In Silico ADMET Evaluation of Natural DPP-IV Inhibitors for Rational Drug Design against Diabetes

2020 ◽  
Vol 21 (10) ◽  
pp. 768-777
Author(s):  
Rajeev K. Singla ◽  
Bairong Shen
Keyword(s):  
Diabetes Mellitus ◽  
In Silico ◽  
Rational Drug Design ◽  
Diabetic Patients ◽  
Dpp Iv ◽  
Rational Drug ◽  
In Silico Admet ◽  
Pharmacokinetic Properties ◽  
Treatment Of Diabetes ◽  
The Many

Background: As a metabolic and lifestyle disorder, diabetes mellitus poses a prodigious health risk. Out of the many key targets, DPP-IV is one of the very imperative therapeutic targets for the treatment of diabetic patients. Methods: In our current study, we have done the in silico simulations of ADME-T properties for naturally originated potent DPP-IV inhibitors like quinovic acid, stigmasterol, quinovic acid-3-beta-D-glycopyranoside, zygophyloside E, and lupeol. Structural topographies associated with different pharmacokinetic properties have been systematically assessed. Results: Glycosylation on quinovic acid is found to be noteworthy for the improvement of pharmacokinetic and toxicological properties, which leads to the prediction that zygophyloside E can be further tailored down to get the lead DPP-IV inhibitor. Conclusion: This assessment provides useful insight into the future development of novel drugs for the treatment of diabetes mellitus.

scholarly journals Effectiveness of Coriander Seed Extract in decreasing Blood Glucose level among Diabetic Patients

2020 ◽  
Vol 11 (3) ◽  
pp. 2879-2883
Author(s):  
Sheela R ◽  
Merlin Shiny Sheeba ◽  
Poornima ◽  
Priya
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Low Income ◽  
Seed Extract ◽  
Medical Expenditure ◽  
Diabetic Patients ◽  
Treatment Of Diabetes ◽  
Coriander Seed

Diabetes Mellitus (DM) belongs to a group of metabolic disorders. It is characterised by Chronic Hyperglycemia and disturbance of carbohydrate, lipid and protein metabolism. The cause for this condition arises from a disease in insulin secretion. The International Diabetes Federation (IDF) expresses that worldwide 415 million individuals have Diabetes Mellitus. It also predicts that by 2040 this will ascend to 642 billion. The other prediction is that 77% of individuals with Diabetes live in middle and low-income countries. 12% of the worldwide population spend on the treatment of Diabetes. With the escalating medical expenditure in treating Diabetes, a person from middle or low income may find it challenging to meet the expenses. It is an expected tendency for an individual from this category to opt for a more straightforward treatment that suits their pocket. In the recent past, all over the world, people from all walks of life know essential things about natural remedies. A lot of researches are going on in support of using natural products per se. One such study is this – on the Effectiveness of Coriander Seed Extract in decreasing Blood Glucose level among Diabetic Patients.Coriandrum Sativum is a plant that has been utilised in the administration of Diabetes. It is a herbaceous plant originally from the Mediterranean and Middle Eastern locales, having a place in the family Apiaceae. It is known to have antifungal, antibacterial, free radical searching, and lipid peroxidation activities. The study was conducted to assess the level of pretest and posttest blood glucose level. And, also to evaluate the effect of coriander seed extract in the treatment of Diabetes Mellitus. An experimental study was chosen to assess the effectiveness of coriander seed extract among diabetic clients. The present study was conducted at Mappedu. 60 male and female who come under inclusion criteria were selected by purposive sampling technique. Data was collected by using a socio-demographic variable, and random blood glucose was assessed by CBG machine. The results revealed that coriander seed extract has a significant effect on decreasing blood glucose level among diabetic patients.

scholarly journals Evaluation of Pharmacokinetic Properties, Toxicity, and Bioactive Cytotoxic Activity of Black Rice (Oryza sativa L.) as Candidates for Diabetes Mellitus Drugs by in silico

2021 ◽  
Vol 11 (4) ◽  
pp. 12301-12311
Keyword(s):  
Diabetes Mellitus ◽  
Oryza Sativa ◽  
Cytotoxic Activity ◽  
In Silico ◽  
Oryza Sativa L ◽  
Test Results ◽  
Black Rice ◽  
Drug Candidates ◽  
Pharmacokinetic Properties ◽  
Β Carotene

The in silico method is widely used to search for drug candidates, namely by predicting physicochemical properties, pharmacokinetics (ADME), toxicity, know the description of drug interactions with target proteins, Rerank Score (RS), and then carried out the Molecular Docking (MD) process. This study intends to predict the physicochemical, pharmacokinetics (ADME) properties, toxicity, and cytotoxic activity of 15 bioactive compounds in black rice (Oryza sativa L.) drug candidates for diabetes mellitus using the GLP-1 target protein. The In silico test results showed that campesterol ferulate, cycloartenol ferulate, lutein, β-carotene, and zeaxanthin found in black rice have physicochemical, pharmacokinetic (ADME), toxicity, and better Rerank Score (RS) properties than omarigliptin (drug). Black rice can also be safely recommended to be consumed by people with diabetes mellitus.

Antimalarial Drug Discovery: In Silico Structural Biology and Rational Drug Design

2009 ◽  
Vol 9 (3) ◽  
pp. 304-318 ◽  
Author(s):  
TAP de Beer ◽  
GA Wells ◽  
PB Burger ◽  
F. Joubert ◽  
E. Marechal ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Structural Biology ◽  
Antimalarial Drug ◽  
In Silico ◽  
Rational Drug Design ◽  
Rational Drug

scholarly journals The Efficacy of Optimism: Benefit Finding in the Treatment of Diabetes in Iranian Patients

ISRN Nursing ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Hossein Karimi Moonaghi ◽  
Hossein Namdar Areshtanab ◽  
Leila Jouybari
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Disease ◽  
Middle Eastern ◽  
Benefit Finding ◽  
The World ◽  
Treatment Of Diabetes ◽  
Lack Of Exercise ◽  
The Many ◽  
Iranian Patients

The incidence of diabetes mellitus is on the rise around the world. Middle Eastern countries will be facing a vast increase in the number of diabetes mellitus cases by 2030. Diagnosis of a chronic disease such as diabetes mellitus can be a shocking and life-altering event. Conversely, a diagnosis of a chronic illness can also offer the patient opportunities to change unhealthy behaviors such as poor diet, smoking, and lack of exercise, making them healthier than before their diagnosis. This is referred to as “benefit finding”. This study reveals the many benefit findings of Iranian patients who have been diagnosed with diabetes mellitus and illustrates how benefit finding can be an integral part of long-term patient care.

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