A Review of Basics and Potential of Liquid Crystalline Nanoparticles as Drug Delivery Systems

2021 ◽  
Vol 11 ◽  
Author(s):  
Mangesh Pradeep Kulkarni ◽  
Poluri Sesha Sai Kiran ◽  
Kamaldeep Singh ◽  
Kamal Dua ◽  
Sagar Tanwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liquid Crystals ◽  
Liquid Crystalline ◽  
Structural Alignment ◽  
Physical Parameters ◽  
Stable Form ◽  
Theranostic Agent ◽  
Self Assembling ◽  
Liquid Crystalline Nanoparticles ◽  
Made In

Aim: For procuring the stable form of drug delivery, tremendous efforts have been made in developing new drug delivery vectors. One such approach that meets the desired stability standards is Liquid Crystalline Nanoparticles (LCNs). Background: The liquid crystals are the intermediate forms of solid and liquid materials, which hold high tolerance to bear the influences of physical parameters. The liquid crystals are employed in nanotechnology to find the best way to produce the intended action of customized targeting drug delivery. The structural alignment is another critical aspect to consider, as these can accommodate wholesome drug amounts. Methods: From the studies, it has been evident that distinct characteristics like the simplicity in structure, self-assembling properties, feasibility of production, efficacy in delivery with low toxic values, have addressed the excellency of LCNs. Conclusion: The current review focusses on key areas regarding the nature of liquid crystal, diverse forms, technologies used to transform them into the desired nanoparticles, and their applications as drug delivery carriers as well as theranostic agent.

Nanoparticles in Liquid Crystals and Liquid Crystalline Nanoparticles

2011 ◽  
pp. 331-393 ◽  
Author(s):  
Oana Stamatoiu ◽  
Javad Mirzaei ◽  
Xiang Feng ◽  
Torsten Hegmann
Keyword(s):  
Liquid Crystals ◽  
Liquid Crystalline ◽  
Liquid Crystalline Nanoparticles

Current potential and challenges in the advances of liquid crystalline nanoparticles as drug delivery systems

2019 ◽  
Vol 24 (7) ◽  
pp. 1405-1412 ◽  
Author(s):  
Thiagarajan Madheswaran ◽  
Murugesh Kandasamy ◽  
Rajendran JC Bose ◽  
Vengadeshprabhu Karuppagounder
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Liquid Crystalline ◽  
Delivery Systems ◽  
Liquid Crystalline Nanoparticles ◽  
Current Potential

Interfacial properties of POPC/GDO liquid crystalline nanoparticles deposited on anionic and cationic silica surfaces

2016 ◽  
Vol 18 (38) ◽  
pp. 26630-26642 ◽  
Author(s):  
Debby P. Chang ◽  
Aleksandra P. Dabkowska ◽  
Richard A. Campbell ◽  
Maria Wadsäter ◽  
Justas Barauskas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liquid Crystalline ◽  
Interfacial Properties ◽  
High Potential ◽  
Silica Surfaces ◽  
Drug Molecules ◽  
Hydrophilic Drug ◽  
Liquid Crystalline Nanoparticles ◽  
Drug Delivery Applications

Reversed lipid liquid crystalline nanoparticles (LCNPs) of the cubic micellar (I2) phase have high potential in drug delivery applications due to their ability to encapsulate both hydrophobic and hydrophilic drug molecules.

scholarly journals NMR Spectroscopic Studies of Cation Dynamics in Symmetrically-Substituted Imidazolium-Based Ionic Liquid Crystals

2020 ◽  
Vol 21 (14) ◽  
pp. 5024
Author(s):  
Debashis Majhi ◽  
Andrei V. Komolkin ◽  
Sergey V. Dvinskikh
Keyword(s):  
Ionic Liquid ◽  
Liquid Crystals ◽  
Liquid Crystalline ◽  
Orientational Order ◽  
Soft Materials ◽  
Spectroscopic Studies ◽  
Single Chain ◽  
Self Assembling ◽  
Ionic Liquid Crystals ◽  
Cation Size

Ionic liquid crystals (ILCs) present a new class of non-molecular soft materials with a unique combination of high ionic conductivity and anisotropy of physicochemical properties. Symmetrically-substituted long-chain imidazolium-based mesogenic ionic liquids exhibiting a smectic liquid crystalline phase were investigated by solid state NMR spectroscopy and computational methods. The aim of the study was to reveal the correlation between cation size and structure, local dynamics, and orientational order in the layered mesophase. The obtained experimental data are consistent with the model of a rod-shaped cation with the two chains aligned in opposite directions outward from the imidazolium core. The alignment of the core plane to the phase director and the restricted conformations of the chain segments were determined and compared to those in single-chain counterparts. The orientational order parameter S~0.5–0.6 of double-chain ionic liquid crystals is higher than that of corresponding single-chain analogues. This is compatible with the enhanced contribution of van der Waals forces to the stabilization of smectic layers. Increased orientational order for the material with Br− counterions, which exhibit a smaller ionic radius and higher ability to form hydrogen bonds as compared to that of BF4−, also indicated a non-negligible influence of electrostatic and hydrogen bonding interactions. The enhanced rod-shape character and higher orientational order of symmetrically-substituted ILCs can offer additional opportunities in the design of self-assembling non-molecular materials.

