New SeDeM-ODT expert system: an expert system for formulation of orodispersible tablets obtained by direct compression

2013 ◽  
pp. 137-154 ◽  
Author(s):  
Johnny Edward Aguilar ◽  
Encarna García Montoya ◽  
Pilar Pérez Lozano ◽  
Josep M. Suñe Negre ◽  
Montserrat Miñarro Carmona ◽  
...  
Keyword(s):  
Expert System ◽  
Direct Compression ◽  
Orodispersible Tablets

SeDeM Expert System, An Innovative Tool for Developing Directly Compressible Tablets: A Review

2020 ◽  
Vol 12 ◽  
Author(s):  
Inderbir Singh ◽  
Ajay Kumar Thakur ◽  
Rajni Bala ◽  
Reecha Madan
Keyword(s):  
Expert System ◽  
Sustained Release ◽  
Active Ingredient ◽  
Development Time ◽  
Review Paper ◽  
Direct Compression ◽  
Sediment Delivery ◽  
Delivery Model ◽  
Orodispersible Tablets ◽  
Innovative Tool

Background: SeDeM (Sediment Delivery Model) expert system is a preformulation tool employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameter and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15 parameter derived diagram that can be used as a research tool for reducing the product development time. Best possible excipients for a specified pharmaceutical active ingredient could be screened for direct compression suitability. Objective: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained release formulations and development of tablets of taste masked drugs. Conclusion: In the present review paper development and applications of SeDeM and SeDeM-ODT systems have been discussed in detail.

scholarly journals Preparation and evaluation of diclofenac sodium orally disintegrating tablets

2016 ◽  
Vol 27 (1) ◽  
pp. 58-61
Author(s):  
Valeriu Iancu ◽  
Florentina Roncea ◽  
Radu George Cazacincu ◽  
Dumitru Lupuleasa
Keyword(s):  
Diclofenac Sodium ◽  
Magnesium Stearate ◽  
Dosage Forms ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Orodispersible Tablets ◽  
Orally Disintegrating Tablets ◽  
Wetting Time ◽  
Preparation And Evaluation

Abstract Orally disintegrating tablets (ODTs) are dosage forms which disintegrate in mouth within seconds without need of water. This type of quality in dosage form can be attained by addition of different varieties of excipients. Pharmaburst™ 500 is a co-processed excipient system which allows rapid disintegration and low adhesion to punches. The aim of the present study was to develop and evaluate 25 mg diclofenac sodium ODTs (orodispersible tablets) batches by direct compression method at different compression forces 10 kN (F1) and 20 kN (F2) and directly compressible excipients used in different ratio (Avicel PH 102, magnesium stearate and coprocessed excipient Pharmaburst™ 500, 70% and 80% w/w). The obtained batches were analyzed for appearance, tablet thickness, uniformity of weight, hardness, friability, disintegration time, and non-compendial methods (wetting time). Co-processed Pharmaburst™ 500 excipient 70% used for sodium diclofenac ODT obtaining determined good results for quality control tests evaluation.

scholarly journals Formulation and in vitro evaluation of orodispersible tablets of fexofenadine hydrochloride

2020 ◽  
Vol 19 (5) ◽  
pp. 919-925
Author(s):  
Durgaramani Sivadasan ◽  
Muhammad Hadi Sultan ◽  
Osama Madkhali ◽  
Shamama Javed ◽  
Aamena Jabeen
Keyword(s):  
Guar Gum ◽  
Polymer Concentration ◽  
In Vitro Release ◽  
Direct Compression ◽  
Compression Technique ◽  
Disintegration Time ◽  
Weight Fluctuation ◽  
Orodispersible Tablets ◽  
Croscarmellose Sodium

Purpose: To develop orodispersible tablets (ODTs) of fexofenadine hydrochloride using three different superdisintegrants in various ratios and to compare their disintegration properties.Methods: Direct compression technique was used for the preparation of ODTs. Mannitol and Avicel CE-15 (microcrystalline cellulose and guar gum) were used as direct compression diluents. The disintegration time of tablets using each polymer (superdisintegrant) was evaluated as well as othertablet properties including weight fluctuation, hardness, friability, wetting time and water absorption ratio.Results: Satisfactory values were obtained for all the evaluated parameters. As the polymer concentration increased, there was a decrease in disintegration time. A comparison of the three different polymers used revealed that CCM3 formulated with 12 % croscarmellose sodium and 14.66 % lactose had the least disintegration time of 32.33 ± 3.23 s. In vitro release studies showed that the maximum drug release of 94.38 ± 0.12 % in 25 min was obtained for ODT tablets containing croscarmellose sodium (CCM3).Conclusion: The orodispersible tablets had quick disintegrating property which was achieved using superdisintegrants. Thus, superdisintegrants improve the disintegration efficiency of orodispersible fexofenadine tablets at low concentrations, when compared to traditional disintegrants. Keywords: Croscarmellose sodium, Direct compression, Fexofenadine, Orodispersible tablets

scholarly journals FORMULATION AND EVALUATION OF TASTE MASKED ORODISPERSIBLE TABLETS OF AMLODIPINE BESYLATE BY DIRECT COMPRESSION

