A Dig Deep to Scout the Pharmacological and Clinical facet of Garlic (Alium Cepa)

2021 ◽  
Vol 07 ◽  
Author(s):  
M. U. Khan ◽  
Habibullah Khalilullah ◽  
Faizul Azam ◽  
Masood Alam Khan ◽  
Arif Khan ◽  
...  
Keyword(s):  
Allium Sativum ◽  
Cultivated Plants ◽  
Systematic Research ◽  
Allergic Reactions ◽  
Microbial Infections ◽  
History Of ◽  
Anti Oxidant ◽  
Ancient Times ◽  
Positive Results ◽  
Culinary Herb

: Garlic, Allium sativum L. is a culinary herb that has been employed medicinally since ancient times. Garlic has been regarded as the oldest of all cultivated plants. A variety of experimental as well as human studies have been accounted that garlic is used in preventing initiation and evolution of several ailments such as hypertension, atherosclerosis, diabetes mellitus, cancer, microbial infections, arthritis, thrombosis, Alzheimer and act as anti-oxidant. The preclinical toxicity study gives an impression that garlic is safe, although allergic reactions may occur. Recently there has been systematic research regarding garlic, and positive results have been attained in healing many diseases, for centuries many countries of different civilization and continents have protecting their populations and healing themselves by using garlic. Therefore, there is an augmented necessity of investigation on the history of garlic for the sake of strengthening the ability of physicians and pharmacist to reply to the challenges arising in the provision of specialized facilities to serve mankind. The present review provides morphological, pharmacological and toxicological insight regarding garlic. Advancement in studies are required to explicate the therapeutic mode of action of the garlic along with its potency, effectiveness and clinical wellbeing in management of different ailments.

ITI with high-dose FIX and combined immunosuppressive therapy in a patient with severe haemophilia B and inhibitor

2009 ◽  
Vol 29 (02) ◽  
pp. 155-157 ◽  
Author(s):  
H. Hauch ◽  
J. Rischewski ◽  
U. Kordes ◽  
J. Schneppenheim ◽  
R. Schneppenheim ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Immunosuppressive Agents ◽  
Tolerance Induction ◽  
Intravenous Immunoglobulins ◽  
Factor Ix ◽  
High Dose ◽  
Allergic Reactions ◽  
Success Rates ◽  
Serious Infections ◽  
History Of

SummaryInhibitor development is a rare but serious event in hemophilia B patients. Management is hampered by the frequent occurrence of allergic reactions to factor IX, low success rates of current inhibitor elimination protocols and the risk of development of nephrotic syndrome. Single cases of immune tolerance induction (ITI) including immunosuppressive agents like mycophenolat mofetil (MMF) or rituximab have been reported. We present a case of successful inhibitor elimination with a combined immune-modulating therapy and high-dose factor IX (FIX). This boy had developed a FIX inhibitor at the age of 5 years and had a history of allergic reactions to FIX and to FEIBA→. Under on-demand treatment with recombinant activated FVII the inhibitor became undetectable but the boy suffered from multiple joint and muscle bleeds. At the age of 11.5 years ITI was attempted with a combination of rituximab, MMF, dexamethasone, intravenous immunoglobulins and high-dose FIX. The inhibitor did not reappear and FIX half-life normalized. No allergic reaction, no signs of nephrotic syndrome and no serious infections were observed.

History of thyroid surgery

2020 ◽  
Vol 99 (11) ◽  
Keyword(s):  
Surgical Technique ◽  
20Th Century ◽  
Thyroid Surgery ◽  
History Of ◽  
Ancient Times

The authors present an outline of the development of thyroid surgery from the ancient times to the beginning of the 20th century, when the definitive surgical technique have been developed and the physiologic and pathopfysiologic consequences of thyroid resections have been described. The key representatives, as well as the contribution of the most influential czech surgeons are mentioned.

HAJJ AND THE RULERS OF

2019 ◽  
Vol 18 (2) ◽  
pp. 24-37
Author(s):  
D.X. Sangirova ◽  
Keyword(s):  
Middle Ages ◽  
Sacred Place ◽  
History Of ◽  
Ancient Times ◽  
The Middle Ages

Revered since ancient times, the concept of "sacred place" in the middle ages rose to a new level. The article analyzes one of the important issues of this time - Hajj (pilgriamge associated with visiting Mecca and its surroundings at a certain time), which is one of pillars of Islam and history of rulers who went on pilgrimage

The diagnosis of early pneumoconiosis in dust-exposed workers: comparison of chest radiography and computed tomography

2021 ◽  
pp. 028418512110225
Author(s):  
Hideyuki Hayashi ◽  
Kazuto Ashizawa ◽  
Masashi Takahashi ◽  
Katsuya Kato ◽  
Hiroaki Arakawa ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Chest Radiography ◽  
Pulmonary Emphysema ◽  
Early Stage ◽  
Pathological Changes ◽  
Occupational History ◽  
Exposed Workers ◽  
History Of ◽  
Ct Data ◽  
Positive Results

