Determination of Mitochondrial DNA Upon Drug Treatment

BIO-PROTOCOL ◽  
2015 ◽  
Vol 5 (2) ◽  
Author(s):  
Michel Perron ◽  
Joy Feng
2008 ◽  
Vol 12 (6) ◽  
pp. 462-465 ◽  
Author(s):  
Pedro Carnieli Junior ◽  
Willian de Oliveira Fahl ◽  
Juliana Galera Castilho ◽  
Paulo Eduardo Brandão ◽  
Maria Luiza Carrieri ◽  
...  

2015 ◽  
Vol 135 (10) ◽  
pp. 2512-2518 ◽  
Author(s):  
Jennifer A. Latimer ◽  
James J. Lloyd ◽  
Brian L. Diffey ◽  
Paul J. Matts ◽  
Mark A. Birch-Machin

2018 ◽  
Vol 25 (11) ◽  
pp. 1535-1538 ◽  
Author(s):  
Nicolas Fissolo ◽  
Laura Cervera-Carles ◽  
Luisa María Villar Guimerans ◽  
Alberto Lleó ◽  
Jordi Clarimón ◽  
...  

The role of cerebrospinal fluid (CSF) mitochondrial DNA (mtDNA) levels as biomarker in multiple sclerosis (MS) is unknown. We determined CSF mtDNA levels in a cohort of 237 individuals, including patients with MS and clinically isolated syndrome (CIS), inflammatory and non-inflammatory neurological controls, and cognitively healthy controls (HC). mtDNA concentration was measured by droplet digital polymerase chain reaction. CSF mtDNA levels were increased in all pathological conditions compared with HC, though no differences were observed between relapse-onset and progressive MS clinical forms, CIS patients and neurological controls. These findings do not support the determination of CSF mtDNA levels as a useful biomarker in MS clinical practice.


2018 ◽  
Vol 2_2018 ◽  
pp. 44-49 ◽  
Author(s):  
Skripnichenko Yu.P. Skripnichenko ◽  
Baranov I.I. Baranov ◽  
Vysokikh M.Yu. Vysokikh ◽  
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