scholarly journals Fresh Pomegranate Juice Decreases Fasting Serum Erythropoietin in Patients with Type 2 Diabetes

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Saleem A. Banihani ◽  
Shuaibu M. Shuaibu ◽  
Belal A. Al-Husein ◽  
Seham S. Makahleh
Keyword(s):  
Type 2 Diabetes ◽  
Serum Glucose ◽  
Pomegranate Juice ◽  
Healthy Individuals ◽  
Fasting Serum ◽  
Fasting Serum Glucose ◽  
Chemiluminescent Immunoassay ◽  
And Gender ◽  
Serum Erythropoietin

Pomegranate juice (PJ) has been recognized to have various biological benefits in several pathological conditions. One such benefit is the augmentation of hemoglobin level and the number of erythrocytes in the human body. Here, we assessed the short-term effect of fresh PJ on the level of Erythropoietin (EPO) in patients with type 2 diabetes (T2D) compared to healthy individuals. Blood samples from 59 participants with T2D and 30 healthy individuals were collected after a 12-hour fast and 3 hours after administration of fresh PJ at 1.5 mL per kg body weight. Serum glucose was measured by standard method and commercially available chemiluminescent immunoassay kits were used to determine serum EPO concentration. Mean changes in serum EPO levels 3 hours after ingesting PJ and before the juice ingestion (EPO response to PJ) for both diabetic and healthy participants were -2.002 ± 0.541 vs. - 0.041 ± 0.214, respectively (P = 0.0087). This EPO response to PJ was found not to be correlated with age (P = 0.6622) and gender (P = 0.5354) for patients with T2D, while a negative correlation (P = 0.0183) between EPO response to PJ and fasting serum glucose concentrations was observed in these patients. In conclusion, fresh PJ reduced serum EPO level in patients with T2D, but not in healthy individuals, 3 hours after ingesting the juice. The EPO response to PJ was found to be negatively correlated with fasting serum glucose, but not with age and gender, of patients with T2D. This trial is registered with ClinicalTrials.gov Identifier. NCT03902288.

Short-term Effect of Fresh Pomegranate Juice on Serum Cortisol and Thyroxine in Patients with type 2 Diabetes

2020 ◽  
Vol 20 (5) ◽  
pp. 355-360
Author(s):  
Saleem Ali Banihani ◽  
Seham M. Makahleh ◽  
Zeyad J. El-Akawi
Keyword(s):  
Type 2 Diabetes ◽  
Serum Cortisol ◽  
Serum Glucose ◽  
Term Effect ◽  
Pomegranate Juice ◽  
Cortisol Response ◽  
Fasting Serum ◽  
Short Term ◽  
Short Term Effect

Background: The effect of pomegranate juice on type 2 diabetic conditions has been determined in various occasions. However, such an effect on cortisol and thyroxine hormones, which are major controllers of energy metabolism, is not yet revealed. Objectives: this study, we intended to measure the short-term effect of fresh pomegranate juice on serum cortisol and thyroxine in patients with type 2 diabetes. Materials and Methods: This study was a randomized clinical trial in which 89 fasted patients with type 2 diabetes were supplemented with fresh pomegranate juice at a dose of 1.5 mL kg-1. Blood specimens were then collected before and at 1 and 3 hours after juice administration. Serum cortisol and thyroxine were assessed using commercial chemiluminescent-immunoassay kits. Results: Serum cortisol, but not thyroxine, was significantly (P < 0.0001) lower in patients with type 2 diabetes after ingesting fresh pomegranate juice. In addition, no significant correlation (r2 = 0.00003, P = 0.9569) was observed between cortisol response to fresh pomegranate juice and the level of fasting serum glucose in the recruited patients. Moreover, no significant difference (P = 0.9118) in cortisol response to fresh pomegranate juice was found between recruited males and females. Conclusions: In conclusion, fresh pomegranate juice decreased serum cortisol, 1 hour after juice ingestion, but not serum thyroxine 3 hours after juice ingestion, in patients with type 2 diabetes. In addition, cortisol response to fresh pomegranate juice was found not to be affected by patients’ gender and the level of fasting serum glucose.

scholarly journals Effect of fresh pomegranate juice on the level of melatonin, insulin, and fasting serum glucose in healthy individuals and people with impaired fasting glucose

2019 ◽  
Vol 8 (1) ◽  
pp. 567-574 ◽  
Author(s):  
Saleem A. Banihani ◽  
Reham A. Fashtaky ◽  
Seham M. Makahleh ◽  
Zeyad J. El‐Akawi ◽  
Omar F. Khabour ◽  
...  
Keyword(s):  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Serum Glucose ◽  
Pomegranate Juice ◽  
Healthy Individuals ◽  
Fasting Serum ◽  
Fasting Serum Glucose

