Aquaporin 4 in Astrocytes is a Target for Therapy in Alzheimer's Disease

Metabolic waste clearance is essential to maintain body homeostasis, in which the lymphatic system plays a vital role. Conversely, in recent years, studies have identified the glial–lymphatic system in the brain, which primarily comprises the inflow of fluid along the para-arterial space. Aquaporin-4 mediates the convection of interstitial fluid in the brain and outflow along the paravenous space. β-Amyloid deposition is a characteristic pathological change in Alzheimer’s disease, and some studies have found that the glial–lymphatic system plays an important role in its clearance. Thus, the glial–lymphatic system may influence Alzheimer’s disease severity and outcome; therefore, this review summarizes the current and available research on the glial–lymphatic system and Alzheimer’s disease.

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Aquaporin-4 polymorphisms predict amyloid burden and clinical outcome in the Alzheimer's disease spectrum

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2020.06.007 ◽

2021 ◽

Vol 97 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Avinash Chandra ◽

Chloe Farrell ◽

Heather Wilson ◽

George Dervenoulas ◽

Edoardo Rosario De Natale ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Outcome ◽

Aquaporin 4 ◽

Amyloid Burden ◽

Disease Spectrum

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The Potential Roles of Aquaporin 4 in Alzheimer’s Disease

Molecular Neurobiology ◽

10.1007/s12035-015-9446-1 ◽

2015 ◽

Vol 53 (8) ◽

pp. 5300-5309 ◽

Cited By ~ 14

Author(s):

Yu-Long Lan ◽

Jie Zhao ◽

Tonghui Ma ◽

Shao Li

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Aquaporin 4

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The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer’s Disease

Neural Plasticity ◽

10.1155/2016/4626593 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 11

Author(s):

Yu-Long Lan ◽

Shuang Zou ◽

Jian-Jiao Chen ◽

Jie Zhao ◽

Shao Li

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Neurodegenerative Disorder ◽

Neuroprotective Effect ◽

Ion Homeostasis ◽

Water Channel ◽

Glutamate Transporter ◽

Aquaporin 4 ◽

Normal Brain ◽

Glutamate Transporter 1

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by memory loss and cognitive dysfunction. Aquaporin-4 (AQP4), which is primarily expressed in astrocytes, is the major water channel expressed in the central nervous system (CNS). This protein plays an important role in water and ion homeostasis in the normal brain and in various brain pathological conditions. Emerging evidence suggests that AQP4 deficiency impairs learning and memory and that this may be related to the expression of glutamate transporter-1 (GLT-1). Moreover, the colocalization of AQP4 and GLT-1 has long been studied in brain tissue; however, far less is known about the potential influence that the AQP4/GLT-1 complex may have on AD. Research on the functional interaction of AQP4 and GLT-1 has been demonstrated to be of great significance in the study of AD. Here, we review the interaction of AQP4 and GLT-1 in astrocytes, which might play a pivotal role in the regulation of distinct cellular responses that involve neuroprotection against AD. The association of AQP4 and GLT-1 could greatly supplement previous research regarding neuroprotection against AD.

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