scholarly journals Synthesis and Spectral Characterization of 4,7-Dichloro-6-nitroquinazoline

Molbank ◽  
10.3390/m1134 ◽  
2020 ◽  
Vol 2020 (2) ◽  
pp. M1134 ◽  
Author(s):  
Thi Ngoc Nguyen ◽  
Thi Huong Tran ◽  
Nguyet Suong Huyen Dao ◽  
Van Giang Nguyen ◽  
Dinh Luyen Nguyen ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Therapeutic Potential ◽  
Locally Advanced ◽  
Intermediate Compound ◽  
Chlorobenzoic Acid ◽  
Ft Ir ◽  
Important Intermediate ◽  
Quinazoline Derivatives ◽  
First Time

Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor (TKI) in the form of a dimaleate salt which is indicated for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC). The most scalable route for the synthesis of this drug was reported in two Boehringer Ingelheim patents, in which the title compound, 4,7-dichloro-6-nitroquinazoline (IV), is an important intermediate. Compound IV is also present in a number of synthetic pathways for various 4,7-disubstituted quinazoline derivatives displaying high therapeutic potential. However, no detailed characterization of this popular compound has been reported, possibly due to its high instability. In this paper, IV was prepared in an overall yield of 56.1% by a 3-step process (condensation, nitration, and chlorination) from 2-amino-4-chlorobenzoic acid (I). The target compound has been for the first time fully characterized by melting point, mass-spectrometry, FT-IR, 1H-NMR and 13C-NMR spectroscopies.

Characterization of SrBi2Nb2O9 Thin Films Prepared by Sol Gel Technique

1996 ◽  
Vol 459 ◽  
Author(s):  
E. Ching-Prado ◽  
W. Pérez ◽  
A. Reynés-Figueroa ◽  
R. S. Katiyar ◽  
D. Ravichandran ◽  
...  
Keyword(s):  
Thin Films ◽  
Raman Band ◽  
Sol Gel ◽  
Orthorhombic Symmetry ◽  
X Ray Diffraction ◽  
Ft Ir ◽  
Gel Technique ◽  
High Degree ◽  
First Time

ABSTRACTThin films of SrBi2Nb2O9 (SBN) with thicknesses of 0.1, 0.2, and 0.4 μ were grown by Sol-gel technique on silicon, and annealed at 650°C. The SBN films were investigated by Raman scatering for the first time. Raman spectra in some of the samples present bands around 60, 167, 196, 222, 302, 451, 560, 771, 837, and 863 cm−1, which correspond to the SBN formation. The study indicates that the films are inhomogeneous, and only in samples with thicknesses 0.4 μ the SBN material was found in some places. The prominent Raman band around 870 cm−1, which is the A1g mode of the orthorhombic symmetry, is assigned to the symmetric stretching of the NbO6 octahedrals. The frequency of this band is found to shift in different places in the same sample, as well as from sample to sample. The frequency shifts and the width of the Raman bands are discussed in term of ions in non-equilibrium positions. FT-IR spectra reveal a sharp peak at 1260 cm−1, and two broad bands around 995 and 772 cm−1. The bandwidths of the latter two bands are believed to be associated with the presence of a high degree of defects in the films. The experimental results of the SBN films are compared with those obtained in SBT (T=Ta) films. X-ray diffraction and SEM techniques are also used for the structural characterization.

Article

1998 ◽  
Vol 76 (11) ◽  
pp. 1730-1736
Author(s):  
Mathew D Halls ◽  
Ricardo Aroca
Keyword(s):  
Ab Initio ◽  
Normal Modes ◽  
Light Emitting ◽  
Solid Films ◽  
Ft Ir ◽  
First Time ◽  
Mode Assignment ◽  
Transmission And Reflection ◽  
Ft Ir Spectroscopy

The vibrational spectra of one of the most commonly used light-emitting materials for organic electroluminescence (EL) devices, tris(8-hydroxyquinoline)aluminum (Alq3), is presented. The geometry and normal modes of fac-Alq3 isomer in the ground state have been computed for the first time using ab initio methods (HF/6-31G*) to aid in discussion of normal-mode assignment. Normal inelastic scattering excited at 633 nm and low-temperature FT-Raman in addition to the infrared spectra of this material are reported. The vibrational characterization of thin solid films of the material was attempted using transmission and reflection-absorption FT-IR spectroscopy (RAIRS) on smooth silver films.Key words: tris(8-hydroxyquinoline)aluminum, Alq3, ab initio, assignments, infrared, Raman, thin films.

scholarly journals Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (Papaver somniferum)

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Ibrahim Bulduk ◽  
Fulya Taktak
Keyword(s):  
Papaver Somniferum ◽  
Toxicity Profile ◽  
Isolation And Characterization ◽  
Cancer Types ◽  
Ft Ir ◽  
Low Toxicity ◽  
Increasing Demand ◽  
Isolated Compound ◽  
First Time

Noscapine, a phthalideisoquinoline alkaloid derived from opium, has been used in the treatment of various cancer types. Its low-toxicity profile has increased attention to this alkaloid. With regard to increasing demand for this compound, we developed a new method for isolation of noscapine from dried capsules ofPapaver somniferum. Noscapine was successfully isolated from poppy capsules for the first time and the purity of the isolated compound was determined to be over 99.59% by HPLC analysis. The structure of noscapine was confirmed by NMR, NMR, FT-IR, elemental analysis, and HR-ESI-MS methods.

