Hepatitis E genotype 1 outbreak in Jharkhand, India: A descriptive analysis

2020 ◽  
Vol 20 ◽  
Author(s):  
Neelam Mehta ◽  
Minakshi Gupta ◽  
Minakshi Mishra ◽  
Santosh Kumar Singh
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis E Virus ◽  
Acute Viral Hepatitis ◽  
Demographic Data ◽  
Descriptive Analysis ◽  
Hepatitis E ◽  
Genotype 1 ◽  
Rna Detection ◽  
Waterborne Outbreak ◽  
Time Of Admission

Introduction: A waterborne outbreak of hepatitis E virus occurred in the Jamshedpur city of Jharkhand from March 2018 to October2018. In the present study, we attempt to study the hepatitis E virus outbreak clinically, serologically and etiologically. Methods: Five hundredand eighty four clinically and biochemically documented cases were screened for the hepatotropic viral markers (HepatitisA, B, C, and E) by the ELISA. Demographic data such as gender, age,clinical diagnosis, location, the outcome, time of admission were extracted from the online hospital management system.Water samples from affected area were tested for HEV RNA detection. Genotyping of HEV virus was carried out by sequencing and phylogenetic analysis. Result: Hepatitis E genotype 1 was confirmed as the major etiological agent inthis outbreak due to faecal contamination of drinking water supply while establishing illegal water connections. Mixed infection of HEV-HAV (5.31%) or HEV-HBV (0.91%) was also detected in the present series of acute viral hepatitis. Conclusions: The study highlights the importance of screening forboth enterically transmitted hepatotropic viral markers as well as the parenterally transmitted hepatotropic viral markersduring outbreaks of acute viral hepatitis.

scholarly journals Case report: Acute Hepatitis E Infection with Co-Existent Glucose-6-Phosphate Dehydrogenase Deficiency

2003 ◽  
Vol 14 (4) ◽  
pp. 230-231 ◽  
Author(s):  
Amitabh Monga ◽  
Ravinder PS Makkar ◽  
Anju Arora ◽  
Surabhi Mukhopadhyay ◽  
Ajay K Gupta
Keyword(s):  
Viral Hepatitis ◽  
G6pd Deficiency ◽  
Hepatitis E Virus ◽  
Dehydrogenase Deficiency ◽  
Acute Viral Hepatitis ◽  
Hepatitis E ◽  
Severe Anemia ◽  
Northern India ◽  
Acute Hepatitis E ◽  
Glucose 6 Phosphate Dehydrogenase

Hepatitis E virus is one of the leading causes of acute viral hepatitis in India but usually manifests as a mild self-limiting illness. Viral hepatitis in the presence of glucose-6-phosphate dehydrogenase (G6PD) deficiency may be associated with complications such as severe anemia, hemolysis, renal failure, hepatic encephalopathy and even death. The incidence of G6PD deficiency in the general population of northern India is reported to be between 2.2% and 14%. Despite both hepatitis E infection and G6PD deficiency being common, their impact on patient illness has only recently been reported. The present study reports a case of severe hemolysis in a patient with G6PD deficiency and hepatitis E infection.

Role of hepatitis E virus antigen in confirming active viral replication in patients with acute viral hepatitis E infection

2013 ◽  
Vol 58 (2) ◽  
pp. 374-377 ◽  
Author(s):  
Ekta Gupta ◽  
Priyanka Pandey ◽  
Shivani Pandey ◽  
Manoj Kumar Sharma ◽  
Shiv Kumar Sarin
Keyword(s):  
Viral Replication ◽  
Viral Hepatitis ◽  
Hepatitis E Virus ◽  
Acute Viral Hepatitis ◽  
Hepatitis E ◽  
Virus Antigen ◽  
Active Viral Replication

Hepatitis E virus: Seroprevalence and associated factors in acute viral hepatitis during pregnancy

2017 ◽  
Vol 6 (3) ◽  
pp. 1
Author(s):  
Mitalkumari Gamit ◽  
Kanaiyalal Patel ◽  
Alpesh Rathod ◽  
Mamtakumari Shrivastav ◽  
Bhavika Patel ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Associated Factors ◽  
Hepatitis E Virus ◽  
Acute Viral Hepatitis ◽  
Hepatitis E

scholarly journals Acute viral Hepatitis E in antenatal women: a multicenter prospective study

2018 ◽  
Vol 7 (7) ◽  
pp. 2655
Author(s):  
Kaveri Shaw Patel ◽  
Manish Tiwari ◽  
Sudha Choubey ◽  
Anivesh Jain ◽  
Lovely Jain ◽  
...  
Keyword(s):  
Prospective Study ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Gestational Age ◽  
Acute Viral Hepatitis ◽  
Descriptive Analysis ◽  
Hepatitis E ◽  
High Grade ◽  
Total Study Population

Background: Hepatitis E has poor prognosis in pregnancy and leads to 20-30% mortality in term cases. The Aim of the study was to observe the trend of maternal and perinatal outcome in acute viral hepatitis E.Methods: A prospective study conducted in two high risk obstetric center of Jabalpur district in January 2015 to December 2017. The inclusion criteria were all antenatal women diagnosed with acute viral Hepatitis E entering to the Intensive care unit of any gestational age who later delivered in the same center. Other than acute hepatitis E all acute hepatitis cases and women missed in follow up in delivery were excluded from the study. The data collected on demographic, clinical and biochemical variables in excel sheet and descriptive analysis done by SPSS system.Results: There were 72 antenatal women enrolled with mentioned criteria in study duration. Out of these only 67 were in follow up and alive till their delivery in the same set ups. Out of these 70.14% were Primigravida of median age 27 year. The mean gestational age at detection of hepatitis E was 30.3week. The maternal mortality observed was 17.9% (12/67) in the total study population. The high grade of mortality was significantly associated with high grade of disease. There were 19.4% (13/67) perinatal (mortality seen which included intrauterine (14.9%) and neonatal (4.4%).Conclusions: The severity of Hepatitis and high grade of hepatic encephalopathy following poor primary care in the beginning of disease results in poor perinatal and maternal outcome.

scholarly journals Acute viral hepatitis morbidity and mortality associated with hepatitis E virus infection: Uzbekistan surveillance data

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Makhmudkhan B Sharapov ◽  
Michael O Favorov ◽  
Tatiana L Yashina ◽  
Matthew S Brown ◽  
Gennady G Onischenko ◽  
...  
Keyword(s):  
Virus Infection ◽  
Viral Hepatitis ◽  
Hepatitis E Virus ◽  
Acute Viral Hepatitis ◽  
Hepatitis E ◽  
Surveillance Data ◽  
Morbidity And Mortality

scholarly journals Hepatitis E virus is the leading cause of acute viral hepatitis in Lothian, Scotland

2016 ◽  
Vol 10 ◽  
pp. 6-12 ◽  
Author(s):  
I. Kokki ◽  
D. Smith ◽  
P. Simmonds ◽  
S. Ramalingam ◽  
L. Wellington ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis E Virus ◽  
Acute Viral Hepatitis ◽  
Hepatitis E
Sign in / Sign up

Export Citation Format

Share Document