The Role of Justicia Adhatoda as prophylaxis for COVID-19 – Analysis based on docking study

2021 ◽  
Vol 21 ◽  
Author(s):  
Pugazhenthan Thangaraju ◽  
Sree Sudha TY ◽  
Praveen Kumar Pasala ◽  
Sri Hari TY ◽  
Sajitha Venkatesan ◽  
...  
Keyword(s):  
Docking Study ◽  
Symptomatic Management ◽  
Herbal Compound ◽  
Screening Study ◽  
Justicia Adhatoda ◽  
Respiratory Conditions ◽  
3Cl Protease ◽  
Affinity Score ◽  
Virus Proteins

: Coronavirus cause severe harm to the health of both humans as well as animals, creating a major global health problem affecting millions of populations. Considering situational emergency of identifying novel targeted therapy, we have chosen herbal compound Adathoda justice/ vasica which is high potent olden vital compound having key role in various respiratory conditions with multiple beneficial uses. Adathoda is promoted and supported by the Ministry of AYUSH for symptomatic management of respiratory ailments in case of COVID 19. In this study, we focused Adathoda primary active alkaloid vasicine efficacy against coronavirus infectious symptoms, evaluated by in Silico screening studies on virus proteins ACE 2 Receptor, 3CL protease and Spike protein SARS HR1 motif using PyRx tool and AutoDoc 1.5.6. Based on PyRx results, Vasicine with ACE 2 Receptor shown higher docking affinity score -7.1 K/cal respectively when compared to other virus proteins. AutoDoc 1.5.6 screening study report showed that vasicine promotes good inhibitory constant 486.54 mM on 3CL protease more than others. Results reveal that the vasicine could be a potential target for the treatment of COVID 19. This study adds strong evidence to the claim by the advisory released by AYUSH. Based on the results with available literature Adathoda could be a drug helpful in relieving symptoms in non COVID cases those who were quarantined or in lockdown pace thereby reducing pandemic panic and in confirmed asymptomatic or mild cases. For usage in moderate to severe cases this could be an add on therapy with existing modern medical therapy.

scholarly journals Design, synthesis, molecular docking, and in vitro α-glucosidase inhibitory activities of novel 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines against yeast and rat α-glucosidase

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fariba Peytam ◽  
Ghazaleh Takalloobanafshi ◽  
Toktam Saadattalab ◽  
Maryam Norouzbahari ◽  
Zahra Emamgholipour ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Study ◽  
Rat Small Intestine ◽  
Molecular Docking Study ◽  
Design Synthesis ◽  
Mild Conditions ◽  
Glucosidase Inhibitors ◽  
Inhibitory Activities

AbstractIn an attempt to find novel, potent α-glucosidase inhibitors, a library of poly-substituted 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines 3a–ag have been synthesized through heating a mixture of 2-aminobenzimidazoles 1 and α-azidochalcone 2 under the mild conditions. This efficient, facile protocol has been resulted into the desirable compounds with a wide substrate scope in good to excellent yields. Afterwards, their inhibitory activities against yeast α-glucosidase enzyme were investigated. Showing IC50 values ranging from 16.4 ± 0.36 µM to 297.0 ± 1.2 µM confirmed their excellent potency to inhibit α-glucosidase which encouraged us to perform further studies on α-glucosidase enzymes obtained from rat as a mammal source. Among various synthesized 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines, compound 3k exhibited the highest potency against both Saccharomyces cerevisiae α-glucosidase (IC50 = 16.4 ± 0.36 μM) and rat small intestine α-glucosidase (IC50 = 45.0 ± 8.2 μM). Moreover, the role of amine moiety on the observed activity was studied through substituting with chlorine and hydrogen resulted into a considerable deterioration on the inhibitory activity. Kinetic study and molecular docking study have confirmed the in-vitro results.

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

Hematology ◽  
2013 ◽  
Vol 2013 (1) ◽  
pp. 362-369 ◽  
Author(s):  
Deepa Manwani ◽  
Paul S. Frenette
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Targeted Therapies ◽  
Therapeutic Intervention ◽  
Fetal Hemoglobin ◽  
Cell Disease ◽  
The Past ◽  
Symptomatic Management

Abstract Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell disease. Symptomatic management and prevention of these events using the fetal hemoglobin–reactivating agent hydroxyurea are currently the mainstay of treatment. Discoveries over the past 2 decades have highlighted the important contributions of various cellular and soluble participants in the vaso-occlusive cascade. The role of these elements and the opportunities for therapeutic intervention are summarized in this review.

