scholarly journals The Effect of Manufacturing Methods and Different Shapes on the Release Pattern of Diclofenac Sodium Matrix Tablet

1970 ◽  
Vol 2 (2) ◽  
pp. 76-80
Author(s):  
Tajnin Ahmed ◽  
Muhammad Shahidul Islam ◽  
Tasnuva Haque ◽  
Mohammad Abusyed
Keyword(s):  
Sustained Release ◽  
Release Rate ◽  
Diclofenac Sodium ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Compression Method ◽  
Release Pattern ◽  
Peg 600

In the present study sustained release diclofenac sodium matrix tablets were prepared using Kollidon SR polymer. Hydroxypropyl methylcellulose (HPMC 15 cps) and poly ethylene glycol (PEG-600) polymers respectively were used in formulating tablets prepared by direct compression and wet granulation methods. The polymers were used to explore the release pattern of the drug into the dissolution media. The tablets were also prepared in various shapes (caplet oval, round oval and flat oval). A comparatively higher release rate of drug was obtained from the polymer HPMC 15 cps at 10% concentration for directly compressed matrix tablet than those containing 20% of HPMC after a definite period of time. In wet granulation process, 10% PEG-600 containing tablets showed a better release than those containing 20% PEG. The drug release was also found to be sustained in case of wet granulation method than that of the direct compression method. Again the caplet shaped tablets in case of direct compression method showed better release rate of drug than those of the round oval and flat oval shaped tablets. Thus the result of this study shows that the proper selection of the percentage of polymer and the suitable shape of tablet and proper manufacturing method can provide a greater opportunity in designing sustained release dosage forms. Key words: Matrix tablet; release pattern; direct compression; wet granulation; PEG 600; Kollidon SR.DOI: 10.3329/sjps.v2i2.5828Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 76-80

scholarly journals FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF LORNOXICAM BY DIRECT COMPRESSION METHOD

2021 ◽  
Vol 10 (5) ◽  
pp. 131-136
Author(s):  
Asim pasha ◽  
C N Somashekhar
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Prolonged Release ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Dissolution Profile ◽  
Drug Content

The aim of the present work was to develop sustained release Lornoxicam matrix tablets with polymers like HPMC K15M, Ethyl cellulose, and Crospovidone as carriers in varying quantities. Direct compression was used to make matrix tablets. Various assessment parameters, such as hardness, friability, thickness, percent drug content, weight variation, and so on, were applied to the prepared formulations. In vitro dissolution studies were carried out for 24 hrs. The tablets were subjected to in-vitro drug release in (pH 1.2) for first 2 hrs. Then followed by (pH 6.8) phosphate buffer for next 22 hrs. And the results showed that among the six formulations FL3 showed good dissolution profile to control the drug release respectively. The drug and polymer compatibility were tested using FT-IR spectroscopy, which revealed that the drug was compatible with all polymers. It is also required to design an appropriate prolonged release formulation for Lornoxicam in order to maintain the drug's release. Hence by using the compatible polymers sustained release tablets were formulated and subjected for various types of evaluation parameters like friability, hardness, drug content and dissolution behaviour. Finally, the findings reveal that the prepared sustained release matrix tablets of lornoxicam have improved efficacy and patient compliance.

scholarly journals Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets: Influence of Some Hydrophillic Polymers on the Release

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Amitava Roy ◽  
Kalpana Roy ◽  
Sarbani Roy ◽  
Jyotirmoy Deb ◽  
Amitava Ghosh ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Hydroxypropyl Methylcellulose ◽  
Dissolution Kinetics ◽  
Matrix Tablets ◽  
Metformin Hydrochloride ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Response Surface Optimization

