Biodegradable mesoporous bioactive glass nanospheres for drug delivery and bone tissue regeneration

2016 ◽  
Vol 27 (22) ◽  
pp. 225102 ◽  
Author(s):  
Xiaojian Wang ◽  
Wei Li
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Mesoporous Bioactive Glass

Preparation of an rhBMP-2 loaded mesoporous bioactive glass/calcium phosphate cement porous composite scaffold for rapid bone tissue regeneration

2015 ◽  
Vol 3 (43) ◽  
pp. 8558-8566 ◽  
Author(s):  
Nan Li ◽  
Chuan Jiang ◽  
Xingdi Zhang ◽  
Xinfeng Gu ◽  
Jingwei Zhang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bioactive Glass ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Phosphate Cement ◽  
Composite Scaffold ◽  
Early Stage ◽  
Bone Tissue Regeneration ◽  
Porous Composite ◽  
Mesoporous Bioactive Glass

An rhBMP-2/MBG/CPC scaffold is beneficial for rapid bone tissue regeneration in the early stage.

scholarly journals Design and Evaluation of Europium Containing Mesoporous Bioactive Glass Nanospheres: Doxorubicin Release Kinetics and Inhibitory Effect on Osteosarcoma MG 63 Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 961 ◽  
Author(s):  
Ying Zhang ◽  
Meng Hu ◽  
Xiang Wang ◽  
Zhufa Zhou ◽  
Yu Liu
Keyword(s):  
Bioactive Glass ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Release Kinetics ◽  
Sol Gel ◽  
Inhibitory Effect ◽  
Vital Role ◽  
Bone Tissue Regeneration ◽  
Doxorubicin Release ◽  
Mesoporous Bioactive Glass

Functional ions and drug factors play a vital role in stimulating bone tissue regeneration as we understand it. In this work, europium-containing mesoporous bioactive glass nanospheres (Eu/MBGs), composed of 60% SiO2—(36–x)%CaO—x%Eu2O3—4%P2O5 (x = 0, 0.5, 1, 2 mol%), were prepared by a facile sol-gel process. The results indicate that Eu ions play an important role to influence the microstructure of MBGs, in which a suitable concentration of Eu (1 mol%) increases their surface area (502 m2/g) as well as their pore volume (0.34 cm3/g). Proper doping of Eu ions in MBGs can observably induce apatite mineralization and improve the doxorubicin (DOX) release behavior. Furthermore, DOX-loaded Eu/MBGs could maintain a long-term inhibitory effect on the viability of osteosarcoma MG 63 cells. This work has demonstrated that it is possible to develop functional Eu/MBGs by combining excellent apatite-mineralization ability, controllable drug (DOX) release and antitumor functions for the therapy of bone tissue regeneration.

scholarly journals Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xingdi Zhang ◽  
Deliang Zeng ◽  
Nan Li ◽  
Jin Wen ◽  
Xinquan Jiang ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Mesoporous Bioactive Glass

scholarly journals Bioactıve Glass‐Polymer Nanocomposites for Bone Tıssue Regeneration Applicatıons: A Revıew

2019 ◽  
Vol 21 (8) ◽  
pp. 1900287 ◽  
Author(s):  
Melek Erol‐Taygun ◽  
Irem Unalan ◽  
Maizlinda Izwana Binti Idris ◽  
João F. Mano ◽  
Aldo R. Boccaccini
Keyword(s):  
Bioactive Glass ◽  
Bone Tissue ◽  
Polymer Nanocomposites ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration

scholarly journals Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery

2012 ◽  
Vol 370 (1963) ◽  
pp. 1400-1421 ◽  
Author(s):  
María Vallet-Regí ◽  
Isabel Izquierdo-Barba ◽  
Montserrat Colilla
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Cells ◽  
Added Value ◽  
Bone Tissue Regeneration ◽  
Local Drug Delivery ◽  
Chemical Compositions ◽  
Sustained Drug Release

This review article describes the importance of structure and functionalization in the performance of mesoporous silica bioceramics for bone tissue regeneration and local drug delivery purposes. Herein, we summarize the pivotal features of mesoporous bioactive glasses, also known as ‘templated glasses’ (TGs), which present chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. An in-depth study concerning the possibility of tailoring the structural and textural characteristics of TGs at the nanometric scale and their influence on bioactive behaviour is discussed. The highly ordered mesoporous arrangement of cavities allows these materials to confine drugs to be subsequently released, acting as drug delivery devices. The functionalization of mesoporous silica walls has been revealed as the cornerstone in the performance of these materials as controlled release systems. The synergy between the improved bioactive behaviour and local sustained drug release capability of mesostructured materials makes them suitable to manufacture three-dimensional macroporous scaffolds for bone tissue engineering. Finally, this review tackles the possibility of covalently grafting different osteoinductive agents to the scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.

A highly bioactive and biodegradable poly(glycerol sebacate)–silica glass hybrid elastomer with tailored mechanical properties for bone tissue regeneration

2015 ◽  
Vol 3 (16) ◽  
pp. 3222-3233 ◽  
Author(s):  
Xin Zhao ◽  
Yaobin Wu ◽  
Yuzhang Du ◽  
Xiaofeng Chen ◽  
Bo Lei ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bioactive Glass ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Silica Glass ◽  
Bone Tissue Regeneration ◽  
Biodegradable Poly

A highly bioactive and biodegradable PGS–Silica bioactive glass hybrid elastomer with tailored mechanical properties was developed for bone tissue regeneration application.

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