Role of ultrasonography in assessment of painful ankle

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed Amin Nassef ◽  
Shaimaa El Metwaly El Diasty ◽  
Marina Sameh Lamei
Keyword(s):  
Ankle Joint ◽  
Joint Pain ◽  
Pathological Condition ◽  
Ankle Injuries ◽  
Ankle Pain ◽  
Cross Sectional ◽  
Screening Study ◽  
Underlying Causes ◽  
Post Traumatic

Abstract Background Ankle disorders are a relatively common pathological condition, and ankle injuries account for approximately 14% of sports-related orthopedic emergency visits. Various imaging modalities can be used to make a diagnosis in cases of ankle pain; however, ultrasound (US) has several benefits for the evaluation of ankle pain, especially in the tendons, ligaments, and nerves of the ankle. Aim of the work to assess the role of high resolution US as a valuable tool in the depiction of causes of ankle joint pain. Patient & methods our study is a cross sectional descriptive screening study including 25 patients with ankle joint pain (acute or chronic), post traumatic or not with no age or sex predilection. Results The study included 15 (60%) males and 10 (40%) females. Their age ranged from 10 to 60 years with a mean age of 33.84±13.31years. Chronic ankle pain was the most common presenting symptom in 15 patients (60%) whereas 10 (40%) patients presented with acute ankle pain after trauma. The posterior ankle compartment was the most common affected compartment (24%) of cases. About 7 cases (28%) were presented by ankle swelling with or without pain. Conclusion In conclusion, MSK US is useful in detecting the underlying causes of ankle pain and still it has the potential to offer more valuable data if it is well mastered by the sonographers.

Oxford Handbook of Respiratory Nursing

2021 ◽  
Author(s):  
Terry Robinson ◽  
Jane Scullion
Keyword(s):  
Full Range ◽  
Tertiary Care ◽  
Special Focus ◽  
Nursing Management ◽  
Care Needs ◽  
Mortality And Morbidity ◽  
Psychosocial Concerns ◽  
Significant Burden ◽  
Respiratory Conditions

Respiratory disease is one of the leading causes of both mortality and morbidity, causing a significant burden on healthcare resources, the economy, and on individual patients and their carers. Respiratory conditions are managed in many different settings, from home and residential care through the full range of primary to tertiary care. The multifaceted nature of both diseases affecting respiration and the care options is comprehensively covered in this second edition of the Oxford Handbook of Respiratory Nursing. Offering a systematic description of the main respiratory diseases found in adults, the Handbook covers the assessment, diagnosis, and nursing management of each condition. With a special focus on the role of the multidisciplinary team in meeting the multiple care needs of respiratory patients, the Handbook covers both physical and psychosocial concerns, and both pharmacological and non-pharmacological therapies.

Octreotide for Malignant Bowel Obstruction (DRAFT)

2018 ◽  
Author(s):  
Shalini Dalal
Keyword(s):  
Prospective Study ◽  
Bowel Obstruction ◽  
Clinical Case ◽  
Malignant Bowel Obstruction ◽  
Advanced Cancer Patients ◽  
Symptomatic Management ◽  
A Prospective Study ◽  
Study Intervention

This chapter describes a prospective study published in 2002 evaluating the role of octreotide in the symptomatic management of advanced cancer patients with bowel obstruction that cannot be treated surgically. The chapter describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case. Topics covered include octreotide, bowel obstruction, vomiting, and abdominal distention.

Role of Pore Volume and Surface Area of Cu‐BTC and MIL‐100 (Fe) Metal‐Organic Frameworks on the Loading of Rifampicin: Collective Experimental and Docking Study

2020 ◽  
Vol 5 (40) ◽  
pp. 12398-12406
Author(s):  
Jagannath Panda ◽  
Satya Narayan Sahu ◽  
Rasmirekha Pati ◽  
Prasanna Kumar Panda ◽  
Bankim Chandra Tripathy ◽  
...  
Keyword(s):  
Surface Area ◽  
Pore Volume ◽  
Metal Organic Frameworks ◽  
Docking Study ◽  
Metal Organic

scholarly journals Varicella-Zoster Virus Proteins in Skin Lesions: Implications for a Novel Role of ORF29p in Chickenpox

2000 ◽  
Vol 74 (4) ◽  
pp. 2005-2010 ◽  
Author(s):  
Paula W. Annunziato ◽  
Octavian Lungu ◽  
Christos Panagiotidis ◽  
Jing H. Zhang ◽  
David N. Silvers ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Skin Biopsy ◽  
Varicella Zoster Virus ◽  
Nuclear Protein ◽  
Cell Types ◽  
Skin Lesions ◽  
Varicella Zoster ◽  
Human Neurons ◽  
Virus Proteins

ABSTRACT Skin biopsy samples from varicella-zoster virus (VZV)-infected patients examined by immunohistochemistry demonstrated VZV replication in nonepithelial cell types. ORF29p, a nonstructural nuclear protein, was found in nerves of two of six patients with chickenpox. In tissue culture, ORF29p was secreted by VZV-infected fibroblasts. Extracellular ORF29p can be taken up through endocytosis by human neurons, implying a novel role for this protein in pathogenesis.

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