Synthesis, Characterization of 4-Anilino-6,7-Dimethoxy Quinazoline Derivatives as Potential Anti-Angiogenic Agents

2018 ◽  
Vol 17 (14) ◽  
Author(s):  
Preethi Saligrama Devegowda ◽  
Kyathegowdanadoddi Srinivasa Balaji ◽  
Doddakunche Shivaramu Prasanna ◽  
Toreshettahally Ramesh Swaroop ◽  
Vivek Hamse Kameshwar ◽  
...  
Keyword(s):  
Quinazoline Derivatives

Spectral Characterization of Novel 3-Phenyl-2-Substituted Quinazoline and Fused Quinazoline Derivatives

2013 ◽  
Vol 43 (11) ◽  
pp. 1484-1490 ◽  
Author(s):  
Mahmoud R. Mahmoud ◽  
Wael S. I. Abou-Elmagd ◽  
Salwa S. Abdelwahab ◽  
El-Sayed A. Soliman
Keyword(s):  
Spectral Characterization ◽  
Quinazoline Derivatives

Characterization of a Perhydro-5,6-di(methylene)-2,4-dioxopyrimidine Intermediate and Its Cycloaddition Reactions Leading to Quinazoline Derivatives

1989 ◽  
Vol 18 (12) ◽  
pp. 2115-2116 ◽  
Author(s):  
Michihiko Noguchi ◽  
Kenji Doi ◽  
Yasutoshi Kiriki ◽  
Shoji Kajigaeshi
Keyword(s):  
Cycloaddition Reactions ◽  
Quinazoline Derivatives

scholarly journals Synthesis and Spectral Characterization of 4,7-Dichloro-6-nitroquinazoline

Molbank ◽  
10.3390/m1134 ◽  
2020 ◽  
Vol 2020 (2) ◽  
pp. M1134 ◽  
Author(s):  
Thi Ngoc Nguyen ◽  
Thi Huong Tran ◽  
Nguyet Suong Huyen Dao ◽  
Van Giang Nguyen ◽  
Dinh Luyen Nguyen ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Therapeutic Potential ◽  
Locally Advanced ◽  
Intermediate Compound ◽  
Chlorobenzoic Acid ◽  
Ft Ir ◽  
Important Intermediate ◽  
Quinazoline Derivatives ◽  
First Time

Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor (TKI) in the form of a dimaleate salt which is indicated for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC). The most scalable route for the synthesis of this drug was reported in two Boehringer Ingelheim patents, in which the title compound, 4,7-dichloro-6-nitroquinazoline (IV), is an important intermediate. Compound IV is also present in a number of synthetic pathways for various 4,7-disubstituted quinazoline derivatives displaying high therapeutic potential. However, no detailed characterization of this popular compound has been reported, possibly due to its high instability. In this paper, IV was prepared in an overall yield of 56.1% by a 3-step process (condensation, nitration, and chlorination) from 2-amino-4-chlorobenzoic acid (I). The target compound has been for the first time fully characterized by melting point, mass-spectrometry, FT-IR, 1H-NMR and 13C-NMR spectroscopies.

Synthesis and Characterization of Palladium(II) Complexes with Substituted Dihydrobenzoimidazo Quinazoline Derivatives

2017 ◽  
Vol 13 (2) ◽  
pp. 1-15
Author(s):  
Rita Bhattacharjee Virupaiah Gayathri
Keyword(s):  
Metal Ion ◽  
Synthesis And Characterization ◽  
Planar Geometry ◽  
Conductivity Measurements ◽  
Spectral Techniques ◽  
Mass Spectral ◽  
Square Planar ◽  
Elemental Analyses ◽  
Quinazoline Derivatives

A series of palladium(II) halo complexes of the types [PdX 2 L 2 ].nH 2 O {n = 0, X = Cl, L = L 2 , L 4 and L 5 ; X = Br, L = L 2 ; n = 1, X = Cl, L = L 1 and L 3 } and Pd 2 X 4 L 3 [X = Br, L = L 1 , L 3 , L 4   and L 5 ] were prepared where L is 6-R-5,6- dihydrobenzoimidazo quinazoline (R-Diq; where R = ethyl: L 1 / n or i-propyl: L 2 , L 3 / n or i-butyl: L 4 , L 5 ) and characterized by elemental analyses, conductivity measurements, TGA, infrared, electronic, NMR and mass spectral techniques. Based    on these studies monomeric/dimeric structure with a square planar geometry around the metal ion was proposed for all the complexes. Some of the complexes were investigated for anti-microbial activity.

scholarly journals Preparation and characterization of graphitic carbon nitride-supported l-arginine as a highly efficient and recyclable catalyst for the one-pot synthesis of condensation reactions

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hossein Ghafuri ◽  
Zeinab Tajik ◽  
Nastaran Ghanbari ◽  
Peyman Hanifehnejad
Keyword(s):  
Carbon Nitride ◽  
Graphitic Carbon ◽  
Graphitic Carbon Nitride ◽  
The Novel ◽  
One Pot ◽  
Ft Ir ◽  
Quinazoline Derivatives ◽  
The One ◽  
Reaction Media

AbstractIn this work, graphitic carbon nitride-supported l-arginine (g-C3N4@l-arginine) nanocatalyst was synthesized and evaluated using FT-IR, EDX, XRD, TGA, and FESEM analyses. The performance of the prepared nanocatalyst was examined in the synthesis of 1,4-dihydropyridine, 4H-chromene, and 2,3-dihydro quinazoline derivatives. The novel g-C3N4@l-arginine nanocatalyst showed high thermal stability, easy separation from reaction media, the capability to be used in various multicomponent reactions, and acceptable reusability.

scholarly journals Synthesis and characterization of some new 4-heteroaryl quinazoline and fused triazolo quinazoline derivatives

2016 ◽  
Vol 7 (1) ◽  
pp. 128-134
Author(s):  
Yaser Abdel-Moemen El-Badry ◽  
Ekhlass Nassar ◽  
Mahr Abdel-Aziz El-Hashash
Keyword(s):  
Synthesis And Characterization ◽  
Quinazoline Derivatives

scholarly journals Preparation And Characterization Of g-C3N4 @ L-Arginine As A Highly - Efficient And Recyclable Catalyst For The Synthesis of 1, 4-Dihydropyridine, 4H-Chromene, And 2, 3-Dihydro Quinazoline Derivatives

2021 ◽  
Author(s):  
Zeinab Tajik ◽  
Hossein Ghafuri ◽  
Nastaran Ghanbari ◽  
Payman Hanifehnejad
Keyword(s):  
Thermal Stability ◽  
Multicomponent Reactions ◽  
Media Use ◽  
High Thermal Stability ◽  
Recyclable Catalyst ◽  
High Yield ◽  
Ft Ir ◽  
Quinazoline Derivatives ◽  
Reaction Media

Abstract In this work, the nanocatalyst of g-C3N4@L-arginine was prepared that synthesis of it in comparison with the synthesis of other catalysts was convenient; initially, this prepared nanocatalyst was evaluated and verified by FT-IR, EDX, XRD, TGA, and FESEM analysis, and in the next step, the performance of nanocatalyst in the synthesis of 1, 4-dihydropyridine, 4H-chromene, and 2, 3-dihydro quinazoline derivatives were examined with high yield. Properties such as high thermal stability, easy separation of reaction media, use in various multicomponent reactions, and reusability have caused that this novel nanocatalyst was changed into a unique catalyst in its own age.

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