Background Chest radiography (CR) is employed as the evaluation of pneumoconiosis; however, we sometimes encounter cases in which computed tomography (CT) is more effective in detecting subtle pathological changes or cases in which CR yields false-positive results. Purpose To compare CR to CT in the diagnosis of early-stage pneumoconiosis. Material and Methods CR and CT were performed for 132 workers with an occupational history of mining. We excluded 23 cases of arc-welder’s lung. Five readers who were experienced chest radiologists or pulmonologists independently graded the pulmonary small opacities on CR of the remaining 109 cases. We then excluded 37 cases in which the CT data were not sufficient for grading. CT images of the remaining 72 cases were graded by the five readers. We also assessed the degree of pulmonary emphysema in those cases. Results The grade of profusion on CR (CR score) of all five readers was identical in only 5 of 109 cases (4.6%). The CR score coincided with that on CT in 40 of 72 cases (56%). The CT score was higher than that on CR in 13 cases (18%). On the other hand, the CT score was lower than that on CR in 19 cases (26%). The incidence of pulmonary emphysema was significantly higher in patients whose CR score was higher than their CT score. Conclusion CT is more sensitive than CR in the evaluation of early-stage pneumoconiosis. In cases with emphysema, the CR score tends to be higher in comparison to that on CT.

scholarly journals Complicated cutaneous leishmaniasis caused by an imported case of Leishmania tropica in Japan: a case report

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Hiroyuki Kitano ◽  
Chizu Sanjoba ◽  
Yasuyuki Goto ◽  
Kazumasa Iwamoto ◽  
Hiroki Kitagawa ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Skin Lesions ◽  
Leishmania Tropica ◽  
Case Presentation ◽  
Imported Case ◽  
Imported Cases ◽  
History Of ◽  
Hematoxylin And Eosin ◽  
Polymerase Chain ◽  
Positive Results

Abstract Background Leishmaniasis is not endemic in Japan, and imported cases are rare. However, there are increasing concerns regarding imported cases of cutaneous leishmaniasis from endemic countries to Japan. This report describes a case of imported cutaneous leishmaniasis that was diagnosed and treated in Japan. Case presentation A 53-year-old Pakistani man presented with skin lesions on both malleoli of his right ankle and the dorsum of the left foot. The skin lesions manifested as erythematous nodules surrounding an ulcer in the center of the lesion. The lesions of the malleoli of his right ankle each measured 3 × 3 cm, and the lesion on the top of his left foot measured 5 × 4 cm. He had been living and working in Japan but had a history of a visit to Pakistan for about 2 months in 2018. The skin lesions were biopsied. Giemsa and hematoxylin and eosin staining of biopsy samples showed amastigotes of Leishmania in macrophages, and the presence of Leishmania was confirmed by skin tissue culture. Polymerase chain reaction using biopsy specimens identified Leishmania parasites, and DNA sequence analysis revealed that the species was Leishmania tropica. The patient was treated with intravenous liposomal amphotericin B for 6 days. The erythema disappeared, and the erythematous nodules resolved within 3 weeks. Conclusion This is the first report of imported cutaneous leishmaniasis caused by L. tropica from Pakistan, and it is interesting that all three testing modalities showed positive results in this case.

scholarly journals Spirituality and Conflict in Healthcare: The History of the Canadian Baptists and Medical Mission in Orissa, 1900–1970

Histories ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 69-84
Author(s):  
Tiasa Basu Roy
Keyword(s):  
Religious Identity ◽  
Well Being ◽  
Word Of God ◽  
Health Issues ◽  
Medical Mission ◽  
The People ◽  
Medical Facilities ◽  
History Of ◽  
Ganjam District ◽  
Positive Results

It was from the middle of the eighteenth century that discussions regarding the strategies taken up by the Protestant missionaries to propagate the Gospel generated the issue of healthcare and medical facilities among people in India. Medical mission, which hitherto was not considered, started to gain importance and reaped positive results in terms of curing individuals and its trustworthiness among tribes residing in the frontier regions. However, this developed a separatist religious identity among the population, which apparently did not appear lethal, but later culminated in the fragmentation and impeachment of solidarity among the adivais (tribal) and vengeance from the Hindu population. This article will show how the Canadian Baptist Mission, with its primary aim of spreading the Kingdom of God among the tribal Savaras in the Ganjam district of Orissa, undertook measures for serving health issues and provided medical facilities to both the caste Oriyas and the tribal Savaras. Although medical activities oriented towards philanthropy and physical well-being, medical mission was not limited to healing illness and caring for all, but also extended to spreading the word of God and influencing the people to embrace Christianity as well, which invited political troubles into the region.

scholarly journals The Carol about the Pagan Rite of Sacrifice of a Goat and Its Interpretation in Russian Scholarship of the 19th to 20th Centuries

Religions ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 366
Author(s):  
Andrey Toporkov
Keyword(s):  
Historical Document ◽  
Authentic Texts ◽  
History Of ◽  
Ancient Times

In publications of Russian folklore, along with authentic texts there are a number of literary stylizations based on folklore. The article traces the history of one such pseudo-folkloric text—a carol which was first published by Ivan Petrovich Sakharov (1807 to 1863) in 1837. It has been established that this carol is a montage of two texts: the first is a carol, printed in 1817 by I.E. Sreznevsky in the Ukrainian Bulletin, and the second is a song included in the Tale of Brother Ivanushka and his Sister Alyonushka (SUS 450). Such contamination is unique and is found only in this one text, which was later reprinted many times. Taking into account Sakharov’s reputation as a falsifier of folklore, there is no reason to doubt that it was he who composed this carol; such contamination of works belonging to different folkloric genres is also characteristic of other of Sakharov’s publications. The carol that Sakharov published attracted the particular interest of researchers of Slavic mythology due to the fact that it described how an old man was going to sacrifice a goat. Several generations of historians saw in this pseudo-folkloric text a description of a ritual that pagan Slavs performed in ancient times. Considering the carol as an historical document, researchers of mythology built their interpretations based on the supposed time of its appearance, the nature of its genre, plot, and individual details. Thus, Sakharov’s pseudo-folkloric creation found an eager audience among scholars, and it stimulated their imagination in picturing the life of pagan Rus’.

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