The aim of the present work was designed to develop a model-sustained release matrix tablet formulation for Metformin hydrochloride using wet granulation technique. In the present study the formulation design was employed to statistically optimize different parameters of Metformin hydrochloride tablets at different drug-to-polymer ratios employing polymers Hydroxypropyl methylcellulose of two grades K4M and K100M as two independent variables whereas the dependent variables studied were X60, X120, T50, T90, n, and b values obtained from dissolution kinetics data. The in vitro drug release studies were carried out at simulated intestinal fluids, and the release showed a non-Fickian anomalous transport mechanism. The drug release was found to reveal zero order kinetics. The granules and the tablets were tested for their normal physical, morphological, and analytical parameters and were found to be within the satisfactory levels. There were no significant drug-polymer interactions as revealed by infrared spectra. It has been found out that on an optimum increased Hydroxypropyl methylcellulose K100M concentration and decreased Hydroxypropyl methylcellulose K4M concentration the formulations were elegant in terms of their release profiles and were found to be statistically significant and generable.

scholarly journals Formulation and Evaluation of Gabapentin Sustained Release Matrix Tablet Using Hibiscus rosa sinensis Leaves Mucilage as Release Retardant

2021 ◽  
pp. 564-572
Author(s):  
P. Amsa ◽  
G. K. Mathan ◽  
S. Magibalan ◽  
E. K. Velliyangiri ◽  
T. Kalaivani ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Magnesium Stearate ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Hibiscus Rosa Sinensis

The major goal of this study was to develop and evaluate Sustained release matrix tablets of Gabapentin with Hibiscus rosa - sinensis leaves mucilage prepared by using wet granulation technique with microcrystalline cellulose as a diluents and magnesium stearate as a lubricant. Pre-compression and post-compression evaluation of physicochemical parameters were carried out and to be within acceptable limits. Drug and polymer compatibility were validated by FTIR measurements. Further, tablets were evaluated for in vitro release study. To get the sustained release of Gabapentin, the concentration of Hibiscus rosa- sinensis mucilage was tuned with a gas-generating agent. The % drug release of all formulation from F1 to F5 showed 91.24%, 80.24%, 70.53%, 62.12% and 49.83% respectively. All the dosage form release kinetics was computed using zero order, first order, Higuchi, and Korsmeyer–Peppas methods. From the above results, it is concluded that the n value of formulation F5 showed 0.78 suggesting anomalous (non-fickian) behavior of the drug. Mucilage from the leaves of Hibiscus rosa-sinensis has a great retarding effect in drug release from sustained release tablets.

scholarly journals Formulation and evaluation of sustained release diclofenac sodium matrix tablets produced using Brachystegia eurycoma gum

2020 ◽  
Vol 17 (1) ◽  
pp. 34-43
Author(s):  
Sinodukoo E. Okafo ◽  
John A. Avbunudiogba ◽  
Ejiro Ejomafuvwe
Keyword(s):  
Sustained Release ◽  
Diclofenac Sodium ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Content Uniformity ◽  
Drug Release Profile ◽  
Hydrophilic Matrix ◽  
Weight Content ◽  
The Matrix ◽  
Hardness Values

This study was carried out to evaluate sustained release diclofenac sodium matrix tablets formulated using Brachystegia eurycoma gum (BEG) as matrix polymer. BEG was isolated by acetone -precipitation of the filtrate obtained from the maceration of powdered dried seeds of Brachystegia eurycoma in distilled water. Diclofenac sodium matrix tablets were produced by non-aqueous wet granulation method using BEG as the hydrophilic matrix former. The tablets were evaluated using official and unofficial tests such as; uniformity of weight, content uniformity, dissolution test, tablets diameter, thickness, hardness and friability tests. The drug release profile of the matrix tablets were compared to that formulated using a standard matrix former, hydroxypropylmethylcellulose (HPMC). Hardness values ranged from 6.12 ± 1.80 to 9.73 ± 1.39 kgf, friability from 0.31 ± 0.00 to 1.00 ± 0.00%. The drug content ranged from 98 to 101 %. The percentage drug released from the matrix tablets after 10 h was between 71.27 and 98.73 % except for formulation BF3 that released 32.56 %. This study showed that sustained release diclofenac sodium matrix tablets were  successfully formulated using Brachystegia eurycoma gum as the matrix former and the tablets were comparable to that formulated with HPMC. Keywords: Brachystegia eurycoma gum; Diclofenac sodium; Matrix tablets; Sustained release

scholarly journals Formulation of Sustained-Release Matrix Tablet of Rotundin Sulfat

