Drug Delivery Systems with Modified Release for Systemic and Biophase Bioavailability

2012 ◽  
Vol 7 (4) ◽  
pp. 282-317 ◽  
Author(s):  
Sorin E. Leucuta
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Modified Release

Hydrogels for modified-release drug delivery systems

2021 ◽  
Vol 28 ◽  
Author(s):  
Aleksandra Zielińska ◽  
Piotr Eder ◽  
Lucas Rannier ◽  
Juliana C. Cardoso ◽  
Patrícia Severino ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Search Strategy ◽  
Delivery Systems ◽  
Global Market ◽  
Modified Release ◽  
Safety And Efficacy ◽  
Area Of Interest ◽  
Release Drug

Abstract: Hydrogels for the modified-release drug delivery systems is a continuously growing area of interest for the pharmaceutical industry. According to the global market, the use of polymers in this area is projected to reach $31.4 million by 2027. This review discusses the recent advances and perspectives of hydrogel in drug delivery systems for oral, parenteral, nasal, topical, and ophthalmic. The search strategy did in January 2021, and it conducted an extensive database to identify studies published from January 2010 to December 2020.We described the main characteristic of the polymers to obtain an ideal hydrogel for a specific route of administration and the formulations that was a highlight in the literature. It concluded that the hydrogels are a set useful to decrease the number of doses, side effects, promote adhesion of patient and enhances the bioavailability of the drugs improving the safety and efficacy of the treatment.

scholarly journals USE OF SORPTION PROCESSES IN THE TECHNOLOGY OF DRUG DELIVERY SYSTEMS

2019 ◽  
Vol 7 (1) ◽  
pp. 4-12 ◽  
Author(s):  
A. V. Bondarev ◽  
E. T. Zhilyakova
Keyword(s):  
Drug Delivery ◽  
Activated Carbon ◽  
Drug Delivery Systems ◽  
Active Pharmaceutical Ingredient ◽  
Delivery Systems ◽  
Modified Release ◽  
Technical Literature ◽  
Analysis And Synthesis ◽  
Medicinal Substances ◽  
Dioctahedral Smectite

The aimof this research is the review of scientific and technical literature regarding possibility of using sorption processes in the technology of drug delivery systems.Materials and methods. The materials are the following electronic resources: eLIBRARY, CyberLeninka, PubMed. The methods of review are analysis and synthesis. The study covers the scientific literature from 1996 up to the present time.Results.Sorbents are used as carriers for various medicinal peroral substances, they are also dispensers of various compounds in the form of polymeric eye films and stents in the human body. The delivery of medicinal substances occurs with the help of sorption processes of mass transfer. Currently, the following medical substances are used as carriers for medicinal substances: activated carbon, mineral sorbents (medical clays, synthetic sorbents), polymers and their biosimilars. 6 groups of pharmaceutical substances are registered for the production of enterosorbents in Russia and they can be used as sorbent carriers in the sorption drug system. They are: activated carbon, colloidal silicon dioxide, polyvinylpyrrolidone, dioctahedral smectite, polymethylsiloxane polyhydrate. As a result of the study, the model of the sorption drug system has been developed. It consists of sorbent carrier, active pharmaceutical ingredient and excipients that provide the desorption. Desorption of the active pharmaceutical ingredient may contribute to its modified release. The technology for obtaining sorption medicinal systems requires further study and development of modeling methods, searching for experimental pharmacological models and technological methods, which make it possible to obtain sorption dosage form with modified release.Conclusion.The review of the sorption processes used in the technology of drug delivery systems has been carried out. The model of the sorption drug system has been developed.

Oral Modified Drug Release Solid Dosage Form with Special Reference to Design; An Overview

2020 ◽  
Vol 12 (1) ◽  
pp. 16-25
Author(s):  
Senthilkumar Murugesan ◽  
Byran Gowramma ◽  
Kaviarasan Lakshmanan ◽  
Veera Venkata Satyanarayana Reddy Karri ◽  
Arun Radhakrishnan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Oral Drug Delivery ◽  
Delivery Systems ◽  
Oral Drug ◽  
Active Surface Area ◽  
Prolonged Release ◽  
Modified Release ◽  
Wide Range

Oral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage form and this oral route provides maximum active surface area among all drug delivery system for administration of various drugs. The attractiveness of these dosage forms is due to awareness of toxicity and ineffectiveness of drugs when administered by oral conventional method in the form of tablets and capsules. Usually, conventional dosage form produces wide range of fluctuation in drug concentration in the bloodstream and tissues with consequent undesirable toxicity and poor efficiency. The maintenance of concentration of drug in plasma within therapeutic index is very critical for effective treatment. These factors as well as factors such as repetitive dosing and unpredictable absorption lead to the concept of oral modified drug delivery systems like Sustained release, prolonged release, modified release, extended release. These formulations are used to identify drug delivery systems that are designed to achieve or extend therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. This review describes the basic information regarding modified release dosage form like designed to release their medication in controlled manner, criteria for selecting modified release dosage form and factors influencing the dosage and release pattern.

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