Preparation and Characterization of W@SiO2 Shielding Composite Microsphere

2015 ◽  
Vol 1120-1121 ◽  
pp. 260-263
Author(s):  
Zuo Sheng li ◽  
Yan Zhang ◽  
Yu Jian Liu ◽  
Jun Fang ◽  
Wei Ling Luan
Keyword(s):  
Sol Gel ◽  
Shell Element ◽  
Core Element ◽  
Composite Microsphere ◽  
Composite Microspheres ◽  
Free Silica ◽  
Transmission Electron ◽  
Ft Ir ◽  
First Time

W@SiO2 shielding composite microspheres were prepared by Sol-gel method for the first time. The component and morphology were investigated by Fourier transform infrared (FT-IR) spectra, Transmission electron microscopy (TEM) and Energy dispersive X-ray spectroscopy (EDX). The results reveal that polyvinylpyrrolidone (PVP) was introduced to the surface of tungsten nanoparticle successfully, and tungsten nanoparticle had been coated with silica. The appropriate hydrolysis reaction time is 3h, core-shell structure W@SiO2 shielding composite microsphere can be synthesized and free silica decrease sharply. Core element and shell element of W@SiO2 shielding composite microspheres were proved to be tungsten and silica respectively.

scholarly journals Production of Methanol from Aqueous CO2 by Using Co3O4 Nanostructures as Photocatalysts

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Salvador Pocoví-Martínez ◽  
Inti Zumeta-Dube ◽  
David Diaz
Keyword(s):  
Mixed Valence ◽  
Synthesis Methods ◽  
Magnetization Curves ◽  
Simulated Solar Light ◽  
Nanoparticle Aggregates ◽  
Ft Ir ◽  
Sacrificial Agent ◽  
First Time ◽  
Co3o4 Nanostructures

In this work, we report for the first time the photocatalytic activity of Co3O4 nanostructures for the reduction of aqueous CO2 to methanol (MeOH). This could be considered a simple example of artificial photosynthesis. The photocatalysis experiments were developed under simulated solar light of 100 mW/cm2 and without using any sacrificial agent. To carry out this study, nanostructured mixed valence cobalt oxide (Co3O4) powders, with porous nanoparticle aggregates of different morphologies, have been prepared by two synthesis methods. The characterization of structural (PXRD, XPS, SEM, and TEM) and optical (UV-vis-NIR, Raman, and FT-IR) properties, magnetization curves, and surface area (BET) was accomplished.

Octa-substituted metallophthalocyanines bearing (2,3-dihydrobenzo-1,4-benzodioxin-2-yl)methoxy and chloro groups: Synthesis, characterization and photophysicochemical studies

2020 ◽  
Vol 24 (04) ◽  
pp. 548-562 ◽  
Author(s):  
Semih Gorduk
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Synthesis And Characterization ◽  
Different Types ◽  
Ft Ir ◽  
Yield Values ◽  
Characterization Studies ◽  
First Time ◽  
Potential Use

In this study, the synthesis and characterization of novel 4-chloro-5-((2,3-dihydrobenzo-1,4-benzodioxin-2-yl)methoxy)phthalonitrile (1) and its peripherally octa-substituted Zn(II) (Pc-Zn), In(III) (PcInCI) and Mg(II) (Pc-Mg) phthalocyanine (Pc) derivatives are reported for the first time. FT-IR, elemental analysis, UV-vis, NMR and MS techniques were used for characterization studies of the compounds. Aggregation properties of the compounds were evaluated in DMF, DMSO and THF solvents in different concentrations, and the compounds did not tend to aggregate in these solvents. In addition, photophysicochemical properties such as fluorescence, photodegradation and singlet oxygen quantum yield of the compounds were examined in DMSO, DMF and THF solvents to show the potential use of these novel compounds as photosensitizers for photodynamic therapy (PDT). The effects of zinc, indium and magnesium metals, octa substitutions in peripheral positions and different types of solvents on photophysicochemical properties were investigated. The singlet oxygen quantum yield values of compounds ranged from 0.27 to 0.77 in different solvents. As a result of the photophysicochemical properties, these compounds can be considered as potential candidates for PDT, applications.

scholarly journals Preparation and Characterization of Macroalgae Biochar Nanomaterials with Highly Efficient Adsorption and Photodegradation Ability

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1709 ◽  
Author(s):  
Yarui Zhou ◽  
Hailong Zhang ◽  
Lu Cai ◽  
Jian Guo ◽  
Yaning Wang ◽  
...  
Keyword(s):  
Transition Metal Oxides ◽  
High Specific Surface Area ◽  
Test Results ◽  
Order Model ◽  
Highly Efficient ◽  
Pseudo Second Order ◽  
Ft Ir ◽  
Dyes Adsorption ◽  
First Time

