Short-term Effect of Fresh Pomegranate Juice on Serum Cortisol and Thyroxine in Patients with type 2 Diabetes

2020 ◽  
Vol 20 (5) ◽  
pp. 355-360
Author(s):  
Saleem Ali Banihani ◽  
Seham M. Makahleh ◽  
Zeyad J. El-Akawi
Keyword(s):  
Type 2 Diabetes ◽  
Serum Cortisol ◽  
Serum Glucose ◽  
Term Effect ◽  
Pomegranate Juice ◽  
Cortisol Response ◽  
Fasting Serum ◽  
Short Term ◽  
Short Term Effect

Background: The effect of pomegranate juice on type 2 diabetic conditions has been determined in various occasions. However, such an effect on cortisol and thyroxine hormones, which are major controllers of energy metabolism, is not yet revealed. Objectives: this study, we intended to measure the short-term effect of fresh pomegranate juice on serum cortisol and thyroxine in patients with type 2 diabetes. Materials and Methods: This study was a randomized clinical trial in which 89 fasted patients with type 2 diabetes were supplemented with fresh pomegranate juice at a dose of 1.5 mL kg-1. Blood specimens were then collected before and at 1 and 3 hours after juice administration. Serum cortisol and thyroxine were assessed using commercial chemiluminescent-immunoassay kits. Results: Serum cortisol, but not thyroxine, was significantly (P < 0.0001) lower in patients with type 2 diabetes after ingesting fresh pomegranate juice. In addition, no significant correlation (r2 = 0.00003, P = 0.9569) was observed between cortisol response to fresh pomegranate juice and the level of fasting serum glucose in the recruited patients. Moreover, no significant difference (P = 0.9118) in cortisol response to fresh pomegranate juice was found between recruited males and females. Conclusions: In conclusion, fresh pomegranate juice decreased serum cortisol, 1 hour after juice ingestion, but not serum thyroxine 3 hours after juice ingestion, in patients with type 2 diabetes. In addition, cortisol response to fresh pomegranate juice was found not to be affected by patients’ gender and the level of fasting serum glucose.

The Short-Term Effect of a Switch from Glybenclamide to Metformin on Blood Pressure and Microalbuminuria in Patients with Type 2 Diabetes Mellitus

2000 ◽  
Vol 31 (6) ◽  
pp. 571-575 ◽  
Author(s):  
Norma Amador-Licona ◽  
Juan-Manuel Guı́zar-Mendoza ◽  
Enrique Vargas ◽  
Guillermo Sánchez-Camargo ◽  
Lilia Zamora-Mata
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Term Effect ◽  
Short Term ◽  
Short Term Effect

Short-Term Effect of Twice-Daily Dosage of Repaglinide in Elderly Patients with Type 2 Diabetes

2015 ◽  
Vol 2 ◽  
pp. 53-57
Author(s):  
Daisuke Takarabe ◽  
Tetsuro Tsujimoto ◽  
Miyako Kishimoto ◽  
Mitsuhiko Noda
Keyword(s):  
Type 2 Diabetes ◽  
Elderly Patients ◽  
Term Effect ◽  
Short Term ◽  
Short Term Effect

scholarly journals Fresh Pomegranate Juice Decreases Fasting Serum Erythropoietin in Patients with Type 2 Diabetes

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Saleem A. Banihani ◽  
Shuaibu M. Shuaibu ◽  
Belal A. Al-Husein ◽  
Seham S. Makahleh
Keyword(s):  
Type 2 Diabetes ◽  
Serum Glucose ◽  
Pomegranate Juice ◽  
Healthy Individuals ◽  
Fasting Serum ◽  
Fasting Serum Glucose ◽  
Chemiluminescent Immunoassay ◽  
And Gender ◽  
Serum Erythropoietin

Pomegranate juice (PJ) has been recognized to have various biological benefits in several pathological conditions. One such benefit is the augmentation of hemoglobin level and the number of erythrocytes in the human body. Here, we assessed the short-term effect of fresh PJ on the level of Erythropoietin (EPO) in patients with type 2 diabetes (T2D) compared to healthy individuals. Blood samples from 59 participants with T2D and 30 healthy individuals were collected after a 12-hour fast and 3 hours after administration of fresh PJ at 1.5 mL per kg body weight. Serum glucose was measured by standard method and commercially available chemiluminescent immunoassay kits were used to determine serum EPO concentration. Mean changes in serum EPO levels 3 hours after ingesting PJ and before the juice ingestion (EPO response to PJ) for both diabetic and healthy participants were -2.002 ± 0.541 vs. - 0.041 ± 0.214, respectively (P = 0.0087). This EPO response to PJ was found not to be correlated with age (P = 0.6622) and gender (P = 0.5354) for patients with T2D, while a negative correlation (P = 0.0183) between EPO response to PJ and fasting serum glucose concentrations was observed in these patients. In conclusion, fresh PJ reduced serum EPO level in patients with T2D, but not in healthy individuals, 3 hours after ingesting the juice. The EPO response to PJ was found to be negatively correlated with fasting serum glucose, but not with age and gender, of patients with T2D. This trial is registered with ClinicalTrials.gov Identifier. NCT03902288.

scholarly journals The impact of circuit resistance training on serum glucose, insulin resistance and health related physical fitness in elderly men with type 2 diabetes

2020 ◽  
Vol 12 (3) ◽  
pp. 61-70
Author(s):  
HAMID ARAZI ◽  
ROGHAYEH GHOLIZADEH ◽  
AMIN SOHBATZADEH ◽  
EHSAN EGHBALI
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Resistance Training ◽  
Training Group ◽  
Serum Glucose ◽  
Fasting Serum ◽  
Elderly Men ◽  
Health Related ◽  
The Impact

Background: Obesity and decreased physical activity are the most important factors in the development of type 2 diabetes, which in recent decades has led to an increase in the number of people with this disease. The aim of this study was to investigate the impact of circuit resistance training (CRT) on serum glucose, insulin resistance and health related physical fitness in elderly men with type 2 diabetes. Material and methods: Twenty-two patients with type 2 diabetes (60.99 ±2.93 years) volunteered to participate in this study. They were divided randomly into two groups: training (n = 11) and control (n = 11). Participants in the training group performed a progressive CRT program for ten weeks. In addition, anthropometry variables, muscular strength and endurance were evaluated before and after ten weeks’ CRT. Also, 10 ml of the blood sample was taken from participants to measure fasting serum glucose, fasting serum insulin and insulin resistance. Results: After ten weeks of CRT, the body composition and glucose dropped significantly (P < 0.05) in the training group. Also, muscular endurance, upper and lower body strength in the post-test were significantly higher than the pre-test in the training group (P < 0.05). Conclusions: CRT led to a significant improvement in insulin resistance, fasting serum glucose, BMI, endurance and strength of elderly men with type 2 diabetes. Therefore, this type of resistance training can be useful for improvement in physical and physiological variables of elderly men with type 2 diabetes.

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