Dietary Intake of Hydrolyzable Tannins and Condensed Tannins to Regulate Lipid Metabolism

2021 ◽  
Vol 22 ◽  
Author(s):  
Yuanyang Li ◽  
Leiqi Zhu ◽  
Chong Guo ◽  
Mengzhen Xue ◽  
Fangqi Xia ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Blood Lipid ◽  
Short Chain Fatty Acids ◽  
Lipid Metabolism Disorder ◽  
Alcoholic Fatty Liver ◽  
Metabolism Disorder ◽  
Lower Blood ◽  
Regulate Lipid Metabolism ◽  
Dietary Tannins ◽  
Blood Lipid Levels

Abstract: Lipid metabolism disorder is a multifactor issue, which contributes to several serious health consequences, such as obesity, hyperlipidemia, atherosclerosis diabetes, non-alcoholic fatty liver etc. Tannins, applied as natural derived plant, are commonly used in the study of lipid metabolism disease with excellent safety and effectiveness, while producing less toxic and side effects. Meanwhile, recognition of the significance of dietary tannins in lipid metabolism disease prevention has increased. As suggested by existing evidence, dietary tannins can reduce lipid accumulation, block adipocyte differentiation, enhance antioxidant capacity, increase the content of short-chain fatty acids, and lower blood lipid levels, thus alleviating lipid metabolism disorder. This study is purposed to sum up and analyze plenty of documents on tannins, so as to provide the information required to assess the lipid metabolism of tannins.

scholarly journals Improvement of Hyperlipidemia by Aerobic Exercise in Mice through a Regulatory Effect of miR-21a-5p on its Target Genes

2021 ◽  
Author(s):  
Jinfeng Zhao ◽  
Yaxin Wang ◽  
Anping Chen ◽  
Yu Zeng ◽  
Feng Yan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Aerobic Exercise ◽  
Target Genes ◽  
Exercise Intervention ◽  
Lipid Level ◽  
Liver Steatosis ◽  
Blood Lipid ◽  
Blood Lipid Level ◽  
Lipid Metabolism Disorder ◽  
Metabolism Disorder

Abstract Background and aims Hyperlipidemia is a risk factor for cardiovascular disease, and miR-21a-5p plays an important role in the occurrence and progression of hyperlipidemia, this study aimed to investigate the mechanism of aerobic exercise improved hyperlipidemia through enhancement miR-21a-5p expression.Method Spectrophotometer detected blood lipid level; HE stained liver tissue to check the grade of liver steatosis; QPCR and Western blot detected mRNA expression and protein levels. Results There had a notable improvement in the weight gain, blood lipid level and liver steatosis in hyperlipidemia mice after 8 weeks aerobic exercise intervention. In addition, aerobic exercise significantly up-regulated the expression of miR-21a-5p, and provoked favorable changes in the expression of target genes. Knockdown of miR-21a-5p resulted in dysregulation of lipid metabolism and increased expression of target genes FABP7, HMGCR, ACAT1 and OLR1. While aerobic exercise could alleviate miR-21a-5p knock-down induced lipid metabolism disorder. Conclusion Aerobic exercise improved hyperlipidemia through miR-21a-5p-induced inhibition of target genes FABP7, HMGCR, ACAT1 and OLR1.

scholarly journals Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jinfeng Zhao ◽  
Yicun Song ◽  
Yu Zeng ◽  
Longchang Chen ◽  
Feng Yan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Aerobic Exercise ◽  
Target Genes ◽  
Exercise Intervention ◽  
Lipid Level ◽  
Liver Steatosis ◽  
Blood Lipid ◽  
High Cholesterol Diet ◽  
Lipid Metabolism Disorder ◽  
Metabolism Disorder

AbstractHyperlipidemia is a risk factor for cardiovascular disease, and miR-21a-5p plays an important role in the occurrence and progression of hyperlipidemia. Here, we aimed to investigate the mechanism of aerobic exercise improved hyperlipidemia through enhancing miR-21a-5p expression. In this study, high-fat/high-cholesterol diet mice received 8 weeks of aerobic exercise intervention, then we collected plasma and liver samples, we found that there had a notable improvement in weight gain, blood lipid level, and liver steatosis in hyperlipidemia mice after 8 weeks of aerobic exercise intervention. Besides, aerobic exercise significantly up-regulated the expression of miR-21a-5p and provoked favorable changes in the expression of target genes. Knockdown of miR-21a-5p resulted in dysregulation of lipid metabolism and increased expression of FABP7, HMGCR, ACAT1, and OLR1. While aerobic exercise could alleviate miR-21a-5p knock-down induced lipid metabolism disorder. Taken together, these results demonstrated that aerobic exercise improved hyperlipidemia through miR-21a-5p-induced inhibition of target genes FABP7, HMGCR, ACAT1, and OLR1.

Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 monoclonal antibodies

2021 ◽  
Vol 28 ◽  
Author(s):  
Adel Hajj Ali ◽  
Nour Younis ◽  
Rola Abdallah ◽  
Farah Shaer ◽  
Ali Dakroub ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Lipid Metabolism ◽  
Plasma Cholesterol ◽  
Therapeutic Interventions ◽  
Lipid Lowering ◽  
Lipid Metabolism Disorder ◽  
Metabolism Disorder ◽  
Peripheral Arterial Diseases ◽  
Branching Points ◽  
Genetic Interventions

: Cardiovascular disease (CVD) remains the primary cause of global morbidity and mortality. CVD includes various life-threatening conditions such as myocardial infarction, stroke and peripheral arterial diseases. In this context, atherosclerosis continues to play the principal role in the pathogenesis of these conditions. Atherosclerosis emanates from a set of modifiable and non-modifiable risk factors that include age, male gender, family history, obesity, smoking, diabetes mellitus and hypertension. Recent evidence classifies atherosclerosis as a latent disease affecting all-sized arteries with a predilection for arterial branching points of decreased or absent blood supply. Atherosclerosis is not only a lipid metabolism disorder, but is also a chronic inflammatory one. In this review, we provide a synoptic discussion of the underlying pathological mechanisms of atherosclerosis along with the currently applied therapeutic interventions. We then discuss the classical lipid-lowering therapies as well as the newly discovered therapies. For the classical therapies, we point out the importance of statins and ezetimibe in reducing plasma cholesterol levels by virtue of their effects on synthesis, reuptake and intestinal absorption of cholesterol. We also discuss the role of fibrates in modulating lipid metabolism and improving the ratio of high-density to low-density density lipoproteins. We then focus on the more recent molecular and genetic interventions exemplified by proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies, evinacumab, and microRNA inhibitors. Special attention is also given to clinical trials involving these therapies.

scholarly journals Engineering rice based medium for production of lovastatin with Monascus species

2009 ◽  
Vol 27 (No. 5) ◽  
pp. 352-360 ◽  
Author(s):  
B.P. Panda ◽  
S. Javed ◽  
M. Ali
Keyword(s):  
Blood Lipid ◽  
Red Yeast Rice ◽  
Red Rice ◽  
Box Behnken Design ◽  
Glutinous Rice ◽  
Lower Blood ◽  
Red Mold Rice ◽  
Burman Design ◽  
Plackett Burman Design ◽  
Blood Lipid Levels

Angkak (red mold rice, red yeast rice, Chinese red rice), a traditional Chinese functional food is produced by solid-state fermentation of cooked non-glutinous rice with <i>Monascus</i> species. The secondary metabolite of <i>Monascus</i> species, monacolin K (lovastatin), has been proved to lower blood lipid levels. In this study, the best <i>Monascus purpureus</i> strain was selected from MTCC 369, 410, 1090 based on lovastatin concentration. Four medium parameters (NH<sub>4</sub>Cl, MgSO<sub>4</sub>, NaCl, CaCl<sub>2</sub>) screened by Plackett-Burman design from total nine medium variables were optimised by Box-Behnken design of response surface methodology. Maximum lovastatin production of 3.420 mg/g was predicted in the solid medium containing 20 g rice and 40 ml liquid nutrient (NH<sub>4</sub>Cl 14.32 g/l, MgSO<sub>4</sub> 0.76 g/l, NaCl 14.65 g/l, and CaCl<sub>2</sub> 0.54 g/l) by the point prediction tool of Design Expert Ver. 7.1 software at 14<sup>th</sup> day of fermentation.

Chlorpyrifos exposure induces lipid metabolism disorder at the physiological and transcriptomic levels in larval zebrafish

2019 ◽  
Vol 51 (9) ◽  
pp. 890-899
Author(s):  
Xiaoyu Wang ◽  
Jiajie Zhou ◽  
Manlu Shen ◽  
Jiayan Shen ◽  
Xinyue Zhang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Acid Synthesis ◽  
Treated Group ◽  
Heart Tissue ◽  
Lipid Metabolism Disorder ◽  
Larval Zebrafish ◽  
Metabolism Disorder ◽  
Glucose And Lipid Metabolism ◽  
Lipid Metabolism Disorders ◽  
Cellular Apoptosis

Abstract Chlorpyrifos (CPF) is a widely used insecticide in pest control, and it can affect aquatic animals by contaminating the water. In this study, larval zebrafish were exposed to CPF at concentrations of 30, 100 and 300 μg/l for 7 days. In the CPF-treated group, lipid droplet accumulation was reduced in larval zebrafish. The levels of triglyceride (TG), total cholesterol (TC), and pyruvate were also decreased after CPF exposure. Cellular apoptosis were significantly increased in the heart tissue after CPF exposure compared with the control. Transcription changes in cardiovascular genes were also observed. Through transcriptome analysis, we found that the transcription of 465 genes changed significantly, with 398 upregulated and 67 downregulated in the CPF-treated group, indicating that CPF exposure altered the transcription of genes. Among these altered genes, a number of genes were closely related to the glucose and lipid metabolism pathways. Furthermore, we also confirmed that the transcription of genes related to fatty acid synthesis, TC synthesis, and lipogenesis were significantly decreased in larval zebrafish after exposure to CPF. These results indicated that CPF exposure induced lipid metabolism disorders associated with cardiovascular toxicity in larval zebrafish.

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