Novel Diagnostics R&D for Public Health and Personalized Medicine in Taiwan: Current State, Challenges and Opportunities

We review evidence for links between personality traits and longevity. We provide an overview of personality for health scientists, using the primary organizing framework used in the study of personality and longevity. We then review data on various aspects of personality linked to longevity. In general, there is good evidence that higher level of conscientiousness and lower levels of hostility and Type D or “distressed” personality are associated with greater longevity. Limited evidence suggests that extraversion, openness, perceived control, and low levels of emotional suppression may be associated with longer lifespan. Findings regarding neuroticism are mixed, supporting the notion that many component(s) of neuroticism detract from life expectancy, but some components at some levels may be healthy or protective. Overall, evidence suggests various personality traits are significant predictors of longevity and points to several promising directions for further study. We conclude by discussing the implications of these links for epidemiologic research and personalized medicine and lay out a translational research agenda for integrating the psychology of individual differences into public health and medicine.

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Molecular diagnostics and personalized medicine in oncology: Challenges and opportunities

Journal of Cellular Biochemistry ◽

10.1002/jcb.24401 ◽

2013 ◽

Vol 114 (3) ◽

pp. 514-524 ◽

Cited By ~ 38

Author(s):

Nicola Normanno ◽

Anna Maria Rachiglio ◽

Cristin Roma ◽

Francesca Fenizia ◽

Claudia Esposito ◽

...

Keyword(s):

Personalized Medicine ◽

Molecular Diagnostics ◽

Challenges And Opportunities ◽

And Personalized Medicine

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Antithrombotic Therapy in Patients with Acute Coronary Syndromes: Biological Markers and Personalized Medicine

Conference Papers in Medicine ◽

10.1155/2013/764619 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4

Author(s):

Peter W. Radke

Keyword(s):

Personalized Medicine ◽

Receptor Binding ◽

Medical Practice ◽

Biological Markers ◽

Gold Standard ◽

Antithrombotic Therapy ◽

Acute Coronary Syndromes ◽

Challenges And Opportunities ◽

Coronary Syndromes ◽

And Personalized Medicine

Antithrombin and antiplatelet therapies have been in the focus of pharmacological developments over recent years with an increasing number of anticoagulants and antiplatelets becoming available. While these drugs share common pharmacological characteristics (i.e., antiplatelet drugs binding to the P2Y12 receptor), they also differ substantially regarding metabolism, type of receptor binding, clinical end points that have been reduced as compared to the current gold standard, and, consequently, the spectrum of indication. These differences pose the need and, above that, great chances for therapy personalization. Understanding the challenges and opportunities that arise from the use of biological markers in guiding antiplatelet therapy is mandatory to provide best medical practice for patients with acute coronary syndromes.

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Current state of salivaomics and metabolomic profiling as novel diagnostics for biomarker research and applications in oral cancer and personalized medicine

Tropical Journal of Medical Research ◽

10.4103/tjmr.tjmr_28_16 ◽

2017 ◽

Vol 20 (2) ◽

pp. 127

Author(s):

Simi Thankappan ◽

N Sherin

Keyword(s):

Oral Cancer ◽

Personalized Medicine ◽

Metabolomic Profiling ◽

Current State ◽

Biomarker Research ◽

And Personalized Medicine

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Personalized Medicine and Genomics: Challenges and Opportunities in Assessing Effectiveness, Cost-Effectiveness, and Future Research Priorities

Medical Decision Making ◽

10.1177/0272989x09347014 ◽

2010 ◽

Vol 30 (3) ◽

pp. 328-340 ◽

Cited By ~ 74

Author(s):

Rena Conti ◽

David L. Veenstra ◽

Katrina Armstrong ◽

Lawrence J. Lesko ◽

Scott D. Grosse

Keyword(s):

Decision Making ◽

Personalized Medicine ◽

Research Priorities ◽

Molecular Medicine ◽

Medical Decision ◽

Future Research ◽

Targeted Interventions ◽

Current State ◽

Challenges And Opportunities ◽

Future Work

Personalized medicine is health care that tailors interventions to individual variation in risk and treatment response. Although medicine has long strived to achieve this goal, advances in genomics promise to facilitate this process. Relevant to present-day practice is the use of genomic information to classify individuals according to disease susceptibility or expected responsiveness to a pharmacologic treatment and to provide targeted interventions. A symposium at the annual meeting of the Society for Medical Decision Making on 23 October 2007 highlighted the challenges and opportunities posed in translating advances in molecular medicine into clinical practice. A panel of US experts in medical practice, regulatory policy, technology assessment, and the financing and organization of medical innovation was asked to discuss the current state of practice and research on personalized medicine as it relates to their own field. This article reports on the issues raised, discusses potential approaches to meet these challenges, and proposes directions for future work. The case of genetic testing to inform dosing with warfarin, an anticoagulant, is used to illustrate differing perspectives on evidence and decision making for personalized medicine.

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