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Do Thi Ha ◽  
Nguyen Thanh Hai ◽  
Tran Thi Van Anh ◽  
Ha Thanh Hoa ◽  
Pham Thi Minh Hue
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Hydroxypropyl Methylcellulose ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Viet Nam ◽  
Pharmaceutical Sciences ◽  
Release Process ◽  
Tablet Hardness

Sustained-release matrix tablets containing rotundin sulfat are prepared by a wet granulation method. The influence of Metholose 100.000 RS,  4000 SR, Avicel PH101, lactose and tablet compression force on the ability to release rotundin from the tablets has been evaluated. Modde 8.0 software was used in the experiment. The influencing factors were evaluated by software FormRules v2.0 and the optimal formula predicted by the INForm v3.1 was optimized. The selected optimal formulation of rotundin sulfate tablets for a drug release process lasting 8 hours contained Metholose 100.000 RS 120 mg; Avicel PH101 24.0 mg; lactose 34.5 mg; and 8 kP tablet hardness. Keywords Rotundin sulfat, matrix tablet, sustained release, optimizing. References [1] Đỗ Tất Lợi, Những cây thuốc và vị thuốc Việt Nam, NXB Thời Đại (2011), 779. [2] Nguyễn Minh Chính và CS, Nghiên cứu tách chiết rotundin để sản xuất thuốc tiêm rotundin sulfat, Tạp chí Y Dược học Quân sự. 1 (1999) 55-56. [3] Nguyễn Thanh Hải, Bùi Thanh Tùng, Phạm Thị Minh Huệ (2017), Phỏng sinh học trong y dược học – Hướng nghiên cứu cần đẩy mạnh, Tạp chí khoa học ĐHQGHN, Khoa học Y Dược. 33(1) (2017) 1-4. [4] Bộ Y tế, Dược điển Việt Nam V, Nhà xuất bản Y học, 1 (2017), 842-844. [5] M. Levina, A.R. Rajabi-Siaboomi, The influence of excipients on drug release from hydroxypropyl methylcellulose matrices, Journal of Pharmaceutical Sciences. 93(11) (2004) 2746-2754. [6] Nguyễn Minh Chính, Nguyễn Thị Hồng Thắm, Nguyễn Văn Bạch, Tối ưu hóa công thức bào chế viên nén rotundin sulfat giải phóng kéo dài, Tạp chí Y Dược học Quân sự. số CĐ Dược (2016), 61-67. [7] N. Aruna, K.M. Babu, Formulation and evaluation of sustained release matrix tablets containing metformin HCl and Syzygium cumini, International Journal of Pharmaceutical and Biological Archive. 2(3) (2011), 900-905. [8] B.J. Lee, et al, Formulation and release charecteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin, Drug Development and Industrial Pharmacy. 25 (1999) 493-501.[9] A. Nokhochi, J.L. Ford, P. Rowe, et al, The e ffects of compression rate and force on the compaction properties of different viscosity grades of hydroxypropyl methylcellulose 2208, International Journal of Pharmaceutics. 129 (1996), 21-31.  

scholarly journals Formulations of sustained release matrix tablets of Furosemide using natural and synthetic polymers

2021 ◽  
Vol 11 (5) ◽  
pp. 105-109
Author(s):  
Shivani Soni ◽  
Vivek Jain ◽  
Sunil Kumar Jain ◽  
Pushpendra Kumar Khangar
Keyword(s):  
Sustained Release ◽  
Xanthan Gum ◽  
Dosage Form ◽  
Spectroscopic Method ◽  
Synthetic Polymers ◽  
Matrix Tablets ◽  
Matrix Tablet ◽  
Direct Compression ◽  
The Matrix ◽  
Pharmaceutical Industries

