The Immune System Regulation in Sepsis: From Innate to Adaptive

Sepsis, which is a highly heterogeneous syndrome, can result in death as a consequence of a systemic inflammatory response syndrome. The activation and regulation of the immune system play a key role in the initiation, development and prognosis of sepsis. Due to the different periods of sepsis when the objects investigated were incorporated, clinical trials often exhibit negative or even contrary results. Thus, in this review we aim to sort out the current knowledge in how immune cells play a role during sepsis.

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SYSTEMIC INFLAMMATORY RESPONSE SYNDROME: THE CURRENT STATUS

Journal of Universal College of Medical Sciences ◽

10.3126/jucms.v6i1.21732 ◽

2018 ◽

Vol 6 (1) ◽

pp. 56-61

Author(s):

Manisha Shrestha ◽

Anand Kumar

Keyword(s):

Critical Care ◽

Intensive Care ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Diagnostic Criteria ◽

Current Knowledge ◽

Laboratory Diagnosis ◽

Systemic Inflammatory Response ◽

Current Status ◽

American Society

Systemic inflammatory response syndrome (SIRS) is a frequent and serious problem faced by clinicians in day to day practice and is a major factor of intensive care morbidity and mortality. The American College of Chest Physicians and the American Society of Critical Care Medicine in 1991 published definitions and criteria for systemic inflammatory response syndrome. Since then many researches have been undertaken to better understand the pathophysiology of systemic inflammatory response syndrome and to determine the accuracy of its diagnostic criteria. The criteria set by the 1991 consensus is still popularly used today. However, with the current knowledge on this matter many researchers have put forward the need of refinement in the criteria of systemic inflammatory response syndrome defined by 1991 consensus. This article aims to review the epidemiology, etiology, pathophysiology, laboratory diagnosis, treatment and the current views regarding SIRS.Journal of Universal College of Medical SciencesVol. 6, No. 1, 2018, Page: 56-61

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Global transcriptional profiling of CD15+ granulocytes from patients with septic shock and systemic inflammatory response syndrome (SIRS).

10.31219/osf.io/tuqnd ◽

2019 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Septic Shock ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Microarray Data ◽

Immune Cells ◽

Transcriptional Profiling ◽

The United States ◽

Systemic Inflammatory Response ◽

Data Set ◽

Transcriptional Changes

Sepsis, the body’s reaction to infection in what is normally a sterile bloodstream, is a major cause of mortality in the United States (1). I used a microarray data set from a cohort of thirty-one patients with septic shock or systemic inflammatory response syndrome (2) to determine the major transcriptional changes associated with each disease state. I found that globally, the granulocytes of patients with SIRS resembled that of patients with septic shock at the level of transcription. For many genes expressed in the granulocyte, SIRS represented an “intermediate” gene expression state between that of control patients and those of patients with septic shock. The identification of the most differentially expressed genes in the granulocytic immune cells of patients with septic shock can facilitate the development of novel therapeutics or diagnostics for a condition that, despite decades of research, possesses a 14.7% to 29.9% in-hospital mortality rate (1).

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How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome

Annals of Intensive Care ◽

10.1186/2110-5820-2-27 ◽

2012 ◽

Vol 2 (1) ◽

pp. 27 ◽

Cited By ~ 43

Author(s):

Jérôme Pugin

Keyword(s):

Immune System ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Tissue Injury ◽

Systemic Inflammatory Response

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Immunopathological mechanisms in sepsis of viral etiology in COVID-19

Siberian medical review ◽

10.20333/25000136-2021-6-35-43 ◽

2021 ◽

Vol 6 ◽

pp. 35-43

Author(s):

A.M. Ziganshin ◽

◽

A.R. Mulykov ◽

Keyword(s):

Immune Response ◽

Immune System ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Systemic Inflammatory Response ◽

Membrane Receptors ◽

Human Tissues ◽

Host Organism ◽

Viral Etiology ◽

Coronavirus Infection

The article provides information on immunopathology in sepsis and the commonality between immunopathogenetic processes of sepsis and the new coronavirus infection (COVID-19). As a result of the inability of the immune system to cope with aggression of the pathogen, inadequate immune activity occurs manifested by the systemic inflammatory response syndrome, resulting in damage to tissues of the host organism. In response, compensatory antiinflammatory response syndrome is activated, which is manifested by inhibition of the immune response. One of its main mechanisms is signals produced by membrane receptors and their ligands. Against the background of inability of the host organism to neutralise the pathogen, numerous pathological phenomena and complications occur leading to damage to human tissues.

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