Transcription Factors as Targets for Cancer Therapy: AP-1 a Potential Therapeutic Target

: SET protein is a multi-functional oncoprotein that is ubiquitously expressed in most tumor cells. Dysregulation of SET has been associated with many types of cancer. Due to ever-accumulating evidence of its strong correlation with both poor prognosis and drug resistance, the targeting of SET is starting to be explored. SET is currently regarded as a potential target for cancer therapy, and several inhibitors are being developed for clinical trials. In this review, the physiological and pathological functions of SET, as well as its antagonists, will be discussed along with the prospects and challenges involved with translating SET inhibitors into bona fide therapeutic options.

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FOXO transcription factors - a potential therapeutic target in civilization diseases.

Farmacja Polska ◽

10.32383/farmpol/132182 ◽

2021 ◽

Vol 76 (11) ◽

pp. 628-632

Author(s):

Agnieszka Przezak ◽

Tomasz Sroczyński ◽

Weronika Bielka

Keyword(s):

Transcription Factors ◽

Therapeutic Target ◽

Potential Therapeutic Target ◽

Foxo Transcription Factors

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A Crosstalk Between Dual-Specific Phosphatases and Dual-Specific Protein Kinases Can Be A Potential Therapeutic Target for Anti-cancer Therapy

Advances in Experimental Medicine and Biology - Protein Kinase-mediated Decisions Between Life and Death ◽

10.1007/978-3-030-49844-3_14 ◽

2021 ◽

pp. 357-382

Author(s):

Basak Celtikci

Keyword(s):

Cancer Therapy ◽

Protein Kinases ◽

Therapeutic Target ◽

Specific Protein ◽

Potential Therapeutic Target ◽

Anti Cancer

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Oxidative phosphorylation as a potential therapeutic target for cancer therapy

International Journal of Cancer ◽

10.1002/ijc.32616 ◽

2019 ◽

Vol 146 (1) ◽

pp. 10-17 ◽

Cited By ~ 19

Author(s):

Valentina Sica ◽

José Manuel Bravo‐San Pedro ◽

Gautier Stoll ◽

Guido Kroemer

Keyword(s):

Cancer Therapy ◽

Oxidative Phosphorylation ◽

Therapeutic Target ◽

Potential Therapeutic Target

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FBXO45 is a potential therapeutic target for cancer therapy

Cell Death Discovery ◽

10.1038/s41420-020-0291-2 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Min Lin ◽

Zhi-wei Wang ◽

Xueqiong Zhu

Keyword(s):

Cancer Therapy ◽

Therapeutic Target ◽

Potential Therapeutic Target

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Chebulinic Acid Suppresses Adipogenesis in 3T3-L1 Preadipocytes by Inhibiting PPP1CB Activity

International Journal of Molecular Sciences ◽

10.3390/ijms23020865 ◽

2022 ◽

Vol 23 (2) ◽

pp. 865

Author(s):

Jinsoo Kim ◽

Dohee Ahn ◽

Sang J. Chung

Keyword(s):

Transcription Factors ◽

Therapeutic Target ◽

Protein Phosphatase ◽

Therapeutic Agent ◽

Protein Phosphatase 1 ◽

Dependent Manner ◽

Terminalia Chebula ◽

Potential Therapeutic Target ◽

Concentration Dependent Manner ◽

Hydrolysis Of

Depletion of protein phosphatase-1 catalytic subunit beta (PPP1CB), a serine/threonine protein phosphatase and potent adipogenic activator, suppresses the differentiation of 3T3-L1 preadipocytes into mature adipocytes. Therefore, PPP1CB is considered as a potential therapeutic target for obesity. We screened 1033 natural products for PPP1CB inhibitors and identified chebulinic acid, which is abundantly present in the seeds of Euphoria longana and fruits of Terminalia chebula. Chebulinic acid strongly inhibited the hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate by PPP1CB (IC50 = 300 nM) and demonstrated potent antiadipogenic effects in 3T3-L1 preadipocytes in a concentration-dependent manner. Additional studies have demonstrated that chebulinic acid suppresses early differentiation by downregulating key transcription factors that control adipogenesis in 3T3-L1 cells. These results suggested that chebulinic acid may be a potential therapeutic agent for treating obesity by inhibiting PPP1CB activity.

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