the scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.

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MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEMS CONTAINING POLYSACCHARIDES

Cellulose Chemistry and Technology ◽

10.35812/cellulosechemtechnol.2020.54.86 ◽

2020 ◽

Vol 54 (9-10) ◽

pp. 889-902

Author(s):

IRINA M. PELIN ◽

DANA M. SUFLET

Keyword(s):

Drug Delivery ◽

Drug Administration ◽

Drug Delivery Systems ◽

Enzymatic Degradation ◽

Low Cost ◽

Hepatic Metabolism ◽

Drug Action ◽

Delivery Systems ◽

Buccal Drug Delivery ◽

Systemic Drug

The buccal mucosa is an attractive site for drug administration as it allows avoiding the enzymatic degradation of the drug in the gastrointestinal tract and its hepatic metabolism. For buccal administration, different drug delivery systems with controlled mucoadhesion have been developed and some of them are available on the market. Mucoadhesion makes it possible to obtain prolonged, local or systemic drug action, and this process is highly influenced by several factors, among which, the reactivity of macromolecules from the formulations is very important. Polysaccharides are increasingly studied due to their abundance in natural resources, low-cost availability and easy chemical modification, but also due to their biocompatibility, biodegradability and non-toxicity properties. This review briefly describes the advantages of using the buccal route of drug administration, the influencing factors that are taken into account for obtaining mucoadhesive dosage forms, and the main polysaccharides and their derivatives used for fabrication of buccal drug delivery systems.

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The Application of Energetic SHS Reactions in the Synthesis of Multi-functional Bone Tissue Engineering and Drug Delivery Systems

MRS Proceedings ◽

10.1557/proc-0896-h01-07 ◽

2005 ◽

Vol 896 ◽

Author(s):

Reed Ayers ◽

Doug Burkes ◽

Guglielmo Gottoli ◽

H.C. Yi ◽

Jaque Guigné ◽

...

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Calcium Phosphate ◽

Bone Tissue Engineering ◽

Combustion Synthesis ◽

Bone Tissue ◽

Drug Delivery Systems ◽

Exothermic Reaction ◽

Functional Materials ◽

Delivery Systems

AbstractThe term combustion synthesis, or self-propagating high temperature synthesis (SHS), refers to an exothermic chemical reaction process that utilizes the heat generated by the exothermic reaction to ignite and sustain a propagating combustion wave through the reactants to produce the desired product(s). The products of combustion synthesis normally are extremely porous: typically 50 percent of theoretical densityAdvantages of combustion synthesis over traditional processing routes, e.g., sintering, in the production of advanced materials such as ceramics, intermetallic compounds and composites include process economics, simplicity of operation, and low energy requirements. However, the high exothermicity and rapid combustion propagation rates necessitate a high degree of control of these reactions.One research area being conducted in the Institute for Space Resources (ISR) at the Colorado School of Mines (CSM) is the application of combustion synthesis (SHS) to synthesize advanced, engineered porous multiphase/heterogeneous calcium phosphate (HCaP), NiTi, NiTi-TiC, TiB-Ti, TiC-Ti for bone tissue engineering and drug delivery systems. Such material systems require a complex combination of properties that can be truly classified as multi-functional materials. The range of properties includes: an overall porosity of 40-60% with a pore size of 200-500 μm; mechanical properties (compression strength and Young’s modulus) that match those of natural bone to avoid ‘stress shielding’; and a surface chemistry that is capable of facilitating bone growth and mineralization.The paper will discuss the synthesis of porous multiphase/heterogeneous calcium phosphate (HCaP), NiTi, NiTi-TiC, TiB-Ti, TiC-Ti for bone tissue engineering and drug delivery systems.

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