SeDeM Expert System, An Innovative Tool for Developing Directly Compressible Tablets: A Review
Background: SeDeM (Sediment Delivery Model) expert system is a preformulation tool employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameter and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15 parameter derived diagram that can be used as a research tool for reducing the product development time. Best possible excipients for a specified pharmaceutical active ingredient could be screened for direct compression suitability. Objective: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained release formulations and development of tablets of taste masked drugs. Conclusion: In the present review paper development and applications of SeDeM and SeDeM-ODT systems have been discussed in detail.