Stem Cells in Head and Neck Cancers Pathogenesis: Are Advanced Glycation End Products (AGEs) Involved?

2018 ◽  
Vol 04 (02) ◽  
Author(s):  
Petrescu Bianca Nausica ◽  
Babtan Anida Maria ◽  
Soritau Olga ◽  
Buhate Dan ◽  
Ionel Anca ◽  
...  
Keyword(s):  
Stem Cells ◽  
Head And Neck ◽  
Advanced Glycation End Products ◽  
Head And Neck Cancers ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Advanced Glycation End Products Impair Cardiac Atrial Appendage Stem Cells Properties

2021 ◽  
Vol 10 (13) ◽  
pp. 2964
Author(s):  
Lize Evens ◽  
Ellen Heeren ◽  
Jean-Luc Rummens ◽  
Annelies Bronckaers ◽  
Marc Hendrikx ◽  
...  
Keyword(s):  
Stem Cells ◽  
Advanced Glycation End Products ◽  
Atrial Appendage ◽  
Advanced Glycation ◽  
Negative Effects ◽  
Glycation End Products ◽  
End Products ◽  
Negative Effect ◽  
Migration Capacity

Background: During myocardial infarction (MI), billions of cardiomyocytes are lost. The optimal therapy should effectively replace damaged cardiomyocytes, possibly with stem cells able to engraft and differentiate into adult functional cardiomyocytes. As such, cardiac atrial appendage stem cells (CASCs) are suitable candidates. However, the presence of elevated levels of advanced glycation end products (AGEs) in cardiac regions where CASCs are transplanted may affect their regenerative potential. In this study, we examine whether and how AGEs alter CASCs properties in vitro. Methods and Results: CASCs in culture were exposed to ranging AGEs concentrations (50 µg/mL to 400 µg/mL). CASCs survival, proliferation, and migration capacity were significantly decreased after 72 h of AGEs exposure. Apoptosis significantly increased with rising AGEs concentration. The harmful effects of these AGEs were partially blunted by pre-incubation with a receptor for AGEs (RAGE) inhibitor (25 µM FPS-ZM1), indicating the involvement of RAGE in the observed negative effects. Conclusion: AGEs have a time- and concentration-dependent negative effect on CASCs survival, proliferation, migration, and apoptosis in vitro, partially mediated through RAGE activation. Whether anti-AGEs therapies are an effective treatment in the setting of stem cell therapy after MI warrants further examination.

PPARγ-mediated advanced glycation end products regulation of neural stem cells

2009 ◽  
Vol 307 (1-2) ◽  
pp. 176-184 ◽  
Author(s):  
Shao-hua Wang ◽  
Zi-lin Sun ◽  
Yi-jing Guo ◽  
Yang Yuan ◽  
Ling Li
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Lize Evens ◽  
Hanne Beliën ◽  
Dorien Deluyker ◽  
Annelies Bronckaers ◽  
Pascal Gervois ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Viability ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
Proliferation And Apoptosis ◽  
End Products

Stem cell-based regenerative therapies hold great promises to treat a wide spectrum of diseases. However, stem cell engraftment and survival are still challenging due to an unfavorable transplantation environment. Advanced glycation end-products (AGEs) can contribute to the generation of these harmful conditions. AGEs are a heterogeneous group of glycated products, nonenzymatically formed when proteins and/or lipids become glycated and oxidized. Our typical Western diet as well as cigarettes contain high AGEs content. AGEs are also endogenously formed in our body and accumulate with senescence and in pathological situations. Whether AGEs have an impact on stem cell viability in regenerative medicine remains unclear, and research on the effect of AGEs on stem cell proliferation and apoptosis is still ongoing. Therefore, this systematic review provides a clear overview of the effects of glycated proteins on cell viability in various types of primary isolated stem cells used in regenerative medicine.

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