Liquid Crystalline System

2017 ◽  
pp. 190-216
Author(s):  
Nayan Ashok Gujarathi ◽  
Bhushan Rajendra Rane ◽  
Raj K. Keservani
Keyword(s):  
Drug Delivery ◽  
Liquid Crystal ◽  
Liquid Crystals ◽  
Liquid Crystalline ◽  
Stable Phase ◽  
Science And Engineering ◽  
Liquid Crystalline Phases ◽  
Molecular Scale ◽  
Crystalline System ◽  
Liquid Crystalline System

Liquid crystalline system is a thermodynamically stable phase which is characterized by anisotropy. Liquid Crystals (LCs) are also termed as mesophase as they exhibit isotropic properties and liquid like behavior under some conditions (alter in temperature and concentration). Liquid crystals are influenced by number of parameters includes concentration, temperature, pH, and presence of salt. Liquid crystals are divided on the basis of shape of the molecules into two groups one is calmitic and other is discotic. A range of liquid crystalline phase (called mesophases) can be categorized by their sort of arrangement. The alignment of fragments in liquid crystalline phases is extensive on the molecular scale. Liquid crystal technology has a most important influence on several areas of pharmacy science and engineering, as well as device technology. As a novel type of drug delivery system, liquid crystals are explored and examined, definitely achieve mounting significance in industrial and scientific purposes.

Physicochemical and Drug Delivery Aspects of Lipid-Based Liquid Crystalline Nanoparticles: A Case Study of Intravenously Administered Propofol

2006 ◽  
Vol 6 (9) ◽  
pp. 3017-3024 ◽  
Author(s):  
Markus Johnsson ◽  
Justas Barauskas ◽  
Andreas Norlin ◽  
Fredrik Tiberg
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Drug Loading ◽  
Drug Substances ◽  
Physicochemical Features ◽  
Liquid Crystalline Nanoparticles ◽  
Effect Duration

Liquid crystalline nanoparticles (LCNP) formed through lipid self-assembly have a range of attractive properties as in vivo drug delivery carriers. In particular they offer: a wide solubilization spectrum, and consequently high drug payloads; effective encapsulation; stabilization and protection of sensitive drug substances. Here we present basic physicochemical features of non-lamellar LCNP systems with a focus on intravenous drug applications. This is exemplified by the formulation properties and in vivo behavior using the drug substance propofol; a well-known anesthetic agent currently used in clinical practice in the form of a stable emulsion. In order to appraise the drug delivery features of the LCNP system the current study was carried out with a marketed propofol emulsion product as reference. In this comparison the propofol-LCNP formulation shows several useful features including: higher drug-loading capacity, lower fat-load, excellent stability, modified pharmacokinetics, and an indication of increased effect duration.

Bioimaging Applications of Non-Lamellar Liquid Crystalline Nanoparticles

2021 ◽  
Vol 21 (5) ◽  
pp. 2742-2759
Author(s):  
Sergio Murgia ◽  
Stefania Biffi ◽  
Marco Fornasier ◽  
Vito Lippolis ◽  
Giacomo Picci ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Liquid Crystalline ◽  
Colloidal Nanoparticles ◽  
Self Assembling ◽  
Complex Architectures ◽  
Imaging Probes ◽  
Bicontinuous Cubic ◽  
Liquid Crystalline Nanoparticles

Self-assembling processes of amphiphilic lipids in water give rise to complex architectures known as lyotropic liquid crystalline (LLC) phases. Particularly, bicontinuous cubic and hexagonal LLC phases can be dispersed in water forming colloidal nanoparticles respectively known as cubosomes and hexosomes. These non-lamellar LLC dispersions are of particular interest for pharmaceutical and biomedical applications as they are potentially non-toxic, chemically stable, and biocompatible, also allowing encapsulation of large amounts of drugs. Furthermore, conjugation of specific moieties enables their targeting, increasing therapeutic efficacies and reducing side effects by avoiding exposure of healthy tissues. In addition, as they can be easy loaded or functionalized with both hydrophobic and hydrophilic imaging probes, cubosomes and hexosomes can be used for the engineering of multifunctional/theranostic nanoplatforms. This review outlines recent advances in the applications of cubosomes and hexosomes for in vitro and in vivo bioimaging.

scholarly journals Cubic and Hexagonal Liquid Crystals as Drug Delivery Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Yulin Chen ◽  
Ping Ma ◽  
Shuangying Gui
Keyword(s):  
Drug Delivery ◽  
Liquid Crystals ◽  
Drug Delivery Systems ◽  
Liquid Crystalline ◽  
Hexagonal Phase ◽  
Delivery Systems ◽  
Lyotropic Liquid Crystals ◽  
Cubic Phase ◽  
Sustained Drug Release ◽  
Wide Range

Lipids have been widely used as main constituents in various drug delivery systems, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-based lyotropic liquid crystals. Among them, lipid-based lyotropic liquid crystals have highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix. The intricate nanostructures of the cubic phase and hexagonal phase have been shown to provide diffusion controlled release of active pharmaceutical ingredients with a wide range of molecular weights and polarities. In addition, the biodegradable and biocompatible nature of lipids demonstrates the minimum toxicity and thus they are used for various routes of administration. Therefore, the research on lipid-based lyotropic liquid crystalline phases has attracted a lot of attention in recent years. This review will provide an overview of the lipids used to prepare cubic phase and hexagonal phase at physiological temperature, as well as the influencing factors on the phase transition of liquid crystals. In particular, the most current research progresses on cubic and hexagonal phases as drug delivery systems will be discussed.

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