Low Serum Phosphorus Levels and Acute Ischemic Stroke

Low serum vitamin D levels have been associated with various vascular diseases. Very little is known its association with acute stroke in Bangladeshi population. We therefore sought to assess whether low serum 25- hydroxyvitamin D, a marker of vitamin D status is associated with acute stroke. We performed a prospective study in Comilla Medical Collage, Comilla, from November 2016 to November 2017. All the patients diagnosed as acute ischemic stroke on the basis of CT scan or MRI of brain. Patients were eligible for inclusion if they were admitted with onset of symptoms within 24 hours. Estimation of 25(OH)D level was done at presentation. The patients were stratified by vitamin D status, >30 as vitamin D sufficient, vitamin D 20-20.9 as insufficient and finally vitamin D<20 as deficient. Multivariate logistic regression analysis revealed that out of the desired 7 variables, smoking, hypertension and low serum vitamin D were found independent predictors for acute stroke with ORs being 1.44, 4.23 and 2.39 respectively. Vitamin D deficiency represents an important risk factor for acute stroke and it might play a causal role in the development adverse events associated with stroke.Medicine Today 2018 Vol.30(1): 34-37

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Low serum TNF-related apoptosis-inducing ligand (TRAIL) levels are associated with acute ischemic stroke severity

Atherosclerosis ◽

10.1016/j.atherosclerosis.2015.03.028 ◽

2015 ◽

Vol 240 (1) ◽

pp. 228-233 ◽

Cited By ~ 8

Author(s):

Yang Ho Kang ◽

Min-Gyu Park ◽

Kyung-Ha Noh ◽

Hae Rim Park ◽

Hye Won Lee ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Stroke Severity ◽

Low Serum

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Serum Phosphorus and Albumin in Patients Undergoing Peritoneal Dialysis: Interaction and Association With Mortality

Frontiers in Medicine ◽

10.3389/fmed.2021.760394 ◽

2021 ◽

Vol 8 ◽

Author(s):

Naya Huang ◽

Huiyan Li ◽

Li Fan ◽

Qian Zhou ◽

Dongying Fu ◽

...

Keyword(s):

Risk Factors ◽

Peritoneal Dialysis ◽

Serum Albumin ◽

Cardiovascular Mortality ◽

Elevated Risk ◽

Serum Phosphorus ◽

Low Phosphorus ◽

Low Serum ◽

Phosphorus Levels ◽

High Albumin

Hyperphosphatemia and hypoalbuminemia confer worse clinical outcomes, whether these risk factors interact to predispose to mortality is unclear. In this prospective cohort study, 2,118 patients undergoing incident continuous ambulatory peritoneal dialysis (CAPD) were enrolled and categorized into four groups based on the changing point regarding mortality at 1.5 mmol/L for serum phosphorus and 35 g/L for serum albumin. Risks of all-cause and cardiovascular mortality were examined independently and interactively in overall and subgroups. There was no association between serum phosphorus with all-cause and cardiovascular mortality, but significant interactions (p = 0.02) between phosphorus and albumin existed in overall population. Patients in subgroup with high phosphorus and low albumin were at greater risk of all-cause (HR 1.95, 95%CI 1.27–2.98, p = 0.002) but not cardiovascular mortality (HR 0.37, 95%CI 0.10–1.33, p = 0.13), as compared to those with low phosphorus and high albumin. In contrast, patients with both low parameters had a higher risk of all-cause (HR 1.75, 95%CI 1.22–2.50, p = 0.002) and cardiovascular mortality (HR 1.92, 95%CI 1.07–3.45, p = 0.03). Notably, an elevated risk of both all-cause and cardiovascular mortality was observed in those with low serum albumin, irrespective of phosphorus levels, suggesting low albumin may be useful to identify a higher-risk subgroup of patients undergoing CAPD with different serum phosphorus levels.

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Low Serum n-3 Polyunsaturated Fatty Acid/n-6 Polyunsaturated Fatty Acid Ratio Predicts Neurological Deterioration in Japanese Patients with Acute Ischemic Stroke

Cerebrovascular Diseases ◽

10.1159/000355683 ◽

2013 ◽

Vol 36 (5-6) ◽

pp. 388-393 ◽

Cited By ~ 28

Author(s):

Satoshi Suda ◽

Toshiya Katsumata ◽

Seiji Okubo ◽

Takuya Kanamaru ◽

Kentaro Suzuki ◽

...

Keyword(s):

Ischemic Stroke ◽

Fatty Acid ◽

Acute Ischemic Stroke ◽

Polyunsaturated Fatty Acid ◽

Japanese Patients ◽

Neurological Deterioration ◽

Fatty Acid Ratio ◽

Acid Ratio ◽

Low Serum

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Estimation of Vitamin D Levels in Acute Ischaemic Stroke - A Study from Amritsar, Punjab

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/593 ◽

2021 ◽

Vol 8 (35) ◽

pp. 3264-3268

Author(s):

Pooja Parteek ◽

Manish Chandey ◽

Satya Nayyar ◽

Poonam Verma ◽

Raminder Singh

Keyword(s):

Vitamin D ◽

Ischemic Stroke ◽

Ischaemic Stroke ◽

Acute Ischemic Stroke ◽

Acute Ischaemic Stroke ◽

Serum Vitamin ◽

Mean Value ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Low Serum

BACKGROUND World Health Organization (WHO) defines stroke as “rapidly developing clinical signs of focal (or global) disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than that of vascular origin.” Low serum 25 hydroxy vitamin D is associated with large infarct volume, which worsens the outcome in ischemic stroke patients. In this study, we wanted to evaluate serum vitamin D levels in acute ischaemic stroke (AIS) patients and correlate the severity of stroke with lipid profile & central nervous system (CNS). METHODS It was a cross sectional comparative study, conducted in Department of Medicine in SGRDIMSR, Sri Amritsar from December 2018 to June 2020. A total of 100 subjects, 50 cases of AIS, diagnosed by history, clinical examination and supported by magnetic resonance imaging (MRI) of brain and 50 age and sex matched healthy controls were enrolled for the present study to estimate serum vitamin D level in AIS. Detailed clinical history and clinical examination were done on all participating subjects and relevant investigations were done. Diagnosis was confirmed by MRI brain in acute ischemic stroke cases. The severity of neurological impairment was evaluated as per Canadian neurological stroke scale within 24 hours of admission of the cases. RESULTS Mean age of cases was 62.06 ± 10.52 years and mean age of control was 59.14 ± 11.36 with maximum number of subjects were in age group of 61 - 70 years. The mean value of vitamin D in study group was 19.31 ± 9.24 while in control group, mean value was 36.42 ± 8.33, showing more serum vitamin D deficiency in cases having AIS than controls. (P value 0.021). CONCLUSIONS The present study suggests that the low serum vitamin D levels in the body is associated with more severe neurological deficit. KEYWORDS Stroke, Serum Vitamin D, Acute Ischemic Stroke, Canadian Neurological Scale

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