The primary benefit of a sustained release dosage form compared to a conventional dosage form, is the consistent drug plasma concentration and consequently uniform therapeutic effect. Matrix system are preferential because of their ease, patient compliance etc, than  traditional drug delivery which have several drawbacks like reiterated administration, variation in blood concentration level etc. The aim of the present research study was to develop and evaluate sustained release matrix tablets of furosemide using direct compression method using  natural  gummy  and  waxy  materials (Xanthan  gum, bees  wax)  and synthetic  polymers  (HPMC K4M). The matrix tablet formulations were prepared by using different drug: polymer ratios (1:1, 1:2 and 1:3). All formulations were assessed using micromeritics studies of powder blend and diverse physicochemical tests. All the physicochemical characters of the formulated tablets were within acceptable limits. The release pattern of the drug was viewed over a period of 12 hours and determined the amount of drug by the UV-Visible spectroscopic method. Dissolution data demonstrated that the formulated tablets with Xanthan gum and hydroxyl propyl methylcellulose (HPMC) provided sustained release of the drug up to 12 hrs. Therefore inexpensively it may be appropriate for the pharmaceutical industries to employ this kind of simple technologies for the expansion of advanced formulations. Hence, we conclude that the purpose of this study was to formulate a sustained release matrix tablet of furosemide using diverse polymers and their dissimilar proportions have been attained. Keywords: Furosemide, Direct compression, Natural, Synthetic polymers, Sustained release tablets.

scholarly journals Formulation and In-vitro evaluation of sustained release matrix tablet of Metformin hydrochloride

2019 ◽  
Vol 9 (3) ◽  
pp. 95-98
Author(s):  
Ravi U Gaware ◽  
Gayatri R Waykar ◽  
Madhuri K Yewale ◽  
Rutuja B Mhaske ◽  
Poonam S Mhaske
Keyword(s):  
Sustained Release ◽  
Ethyl Cellulose ◽  
Metformin Hydrochloride ◽  
High Dose ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Compression Method ◽  
Hydrophilic Matrix ◽  
Compaction Behavior

The low bioavailability and short half-life of Metformin hydrochloride (MH) make the development of sustained-release forms desirable. Present work involves preparation and optimization of sustained release matrix tablet of MH by direct compression method using HPMC K 100 and ethyl cellulose as a matrix forming polymer. Avicel was added as a direct compaction vehicle to improve the compaction behavior of Metformin which otherwise exhibits poor compaction behavior which again is further increased by its relatively high dose. Hydrophilic matrix of HPMC alone resulted in initial burst of Metformin release, however when combined with ethyl cellulose drug release was slowed down and thereafter it became optimal at particular concentration of polymers. Keywords:  Metformin, HPMC, Ethyl cellulose, sustained release, matrix, tablet.

scholarly journals Formulation and evaluation of sustain released matrix tablet of atenolol

2019 ◽  
Vol 9 (1) ◽  
pp. 183-189 ◽  
Author(s):  
Sonal Sahu ◽  
Rohit Dangi ◽  
Rohit Patidar ◽  
, Rukhsaar ◽  
Jagdish Rathi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dosage Form ◽  
Oral Route ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Natural Polymer ◽  
Flexible Design ◽  
Weight Variation

Oral route is one of the most popular routes of drug delivery due to its ease of administration, patient compliance, least sterility constraints and flexible design of dosage form. The aim of present investigation was to develop matrix tablets of atenolol using different polymers. Atenolol matrix tablets were prepared by direct compression and wet granulation method using different polymers. All the formulations were evaluated for weight variation, thickness, hardness, friability and dissolution. Tablets of atenolol were prepared utilizing natural polymer chitosan. The formulation F-2 contained chitosan which might have sustained the release since it is also known for its polymeric sustaining effect. The formulation F-2 gave 89.57±0.24% of the drug release in 12 hrs of study. Keywords: Atenolol, Sustained release Matrix tablets, Direct compression, Wet granulation method.

scholarly journals In Vitro Release Kinetic Study of Ciprofloxacin HCl from Methocel K15M CR, Methocel K4M CR and Methocel K4M Premium Matrix Tablets

