Amino Acids, Peptides and Peptide Mimetics: A Way to Diseases Prevention and Treatment

2020 ◽  
Vol 24 (21) ◽  
pp. 2391-2392
Author(s):  
Javier Eduardo García Castañeda
Keyword(s):  
Amino Acids ◽  
Peptide Mimetics ◽  
Prevention And Treatment

scholarly journals CALCIUM SALTS OF AMINO ACIDS FOR THE TREATMENT OF OSTEOPOROSIS IN ANIMALS

2018 ◽  
Vol 54 (3) ◽  
pp. 314-318
Author(s):  
D. V. Lopatik ◽  
U. D. Kovalenko ◽  
Z. I. Kuvaeva ◽  
E. A. Manchik
Keyword(s):  
Amino Acids ◽  
Calcium Carbonate ◽  
Bone Tissue ◽  
Therapeutic Effect ◽  
Test Substance ◽  
Calcium Salts ◽  
Treatment Of Osteoporosis ◽  
Prevention And Treatment ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Results of the study of the drug from calcium salts of amino acids (calcium diglycinate, calcium di-L-prolinate) on the model of osteoporosis in animals are described. The test substance was found to have better therapeutic effect in the regeneration of bone tissue in comparison with the drug containing calcium carbonate. The drug containing calcium salts of glycine and L-proline can be used for prevention and treatment of osteoporosis.

METABOLISM OF AMINO ACIDS

PEDIATRICS ◽  
1958 ◽  
Vol 21 (1) ◽  
pp. 117-142
Author(s):  
Selma E. Snyderman
Keyword(s):  
Amino Acids ◽  
Quantitative Difference ◽  
Widespread Application ◽  
Amount Of Information ◽  
Disease States ◽  
Prevention And Treatment ◽  
Pathologic State

There has not as yet been widespread application of the large amount of information which has been accumulating in the field of metabolism of amino acids. There are several ways in which this information could be utilized. Both the prevention and treatment of kwashiorkor might be efficiently accomplished by the supplementation of existing diets with the specific amino acids in which they are deficient. A study of the requirements and of the patterns of excretion of amino acids in various disease states might demonstrate either a qualitative or quantitative difference in requirements of amino acids produced by the pathologic state. Lastly, it is quite possible that a study of metabolism of amino acids in as yet unexplained syndromes might reveal hitherto unrecognized metabolic aberrations.

Novel Peptide Mimetics Based on N-protected Amino Acids Derived from Isomannide as Potential Inhibitors of NS3 Serine Protease of Hepatitis C Virus

2012 ◽  
Vol 9 (4) ◽  
pp. 239-249 ◽  
Author(s):  
Thalita G. Barros ◽  
Bruna C. Zorzanelli ◽  
Sergio Pinheiro ◽  
Monique A. de Brito ◽  
Amilcar Tanuri ◽  
...  
Keyword(s):  
Amino Acids ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Serine Protease ◽  
Peptide Mimetics ◽  
Potential Inhibitors

Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics

Tetrahedron ◽  
1997 ◽  
Vol 53 (38) ◽  
pp. 12789-12854 ◽  
Author(s):  
Stephen Hanessian ◽  
Grant McNaughton-Smith ◽  
Henry-Georges Lombart ◽  
William D. Lubell
Keyword(s):  
Amino Acids ◽  
Peptide Mimetics ◽  
Conformationally Constrained ◽  
Design And Synthesis ◽  
Conformationally Constrained Amino Acids ◽  
Constrained Amino Acids

scholarly journals Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein

Viruses ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 13 ◽  
Author(s):  
Chunyu Wei ◽  
Caishang Zheng ◽  
Jianhong Sun ◽  
Dan Luo ◽  
Yan Tang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Interaction Mechanism ◽  
Foot And Mouth Disease ◽  
Human Enterovirus ◽  
Future Research ◽  
Terminal Domain ◽  
Enterovirus A71 ◽  
Prevention And Treatment ◽  
Infected Cells ◽  
Key Residues

Enterovirus A71 (EVA71) is a human enterovirus belonging to the Picornaviridae family and mostly causes hand-foot-and-mouth disease in infants. Viperin is an important interferon-stimulated gene with a broad antiviral activity against various viruses. However, the effect of viperin on human enteroviruses and the interaction mechanism between EVA71 and viperin remains elusive. Here, we confirmed the EVA71-induced expression of viperin in a mouse model and cell lines and showed that viperin upregulation by EVA71 infection occurred on both the mRNA and protein level. Viperin knockdown and overexpression in EVA71-infected cells indicated that this protein can markedly inhibit EVA71 infection. Interestingly, immunofluorescent confocal microscopy and co-immunoprecipitation assays indicated that viperin interacts and colocalizes with the EVA71 protein 2C in the endoplasmic reticulum. Furthermore, amino acids 50–60 in the N-terminal domain of viperin were the key residues responsible for viperin interaction with 2C. More importantly, the N-terminal domain of viperin was found responsible for inhibiting EVA71 replication. Our findings can potentially aid future research on the prevention and treatment of nervous system damage caused by EVA71 and may provide a potential target for antiviral therapy.

scholarly journals α-Amino Acids as Synthons in the Ugi-5-Centers-4-Components Reaction: Chemistry and Applications

Symmetry ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 798 ◽  
Author(s):  
Sveva Pelliccia ◽  
Ilenia Antonella Alfano ◽  
Ubaldina Galli ◽  
Ettore Novellino ◽  
Mariateresa Giustiniano ◽  
...  
Keyword(s):  
Amino Acids ◽  
Carboxylic Acids ◽  
Functional Groups ◽  
Single Step ◽  
Organic Reactions ◽  
Peptide Mimetics ◽  
Atom Economy ◽  
Organic Transformations ◽  
Huge Variety ◽  
Gain Access

Since the first reports, the Ugi four-component reaction (U-4CR) has been recognized as a keystone transformation enabling the synthesis of peptide mimetics in a single step and with high atom economy. In recent decades, the U-4CR has been a source of inspiration for many chemists fascinated by the possibility of identifying new efficient organic reactions by simply changing one of the components or by coupling in tandem the multicomponent process with a huge variety of organic transformations. Herein we review the synthetic potentialities, the boundaries, and the applications of the U-4CR involving α-amino acids, where the presence of two functional groups—the amino and the carboxylic acids—allowed a 5-center 4-component Ugi-like reaction, a powerful tool to gain access to drug-like multi-functionalized scaffolds.

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