Role of Nitric Oxide Signaling Pathways in Brain Injuries

2010 ◽  
Vol 4 (3) ◽  
pp. 250-261
Author(s):  
Maria Aurelia Zorrilla-Zubilete ◽  
Damian Gustavo Maur ◽  
Maria Laura Palumbo ◽  
Ana Maria Genaro
2010 ◽  
Vol 4 (3) ◽  
pp. 250-261
Author(s):  
Maria Aurelia Zorrilla-Zubilete ◽  
Damian Gustavo Maur ◽  
Maria Laura Palumbo ◽  
Ana Maria Genaro

2018 ◽  
Vol 16 (2) ◽  
pp. 194-199
Author(s):  
Wioletta Ratajczak-Wrona ◽  
Ewa Jablonska

Background: Polymorphonuclear neutrophils (PMNs) play a crucial role in the innate immune system’s response to microbial pathogens through the release of reactive nitrogen species, including Nitric Oxide (NO). </P><P> Methods: In neutrophils, NO is produced by the inducible Nitric Oxide Synthase (iNOS), which is regulated by various signaling pathways and transcription factors. N-nitrosodimethylamine (NDMA), a potential human carcinogen, affects immune cells. NDMA plays a major part in the growing incidence of cancers. Thanks to the increasing knowledge on the toxicological role of NDMA, the environmental factors that condition the exposure to this compound, especially its precursors- nitrates arouse wide concern. Results: In this article, we present a detailed summary of the molecular mechanisms of NDMA’s effect on the iNOS-dependent NO production in human neutrophils. Conclusion: This research contributes to a more complete understanding of the mechanisms that explain the changes that occur during nonspecific cellular responses to NDMA toxicity.


Physiology ◽  
2013 ◽  
Vol 28 (4) ◽  
pp. 216-224 ◽  
Author(s):  
John W. Calvert ◽  
David J. Lefer

Exercise promotes cardioprotection in both humans and animals not only by reducing risk factors associated with cardiovascular disease but by reducing myocardial infarction and improving survival following ischemia. This article will define the role that nitric oxide and β-adrenergic receptors play in mediating the cardioprotective effects of exercise in the setting of ischemia-reperfusion injury.


2018 ◽  
Vol 234 (7) ◽  
pp. 11411-11423 ◽  
Author(s):  
Mohammad Khabbaz Shirazi ◽  
Asaad Azarnezhad ◽  
Mohammad Foad Abazari ◽  
Mansour Poorebrahim ◽  
Pegah Ghoraeian ◽  
...  

2010 ◽  
Vol 5 (6) ◽  
pp. 698-701 ◽  
Author(s):  
María Cecilia Terrile ◽  
Claudia Virginia Tonón ◽  
María José Iglesias ◽  
Lorenzo Lamattina ◽  
Claudia Anahí Casalongué

2008 ◽  
Vol 146 (4) ◽  
pp. 391-395 ◽  
Author(s):  
E. B. Manukhina ◽  
M. G. Pshennikova ◽  
A. V. Goryacheva ◽  
I. P. Khomenko ◽  
S. Yu. Mashina ◽  
...  

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