1970 ◽  
Vol 2 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Muhammad Shahidul Islam ◽  
Tasnuva Haque ◽  
Rumana Jahangir ◽  
Kanij Fatema ◽  
Mynol Islam Vhuiyan ◽  
...  
Keyword(s):  
Release Rate ◽  
Release Kinetics ◽  
Hydroxypropyl Methylcellulose ◽  
In Vitro Release ◽  
Matrix Tablets ◽  
Release Kinetic ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Kinetic Order ◽  
Kinetics Of

In the present study Ciprofloxacin HCl sustained release matrix tablet was prepared by utilizing different grades of hydroxypropyl methylcellulose (HPMC) polymers such as Methocel K4M CR, Methocel K4M Premium & Methocel K15M CR by direct compression method. Different amount of Methocel K15M CR was used to develop matrix builder in the three proposed formulations (F1-F3) for the study of release rate retardant effect at 5%, 6%, and 7% of total weight of tablet matrix respectively. The dissolution study of Methocel K15M CR based tablet matrices of those proposed formulations were carried out in the simulated gastric medium (pH 1.3) for 8 hours using USP dissolution apparatus II. Similarly Methocel K4M premium was used to develop matrix builder in another three proposed formulations (F4-F6). It was found that formulations F-4 (15%), F-5 (17%) and F-6 (18.3%) met the desired release rate of Ciprofloxacin HCl for 8hrs period. The release kinetics of formulation F-4, F-5 and F-6 followed Higuchi kinetic order. Again Methocel K4M premium was used for another three proposed formulations (F7-F9). It was found that formulations F-7 (6.7%), F-8 (12.3%) and F-9 (15.6%) met the desired release rate of Ciprofloxacin HCl for 8hrs period. The release kinetics of formulation F-7, F-8 and F-9 followed Higuchi kinetic order. Among these three polymers, Methocel K4M Premium showed better release retardant effect than Methocel K4M CR and Methocel K15M CR. Key Words: Ciprofloxacin HCl; Direct compression; Controlled release; Methocel K15M CR; Methocel K4M CR; Methocel K4M premium.DOI: 10.3329/sjps.v2i1.5814Stamford Journal of Pharmaceutical Sciences Vol.2(1) 2009: 37-43

Studying the Release Characteristics of Naproxen Sustained Release Matrix Tablet Using Natural Polyelectrolytes

2019 ◽  
Vol 9 (o3) ◽  
Author(s):  
Zahraa Oleiwi Hamzah ◽  
Wedad K. Ali
Keyword(s):  
Molecular Weight ◽  
Sustained Release ◽  
Release Rate ◽  
Matrix Tablets ◽  
Matrix Tablet ◽  
Anionic Polymer ◽  
Ft Ir ◽  
Dissolution Apparatus ◽  
Physical Mixtures ◽  
Polymer Ratio

Aim: This work involves studying the release characteristics of naproxen sustained release matrix tablet using natural polyelectrolytes and studying some variables affecting the formulation such as the effects of (PEC formation, polymer-polymer ratio, anionic polymer type, molecular weight of CS, type and amount of diluent) on the release rate of naproxen. Methods: Sixteen formula were prepared using direct compression with 500 mg total tablet weight. The release properties of naproxen sustained release matrix tablets were investigated using USP dissolution apparatus I (basket). FT-IR spectra of the complexes were studied to indicate the interactions between polyions. Results: The results showed that the release rate of naproxen was decreased in the formulas that contains PEC comparing to the formulas with single polymer. The formula containing CSh: SA prepared in the ratio of (3:1) showed the slowest release rate (68.17% of naproxen in 7 hr) and extended the release up to 15 hr. It was seen that the formula containing CSh: XG in 3:1 ratio formed the strongest PEC and the release rate extended up to 20 hr. On the other hand changing the molecular weight of CS from high to low and the type of diluent from lactose monohydrate to MCC showed a non-significant increase in the release rate. Conclusion: Polyelectrolyte complex prepared from cationic polymer CS and anionic polymer of SA, XG and CG physical mixtures was successfully formed. Formula 13 formed the strongest PEC with a ratio of CS: XG equal to (3:1) which extended the release up to 20 hr.

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