Metallothioneins and Synthetic Metal Chelators as Potential Therapeutic Agents for Removal of Aberrant Metal Ions from Metal-Aβ Species

2014 ◽  
Vol 14 (3) ◽  
pp. 271-281 ◽  
Author(s):  
Ning Xia ◽  
Lin Liu
Keyword(s):  
Metal Ions ◽  
Therapeutic Agents ◽  
Metal Chelators ◽  
Synthetic Metal

scholarly journals Pharmacological activity of metal binding agents that alter copper bioavailability

2015 ◽  
Vol 44 (19) ◽  
pp. 8760-8770 ◽  
Author(s):  
Marian E. Helsel ◽  
Katherine J. Franz
Keyword(s):  
Neurodegenerative Diseases ◽  
Metal Ions ◽  
Pharmacological Activity ◽  
Metal Binding ◽  
Therapeutic Benefit ◽  
Cellular Damage ◽  
Binding Agents ◽  
Synthetic Metal ◽  
Copper Bioavailability

An exploration of synthetic metal-binding agents that alter the bioavailability of copper in ways that may provide therapeutic benefit against neurodegenerative diseases, cancer, infection, and other diseases where misappropriated metal ions are suspected of exacerbating cellular damage.

scholarly journals Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents

Metallomics ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 696-712 ◽  
Author(s):  
Brech Aikman ◽  
Andreia de Almeida ◽  
Samuel M. Meier-Menches ◽  
Angela Casini
Keyword(s):  
Hydrogen Peroxide ◽  
Metal Ions ◽  
Water Flow ◽  
Bioinorganic Chemistry ◽  
Therapeutic Agents ◽  
Cancer Development ◽  
Cellular Transport ◽  
Chemical Probes ◽  
Aquaporin Channels

Metal ions and complexes can interfere with the transcellular water flow but also with the cellular transport of glycerol and hydrogen peroxide,viainhibition of the ubiquitous aquaporin channels.

Synthetic Metal Chelators Which Replace the Natural Growth-Factor Requirements of Arthrobacter terregens

1965 ◽  
Vol 89 (6) ◽  
pp. 1630-1630 ◽  
Author(s):  
Norman E. Morrison ◽  
Alan D. Antoine ◽  
Euline E. Dewbrey
Keyword(s):  
Growth Factor ◽  
Natural Growth ◽  
Metal Chelators ◽  
Synthetic Metal

Reactivities of cyclam derivatives with metal–amyloid-β

2020 ◽  
Vol 7 (21) ◽  
pp. 4222-4238
Author(s):  
Gunhee Kim ◽  
Evan Lelong ◽  
Juhye Kang ◽  
Jong-Min Suh ◽  
Nathalie Le Bris ◽  
...  
Keyword(s):  
Metal Ions ◽  
Amyloid Β ◽  
Metal Chelators

New examples of azamacrocyclic metal chelators that modulate the interactions between metal ions and Aβ and the reactivities of metal–Aβ were developed under criteria based on structural and functional variations on the backbone of Cyclam.

Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug

Metallomics ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1460-1475 ◽  
Author(s):  
Karam Chand ◽  
Rajeshwari Rajeshwari ◽  
Emanuel Candeias ◽  
Sandra M. Cardoso ◽  
Sílvia Chaves ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metal Ions ◽  
Amyloid Β ◽  
Drug Repurposing ◽  
Active Species ◽  
Acetylcholine Esterase ◽  
Metal Chelators ◽  
Redox Active

Two in one drug: repurposing 2 existing drugs into polypharmacological compounds for targeting and regulating multiple pathological factors, including acetylcholine esterase (AChE), metal ions (Mn+) as well as metal associated amyloid-β (Aβ) aggregates and redox active species (ROS), found in Alzheimer's disease (AD).

scholarly journals CAN UVB VARIATIONS RECONCILE SIMULATED QUASAR ABSORPTION LINES AT HIGH REDSHIFT?

2020 ◽  
Vol 56 (1) ◽  
pp. 97-107
Author(s):  
L. A. Garcı́a ◽  
E. V. Ryan-Weber
Keyword(s):  
Metal Ions ◽  
High Redshift ◽  
Statistical Properties ◽  
Absorption Lines ◽  
Quasar Absorption Lines ◽  
Synthetic Metal ◽  
Absorption Features

In this work we present new calculations of the observables associated with synthetic metal and HI absorption lines in the spectra of high redshift quasars, in-spired by questions and limitations raised in work with a uniform Haardt-Madau 2012 ultraviolet background (UVB). We introduce variations at z ≈ 6 to the UVB and HI self–shielding and explore the sensitivity of the absorption features to modifications of the hardness of the UVB. We find that observed SiIV and low ionization states (e.g. CII, SiII, OI) are well represented by a soft UV ionizing field at z = 6, but this same prescription, fails to reproduce the statistical properties of the observed CIV ion absorber population. We conclude that small variations in the UVB (not greater than a dex below Haardt-Madau 2012 emissivity at 1 Ryd) and HI SSh at z ≈ 6 play a major role in improving the estimation of metal ions and HI statistics at high z.

Sign in / Sign up

Export Citation Format

Share Document