2013 ◽  
Vol 4 (7) ◽  
pp. 123-130 ◽  
Author(s):  
B Sree Giri Prasad ◽  
V R M Gupta ◽  
N Devanna ◽  
N Siva Subramanian ◽  
CH Naveen Kumar ◽  
...  
Keyword(s):  
Direct Compression ◽  
Amlodipine Besylate ◽  
Orodispersible Tablets

Formulation design and development to produce orodispersible tablets by direct compression

2007 ◽  
Vol 17 (3) ◽  
pp. 199-203 ◽  
Author(s):  
L. Segale ◽  
L. Maggi ◽  
E. Ochoa Machiste ◽  
S. Conti ◽  
U. Conte ◽  
...  
Keyword(s):  
Direct Compression ◽  
Design And Development ◽  
Formulation Design ◽  
Orodispersible Tablets

Formulation of Direct Compression Zidovudine Tablets to Correlate the SeDeM Diagram Expert System and the Rotary Press Simulator Styl’ONE Results

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Isaac Nofrerias ◽  
Anna Nardi ◽  
Marc Suñé-Pou ◽  
Josep M. Suñé-Negre ◽  
Encarna García-Montoya ◽  
...  
Keyword(s):  
Expert System ◽  
Direct Compression ◽  
Rotary Press

scholarly journals The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression

2014 ◽  
Vol 461 (1-2) ◽  
pp. 38-45 ◽  
Author(s):  
J. Saurí ◽  
D. Millán ◽  
J.M. Suñé-Negre ◽  
P. Pérez-Lozano ◽  
R. Sarrate ◽  
...  
Keyword(s):  
Expert System ◽  
Matrix Tablets ◽  
Direct Compression

scholarly journals FORMULATION AND EVALUATION OF TRAZODONE HYDROCHLORIDE ORODISPERSIBLE TABLETS

2018 ◽  
Vol 11 ◽  
Author(s):  
Akiladevi D
Keyword(s):  
Drug Release ◽  
Water Absorption ◽  
Content Uniformity ◽  
Direct Compression ◽  
In Vitro Drug Release ◽  
Orodispersible Tablets ◽  
Weight Variation ◽  
Study Results ◽  
Trazodone Hydrochloride

Objective: The objective of the existing research was to develop an oral disintegrating dissolving system as one of the taste masking orodispersible forms together of trazodone hydrochloride tablets using direct compression technique through the use of superdisintegrants together with FlowLac, StarLac, and sodium starch glycolate. Methods: The tablets were formulated using the direct compression approach. The drugs prepared have been evaluated for diverse parameters which include hardness, friability, weight variation, drug content uniformity, water absorption ratio, in vitro drug release, and wetting time. Results: The hardness of all formulations from F1 to F7 proved that the tablet means thickness was nearly uniform in all formulations with the range of 0.520 mm–0.522 mm. Water absorption of prepared formulations was found to be 68.59%–73.21%. Bulk density, tapped density, and friability of the formulations were established within the limits, results of in vitro drug release study showed the drug released between 90.27% and 96.17% at 60 min. Conclusion: The overall study concluded that orodispersible tablets of trazodone hydrochloride have greater dissolution rate and will result in enhanced bioavailability. The taste masked systems are designed to provide better acceptability, improved bioavailability, for chronic patients. The study results revealed that the formulation F6 was contemplated as the top formulation.

scholarly journals Formulation Study of a Co-Processed, Rice Starch-Based, All-in-One Excipient for Direct Compression Using the SeDeM-ODT Expert System

2021 ◽  
Vol 14 (10) ◽  
pp. 1047
Author(s):  
Karnkamol Trisopon ◽  
Nisit Kittipongpatana ◽  
Phanphen Wattanaarsakit ◽  
Ornanong Suwannapakul Kittipongpatana
Keyword(s):  
Expert System ◽  
Tablet Formulation ◽  
Physical Mixture ◽  
Rice Starch ◽  
Direct Compression ◽  
Dissolution Profile ◽  
Drug Content ◽  
Weight Variation ◽  
Pharmaceutical Properties

A co-processed, rice starch-based excipient (CS), previously developed and shown to exhibit good pharmaceutical properties, is investigated as an all-in-one excipient for direct compression (DC). An SeDeM-ODT expert system is applied to evaluate the formulation containing CS, in comparison with those containing the physical mixture and the commercial DC excipients. The results revealed that CS showed acceptable values in all six incidence factors of the SeDeM-ODT diagram. In addition, the comprehensive indices (IGC and IGCB) were higher than 5.0, which indicated that CS could be compressed with DC technique without additional blending with a disintegrant in tablet formulation. The formulation study suggested that CS can be diluted up to 60% in the formulation to compensate for unsatisfactory properties of paracetamol. At this percentage, CS-containing tablets exhibited narrow weight variation (1.5%), low friability (0.43%), acceptable drug content (98%), and rapid disintegration (10 s). The dissolution profile of CS displayed that more than 80% of the drug content was released within 2 min. The functionality of CS was comparable to that of high functionality excipient composite (HFEC), whereas other excipients were unsuccessful in formulating the tablets. These results indicated that CS was a suitable all-in-one excipient for application in DC of tablets.

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