5879Coronary microvascular dysfunction is associated with poor glycemic control in women with diabetes presenting with chest pain and non-obstructive coronary artery disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J D Sara ◽  
R Taher ◽  
N Kolluri ◽  
A Vella ◽  
L O Lerman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Chest Pain ◽  
Glycemic Control ◽  
Obstructive Coronary Artery Disease ◽  
Serum Glucose ◽  
Microvascular Function ◽  
Fasting Serum ◽  
Fasting Serum Glucose

Abstract Background Patients with type 2 diabetes are at an increased risk of cardiovascular events compared to individuals without diabetes. The role glycemic control plays in reducing cardiovascular risk remains uncertain. Coronary microvascular dysfunction (CMD) is more frequent in women compared to men, is prevalent in patients with type 2 diabetes and is linked to adverse cardiovascular events. We compared the association between CMD and glycemic control across sexes in patients with chest pain and non-obstructive coronary artery disease (CAD). Methods Patients with chest pain who were found to have non-obstructive CAD (stenosis <40%) at angiography underwent an invasive assessment of endothelial-independent and endothelial–dependent coronary microvascular function. Using a Doppler guidewire, endothelial-independent microvascular function was assessed by measuring the coronary flow velocity in response to intracoronary adenosine and comparing this to baseline to calculate the coronary flow reserve ratio (CFRAdn). A CFRAdn ≤2.5 was considered abnormal. Endothelial-dependent microvascular function was assessed by measuring the percent change in coronary blood flow in response to intracoronary infusions of acetylcholine (%ΔCBFAch), with a %ΔCBFAch ≤50% considered abnormal. Patients were classified as having normal versus abnormal CFRAdn and %ΔCBFAch. Measurements of HbA1c and fasting serum glucose were obtained at the time of catheterization and compared between groups after stratification by sex. Results Between 1993 and 2012, 1,469 patients (mean age 50.4 years, 35% male) underwent coronary angiography and invasive testing for CMD, of which 129 (8.8%) had type 2 diabetes. Fifty one (39.5%) had an abnormal %ΔCBFAch and 49 (38.0%) had an abnormal CFRAdn. Conventional cardiovascular risk factors did not vary significantly between groups. Females with an abnormal CFRAdn or abnormal %ΔCBFAch had a significantly higher HbA1c compared to those with a normal CFRAdn or %ΔCBFAch respectively: HbA1c % (standard deviation) 7.4 (2.1) vs. 6.5 (1.1), p=0.035 and 7.3 (1.9) vs. 6.4 (1.2), p=0.022, respectively. Females with an abnormal CFRAdn had significantly higher fasting serum glucose concentrations compared to those with a normal CFRAdn: fasting serum glucose mg/dL (standard deviation) 144.4 (55.6) vs. 121.9 (28.1), p=0.035. These effects were not observed in men. Amongst female diabetics, a higher HbA1c was significantly associated with any CMD after adjusting for covariates: odds ratio (95% confidence interval) 1.69 (1.01 – 2.86) p=0.049; and a fasting serum glucose >140 mg/dL was significantly associated with an abnormal CFRAdn, 4.28 (1.43–12.81). Conclusion Poor glycemic control is associated with CMD in females with diabete who present with chest pain and non-obstructive CAD. These findings highlight the importance of sex-specific risk stratification models and treatment strategies when managing cardiovascular risk in diabetics. Acknowledgement/Funding Mayo Foundation

Effect of Cigarette Smoking on Fasting Serum Glucose in Healthy Male Population

2019 ◽  
Vol 8 (2) ◽  
pp. 36-39
Author(s):  
Rubiat Naznin ◽  
Sayeda Nazrina ◽  
Shahanaz Parveen ◽  
Nahid Bintay Ansary ◽  
Shamima Nasrin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cigarette Smoking ◽  
Statistical Significance ◽  
Serum Glucose ◽  
Fasting Serum ◽  
Insulin Metabolism ◽  
Fasting Serum Glucose ◽  
Medical College ◽  
Group Ii