In this study, carbonized kelp biochar (AKB) modified by KOH impregnation and photocatalytic Bi2MoO6/AKB composite (BKBC) nanomaterials were the first time successfully synthesized for efficient removal of dyes in aqueous solution. BET, XRD, FT-IR, and SEM were employed to characterize as-prepared samples. UV-vis and other test results indicated that the removal efficiency of methylene blue (MB) was 61.39% and 94.12% for BKBC and AKB, respectively, which was up to 13 times and 20 times higher in comparison with pure Bi2MoO6 (PBM). In addition, the equilibrium adsorption capacity of MB could reach up to 324.1 mg/g for AKB. This high dyes adsorption performance could be likely attributed to its high specific surface area (507.177 m2/g) and its abundant presence of various functional groups such as –OH and =C–H on AKB. Particularly, the existing of amorphous carbon and transition metal oxides, such as Fe2O3 and Mn5O8, could be beneficial for the photodegradation of MB for AKB. Meanwhile, experimental data indicated that adsorption kinetics complied with the pseudo-second order model well, and all of the tests had satisfactory results in terms of the highly efficient adsorption and photodegradation activity of AKB nanomaterials, which suggested its great potential in wastewater treatment.

scholarly journals Chemical and biological characterization of sulfated chitosan oligomer as heparin mimics

2021 ◽  
pp. 096739112110350
Author(s):  
Samet Kocabay ◽  
Mehmet Refik Bahar ◽  
Suat Tekin ◽  
Recep Akkaya ◽  
Birnur Akkaya
Keyword(s):  
Potential Candidate ◽  
Biological Characterization ◽  
Scanning Calorimetry ◽  
Chitosan Oligomer ◽  
Bond Stretching ◽  
Ft Ir ◽  
Spectrum Band ◽  
First Time ◽  
Mcf 7

In the present study, chitosan oligomer was modified to sulfated chitosan oligomer (ShCsO) to mimic heparin. Its chemical structure was determined by infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and thermogravimetric analysis. The results showed that the FT-IR spectrum band at 799 cm−1 corresponds to C–O–S and that at 1212 cm−1 corresponds to S=O bond stretching, which prove that the sulfate groups are incorporated into chitosan oligomer successfully. The antimicrobial activity of ShCsO against to Bacillus subtilis in 1% concentration was 89.1 ± 1.7% . The IC50 (μg/ml) of ShCsO was 67.75, 56.07, 85.47, and 84.68 for A2780, MCF-7, DU-145, and HepG2, respectively. The results show that this newly synthesized material is a potential candidate to heparin-like chitosan derivatives. According to the literature, it was the first time that chitosan oligomer was modified to mimic heparin.

scholarly journals Preparation and characterization of graphitic carbon nitride-supported l-arginine as a highly efficient and recyclable catalyst for the one-pot synthesis of condensation reactions

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hossein Ghafuri ◽  
Zeinab Tajik ◽  
Nastaran Ghanbari ◽  
Peyman Hanifehnejad
Keyword(s):  
Carbon Nitride ◽  
Graphitic Carbon ◽  
Graphitic Carbon Nitride ◽  
The Novel ◽  
One Pot ◽  
Ft Ir ◽  
Quinazoline Derivatives ◽  
The One ◽  
Reaction Media

AbstractIn this work, graphitic carbon nitride-supported l-arginine (g-C3N4@l-arginine) nanocatalyst was synthesized and evaluated using FT-IR, EDX, XRD, TGA, and FESEM analyses. The performance of the prepared nanocatalyst was examined in the synthesis of 1,4-dihydropyridine, 4H-chromene, and 2,3-dihydro quinazoline derivatives. The novel g-C3N4@l-arginine nanocatalyst showed high thermal stability, easy separation from reaction media, the capability to be used in various multicomponent reactions, and acceptable reusability.

scholarly journals Synthesis and Characterization of Aminophosphonates Zirconium as New Mesoporous Materials

2012 ◽  
Vol 9 (3) ◽  
pp. 1320-1326
Author(s):  
Liang Zhou
Keyword(s):  
Experimental Data ◽  
Zirconium Phosphate ◽  
Layer Structure ◽  
Nitrogen Adsorption ◽  
Synthesis And Characterization ◽  
Good Thermal Stability ◽  
Ft Ir ◽  
Adsorption Desorption ◽  
First Time

A serial of aminophosphonates zirconium with the different arm lengths of –(CH2)n– organic chains (n=2–6) was synthesized for the first time. These compounds are characterized by FT-IR, SEM, TEM, TG and nitrogen adsorption-desorption. And based on the experimental data, these materials not only have layer structure mesoporous and good thermal stability such as zirconium phosphate, but also can be adjusted the layer distance, pore size and pore volume. So aminophosphonates zirconium posses special excellent properties and will have potential prospect applications.

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