To Analyze the Amelioration of Phenobarbital Induced Oxidative Stress by Erucin, as Indicated by Biochemical and Histological Alterations

2016 ◽  
Vol 16 (11) ◽  
pp. 1445-1454 ◽  
Author(s):  
Rohit Arora ◽  
Sakshi Bhushan ◽  
Rakesh Kumar ◽  
Rahul Mannan ◽  
Pardeep Kaur ◽  
...  
Toxicon ◽  
2018 ◽  
Vol 144 ◽  
pp. 55-60 ◽  
Author(s):  
Ghada Souid ◽  
Nouha Souayed ◽  
Zohra Haouas ◽  
Khira Maaroufi

2004 ◽  
Vol 120 (1-3) ◽  
pp. 185-193 ◽  
Author(s):  
Stelios F Assimakopoulos ◽  
Constantine E Vagianos ◽  
George Zervoudakis ◽  
Kriton S Filos ◽  
Christos Georgiou ◽  
...  

2018 ◽  
Vol 2 ◽  
pp. 239784731881279 ◽  
Author(s):  
Olusegun Kayode Afolabi ◽  
Adedoja Dorcas Wusu ◽  
Regina Ugbaja ◽  
John Olabode Fatoki

The present study was designed to investigate aluminium phosphide (ALP)-induced testicular toxicity, including its effects on sperm parameters and histological alterations in Wistar rats, and the possible protective role of hesperidin (HSD). Oral administration of ALP at 1.15 mg/kg body weight (1/10 LD50) for 30 days resulted in a significant increase in testicular malondialdehyde, lipid hydroperoxides, and oxidized protein levels. These indicators of oxidative stress were accompanied by decreased activity of the antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, followed by a drastic reduction in the non-enzymatic antioxidant indices of glutathione and total antioxidant capacity when compared to control. Furthermore, ALP treatment produced a marked reduction in sperm count, motility and viability while increasing abnormal sperm morphology and adverse histopathological changes in testis. Co-administration with HSD significantly ameliorated ALP-induced testicular damage by suppressing oxidative stress indices and enhancing antioxidant status while also improving the sperm parameters and histological alterations in ALP-treated rats. The results of the present study indicated that testicular toxic effects of ALP are due to oxidative imbalance and that HSD could be a potential therapeutic agent against ALP-induced testicular damage.


2012 ◽  
Vol 92 (15) ◽  
pp. 3002-3006 ◽  
Author(s):  
Sauganth Paul ◽  
Abhilash Mohanan ◽  
Mathews V Varghese ◽  
Manju Alex ◽  
Harikumaran Nair

Author(s):  
Sebastián E. Sabatini ◽  
Iara Rocchetta ◽  
Daniel E. Nahabedian ◽  
Carlos M. Luquet ◽  
Maria Rosa Eppis ◽  
...  

2016 ◽  
Vol 173 (1) ◽  
pp. 185-193 ◽  
Author(s):  
Jia Cheng ◽  
Wentao Fan ◽  
Xiaona Zhao ◽  
Yanhan Liu ◽  
Ziqiang Cheng ◽  
...  

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