scholarly journals USE OF SORPTION PROCESSES IN THE TECHNOLOGY OF DRUG DELIVERY SYSTEMS

2019 ◽  
Vol 7 (1) ◽  
pp. 4-12 ◽  
Author(s):  
A. V. Bondarev ◽  
E. T. Zhilyakova
Keyword(s):  
Drug Delivery ◽  
Activated Carbon ◽  
Drug Delivery Systems ◽  
Active Pharmaceutical Ingredient ◽  
Delivery Systems ◽  
Modified Release ◽  
Technical Literature ◽  
Analysis And Synthesis ◽  
Medicinal Substances ◽  
Dioctahedral Smectite

The aimof this research is the review of scientific and technical literature regarding possibility of using sorption processes in the technology of drug delivery systems.Materials and methods. The materials are the following electronic resources: eLIBRARY, CyberLeninka, PubMed. The methods of review are analysis and synthesis. The study covers the scientific literature from 1996 up to the present time.Results.Sorbents are used as carriers for various medicinal peroral substances, they are also dispensers of various compounds in the form of polymeric eye films and stents in the human body. The delivery of medicinal substances occurs with the help of sorption processes of mass transfer. Currently, the following medical substances are used as carriers for medicinal substances: activated carbon, mineral sorbents (medical clays, synthetic sorbents), polymers and their biosimilars. 6 groups of pharmaceutical substances are registered for the production of enterosorbents in Russia and they can be used as sorbent carriers in the sorption drug system. They are: activated carbon, colloidal silicon dioxide, polyvinylpyrrolidone, dioctahedral smectite, polymethylsiloxane polyhydrate. As a result of the study, the model of the sorption drug system has been developed. It consists of sorbent carrier, active pharmaceutical ingredient and excipients that provide the desorption. Desorption of the active pharmaceutical ingredient may contribute to its modified release. The technology for obtaining sorption medicinal systems requires further study and development of modeling methods, searching for experimental pharmacological models and technological methods, which make it possible to obtain sorption dosage form with modified release.Conclusion.The review of the sorption processes used in the technology of drug delivery systems has been carried out. The model of the sorption drug system has been developed.

Hydrogels for modified-release drug delivery systems

2021 ◽  
Vol 28 ◽  
Author(s):  
Aleksandra Zielińska ◽  
Piotr Eder ◽  
Lucas Rannier ◽  
Juliana C. Cardoso ◽  
Patrícia Severino ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Search Strategy ◽  
Delivery Systems ◽  
Global Market ◽  
Modified Release ◽  
Safety And Efficacy ◽  
Area Of Interest ◽  
Release Drug

Abstract: Hydrogels for the modified-release drug delivery systems is a continuously growing area of interest for the pharmaceutical industry. According to the global market, the use of polymers in this area is projected to reach $31.4 million by 2027. This review discusses the recent advances and perspectives of hydrogel in drug delivery systems for oral, parenteral, nasal, topical, and ophthalmic. The search strategy did in January 2021, and it conducted an extensive database to identify studies published from January 2010 to December 2020.We described the main characteristic of the polymers to obtain an ideal hydrogel for a specific route of administration and the formulations that was a highlight in the literature. It concluded that the hydrogels are a set useful to decrease the number of doses, side effects, promote adhesion of patient and enhances the bioavailability of the drugs improving the safety and efficacy of the treatment.

Photo-triggerable liposomal drug delivery systems: from simple porphyrin insertion in the lipid bilayer towards supramolecular assemblies of lipid–porphyrin conjugates

2019 ◽  
Vol 7 (11) ◽  
pp. 1805-1823 ◽  
Author(s):  
Julien Massiot ◽  
Véronique Rosilio ◽  
Ali Makky
Keyword(s):  
Drug Delivery ◽  
Lipid Bilayer ◽  
Drug Delivery Systems ◽  
Active Pharmaceutical Ingredient ◽  
Delivery Systems ◽  
Supramolecular Assemblies ◽  
Liposomal Drug ◽  
Spatio Temporal ◽  
Nanoparticulate Systems ◽  
Liposomal Drug Delivery

Light-responsive liposomes are considered nowadays as one of the most promising nanoparticulate systems for the delivery and release of an active pharmaceutical ingredient (API) in a spatio-temporal manner.

scholarly journals Strategies in poorly soluble drug delivery systems

2019 ◽  
Vol 73 (1) ◽  
pp. 81
Author(s):  
Magdalena Szaniawska
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Point Of View ◽  
Water Soluble ◽  
Biologically Active ◽  
Water Soluble Drugs ◽  
Medicinal Substances ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

<p>The form of the active drug administered to patients is important as far as effectiveness of the disease therapy is concerned. From this point of view modifications of medicinal substances are searched for that the obtained compounds have the best physicochemical and pharmacodynamic properties. Pharmaceutical companies allocate significant funds for this type of research. The key property that needs to be improved is the solubility of biologically active substances. This is related to the fact that over 40% of drugs available on the pharmaceutical market are characterized by low solubility in water.</p><p>Thus, the paper describes the most important strategies used in the poorly soluble drug delivery systems, e.g. physical and chemical modifications, formulation based, modification of partition coefficient and lipid systems. The authors discussed various techniques used to enhance solubility of poorly water soluble drugs with their advantages and limitations.</p>

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