Inflammatory Mediators in Chronic Obstructive Pulmonary Disease

2005 ◽  
Vol 4 (6) ◽  
pp. 619-625 ◽  
Author(s):  
Kian Chung
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Inflammatory Mediators ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease.

Thorax ◽  
1996 ◽  
Vol 51 (8) ◽  
pp. 819-824 ◽  
Author(s):  
A. M. Schols ◽  
W. A. Buurman ◽  
A. J. Staal van den Brekel ◽  
M. A. Dentener ◽  
E. F. Wouters
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Inflammatory Mediators ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Levels of inflammatory mediators in chronic obstructive pulmonary disease patients with anemia of chronic disease: a case-control study

QJM ◽  
2012 ◽  
Vol 105 (7) ◽  
pp. 657-663 ◽  
Author(s):  
A. K. Boutou ◽  
G. G. Pitsiou ◽  
I. Stanopoulos ◽  
T. Kontakiotis ◽  
G. Kyriazis ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Chronic Disease ◽  
Pulmonary Disease ◽  
Inflammatory Mediators ◽  
Case Control Study ◽  
Case Control ◽  
Chronic Obstructive ◽  
Anemia Of Chronic Disease ◽  
Obstructive Pulmonary Disease ◽  
Control Study

scholarly journals Profiling of Sputum Inflammatory Mediators in Asthma and Chronic Obstructive Pulmonary Disease

Respiration ◽  
2011 ◽  
Vol 83 (1) ◽  
pp. 36-44 ◽  
Author(s):  
M. Bafadhel ◽  
M. McCormick ◽  
S. Saha ◽  
S. McKenna ◽  
M. Shelley ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Inflammatory Mediators ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Interrelationship between serum and sputum inflammatory mediators in chronic obstructive pulmonary disease

2008 ◽  
Vol 41 (3) ◽  
pp. 193-198 ◽  
Author(s):  
L. Bizeto ◽  
A.B. Mazzolini ◽  
M. Ribeiro ◽  
R. Stelmach ◽  
A. Cukier ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Inflammatory Mediators ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

The Potential for Phospholipids in the Treatment of Airway Inflammation: An Unexplored Solution

2021 ◽  
Vol 14 ◽  
Author(s):  
Varsha Komalla ◽  
Meenu Mehta ◽  
Fatima Achi ◽  
Kamal Dua ◽  
Mehra Haghi
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Inflammatory Mediators ◽  
Respiratory Diseases ◽  
Unmet Need ◽  
Structural Features ◽  
The Body ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Immunomodulatory Properties

: Asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) are major inflammatory respiratory diseases. Current mainstay therapy for asthma, and chronic obstructive pulmonary disease are corticosteroids, which have well-established side effect profiles. Phospholipids (PLs) are ubiquitous, diverse compounds with varying functions such as their structural role incell membrane, energy storage, and cell signaling.Recent advances in understanding PLs role as inflammatory mediators in the body as well as their widespread long-standing use as carrier molecules in drug delivery demonstrate the potential application of phospholipids in modulating inflammatory conditions. This review briefly explains the main mechanisms of inflammation in chronic respiratory diseases, currentanti-inflammatory treatments and areas of unmet need. The structural features, roles of endogenous and exogenous phospholipids, including their use as pharmaceutical excipients are reviewed. Current research on the immunomodulatory properties of PLs and their potentialapplication in inflammatory diseasesis the major section of this review. Considering the roles of PLs as inflammatory mediators and their safety profile established in pharmaceutical formulations, these small molecules demonstrate great potential as candidates in respiratory inflammation. Future studies need to focus on the immunomodulatory properties and the underlying mechanisms of phospholipids in respiratory inflammatory diseases.

Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 29 (2) ◽  
pp. 864-872
Author(s):  
Fernanda Borowsky da Rosa ◽  
Adriane Schmidt Pasqualoto ◽  
Catriona M. Steele ◽  
Renata Mancopes
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oral Cavity ◽  
Pulmonary Disease ◽  
Thermal Sensation ◽  
Sensory Function ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Age Related ◽  
Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

The chronic obstructive pulmonary disease strategy

2002 ◽  
Vol 32 (3) ◽  
pp. 64-65 ◽  
Author(s):  
J. Burdon ◽  
R. Edwards
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
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