Acute effects of cigarette smoking include impaired insulin action that leads to abnormal glucose metabolism. Smoking is an independent risk factor for type 2 diabetes which is one of the global health crises and insulin resistance is one of the main risk factors for cardiovascular disease. This cross-sectional study was done to examine whether fasting serum glucose differs between cigarette smokers compared to non-smokers and to investigate the association of cigarette smoking with the development of impaired fasting glucose and type 2 diabetes. This study was done in the Physiology department of Mymensingh Medical College, an outpatient department of Mymensingh Medical College Hospital, for over a period of one year from July 2014 to June 2015. Fasting serum blood glucose was done by enzymetric colorometric GOD-PAP method in a total of 150 subjects, in which non-smokers were 50 and numbers of smokers were 100 with the duration of smoking 5 - 10 years and >10 years. A questionnaire including data was completed in all cases. The data were checked, coded, and entered into an SPSS 11.5. Statistical significance of difference among the groups was calculated by Students unpaired t' test. P-value <0.05 was considered as a level of significance. Fasting Serum Glucose level was increased gradually with the duration of smoking in smokers than the non-smokers. Results were statistically highly significant. Fasting Serum Glucose gradually increase with the duration of smoking and results were within the physiological limit in two study groups (Group-II A with 5-10 years duration of smoking and Group- II B with more than 10 years duration of smoking) but not statistically significant. This study showed cigarette smoking has deleterious effects on insulin metabolism causing an increase in serum glucose with duration of smoking period. CBMJ 2019 July: Vol. 08 No. 02 P: 36-39

scholarly journals The impact of circuit resistance training on serum glucose, insulin resistance and health related physical fitness in elderly men with type 2 diabetes

2020 ◽  
Vol 12 (3) ◽  
pp. 61-70
Author(s):  
HAMID ARAZI ◽  
ROGHAYEH GHOLIZADEH ◽  
AMIN SOHBATZADEH ◽  
EHSAN EGHBALI
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Resistance Training ◽  
Training Group ◽  
Serum Glucose ◽  
Fasting Serum ◽  
Elderly Men ◽  
Health Related ◽  
The Impact

Background: Obesity and decreased physical activity are the most important factors in the development of type 2 diabetes, which in recent decades has led to an increase in the number of people with this disease. The aim of this study was to investigate the impact of circuit resistance training (CRT) on serum glucose, insulin resistance and health related physical fitness in elderly men with type 2 diabetes. Material and methods: Twenty-two patients with type 2 diabetes (60.99 ±2.93 years) volunteered to participate in this study. They were divided randomly into two groups: training (n = 11) and control (n = 11). Participants in the training group performed a progressive CRT program for ten weeks. In addition, anthropometry variables, muscular strength and endurance were evaluated before and after ten weeks’ CRT. Also, 10 ml of the blood sample was taken from participants to measure fasting serum glucose, fasting serum insulin and insulin resistance. Results: After ten weeks of CRT, the body composition and glucose dropped significantly (P < 0.05) in the training group. Also, muscular endurance, upper and lower body strength in the post-test were significantly higher than the pre-test in the training group (P < 0.05). Conclusions: CRT led to a significant improvement in insulin resistance, fasting serum glucose, BMI, endurance and strength of elderly men with type 2 diabetes. Therefore, this type of resistance training can be useful for improvement in physical and physiological variables of elderly men with type 2 diabetes.

scholarly journals Serum Lipid Profile, Serum Magnesium and Fasting Serum Glucose in Newly Diagnosed Type 2 Diabetic Subjects

2014 ◽  
Vol 7 (1) ◽  
pp. 4-8
Author(s):  
R Karim ◽  
W Nargis ◽  
KA Begum ◽  
SS Subhan ◽  
MN Uddin
Keyword(s):  
Lipid Profile ◽  
Serum Magnesium ◽  
Serum Glucose ◽  
Reference Ranges ◽  
Newly Diagnosed ◽  
Fasting Serum ◽  
Fasting Serum Glucose ◽  
Group I ◽  
Type 2 Diabetic

Type 2 diabetes is considered as a major health burden due to its rising prevalence and disabling, life threatening complications. Dyslipidemia, often coexisting with T2DM as a feature of insulin resistance, is hypothesized to be linked with altered magnesium homeostasis. This study was designed to evaluate the serum magnesium levels and its influence on serum lipids in type 2 diabetics. Lipid profile, serum magnesium (Mg) and fasting serum glucose (FSG) were measured in 30 newly diagnosed normotensive type 2 diabetic patients chosen as cases (Group II) just before introducing any treatment, and was compared with that of 30 healthy controls (Group I). The serum magnesium was found to be significantly lower (p<0.001) and LDL-c was found to be significantly higher (p<0.01) in cases. The correlation analysis revealed a significant negative association of FSG to serum magnesium (r= -0.720), total cholesterol (r=-0.483) and a positive correlation to HDL-c (r=-0.440). However, serum magnesium showed a significant positive relation only with serum HDL-c (r =0.372, p<0.05). Serum magnesium and lipid fractions showed wide range of variation within the normal reference ranges in the newly diagnosed T2D subjects. Further large scale studies are needed to elucidate the association of serum magnesium with lipid profile changes. Estimation of serum magnesium level may prove useful in T2DM with normal or abnormal lipid levels or in those who are prone to develop dyslipidemia or certain complications associated with dyslipidemia. DOI: http://dx.doi.org/10.3329/bjmb.v7i1.18572 Bangladesh J Med Biochem 2014; 7(1): 4-8

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