Comparative Clinical and Pathomorphological Characteristics of Dupuytren’s Contracture in Men and Women

Background. The data available in the literature on the features of the clinical course and functional prognosis of Dupuytren`s disease in women is contradictory, there are no data on comparative pathomorphological studies of palmar fibromatosis in men and women.The aim of the study was to identify possible differences in the clinical and pathomorphological characteristics of Dupuytren`s disease in men and women.Materials and Methods. 228 cases of men and 39 women (6:1) who underwent fasciectomy in 2013–2019 period were analyzed. Histomorphometry of paraffin sections of the patient`s palmar fascia specimens of 24 men and 24 women was performed.Results. Men ranged in age from 26 to 83, the median age is 3 years more in women (p<0.001), but the median age of Dupuytren`s disease debut is 2 years less in women (p<0.001). The frequency of contractures of the 3rd–4th degree was 35.9% in the group of women and 65% in the group of men (p<0.001). In the group of women the frequency of both hands involvement is 15.2% higher, I–III fingers involvement is 8.7% higher, recurrent contracture is 11.1% higher (p<0.1). Histomorphometric analysis of the patient`s palmar fascia specimens showed that women compared to men had 10.23% less adipose tissue (p<0.001), 7.87% less dense connective tissue (p<0.05), but the proportion of hyperplastic connective tissue was 20.31% higher.Conclusion. Dupuytren`s disease is less common in women, than men. Women seek surgical treatment earlier than men. The tendency to functional limitations intensification and the risk of recurrence in women is associated with higher expression of hyperplastic changes in the fascial structures of the hand.

Download Full-text

Thymus-dependent lymphocyte levels in bronchogenic carcinoma: Correlations with histology, clinical stage, and clinical course after surgical treatment

Cancer ◽

10.1002/1097-0142(197503)35:3<687::aid-cncr2820350322>3.0.co;2-u ◽

1975 ◽

Vol 35 (3) ◽

pp. 687-694 ◽

Cited By ~ 68

Author(s):

A. Lee Dellon ◽

Claude Potvin ◽

Paul B. Chretien

Keyword(s):

Surgical Treatment ◽

Bronchogenic Carcinoma ◽

Clinical Course ◽

Clinical Stage

Download Full-text

Lipoma of the left tonsillar fossa

The Journal of Laryngology & Otology ◽

10.1017/s0022215100127252 ◽

1994 ◽

Vol 108 (6) ◽

pp. 507-508 ◽

Cited By ~ 6

Author(s):

R. Benson-Mitchell ◽

N. Tolley ◽

C. B. Croft ◽

D. Roberts

Keyword(s):

Adipose Tissue ◽

Connective Tissue ◽

Literature Review ◽

Clinical Presentation ◽

Aerodigestive Tract ◽

Upper Aerodigestive Tract ◽

Tonsillar Fossa ◽

Subcutaneous Tissues

AbstractLipomas are common benign connective tissue tumours composed of adult adipose tissue. They are relatively rare in the upper aerodigestive tract, although they occur with considerable frequency in other areas, particularly in the subcutaneous tissues of the neck. Although there are several reports of this tumour occurring in the oropharynx, there is no recorded case of a lipoma of the tonsillar fossa. An 83-year-old man with a left tonsillar fossa lipoma is presented. Clinical presentation, management and a literature review are discussed.

Download Full-text

Iatrogenic Teratoma Rupture during TVOR Complicated with Peritonitis, Pleuritis, and Septic Shock

Case Reports in Obstetrics and Gynecology ◽

10.1155/2018/3126436 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4

Author(s):

Pei-Yi Wang ◽

Yi-En Chang ◽

Yu-Chieh Lee ◽

Chii Ruey Tzeng

Keyword(s):

Septic Shock ◽

Surgical Treatment ◽

Rare Case ◽

Clinical Course ◽

Oocyte Retrieval ◽

Chemical Irritation ◽

Chemical Peritonitis ◽

Purulent Fluid ◽

Exploratory Laparoscopy ◽

Transvaginal Oocyte Retrieval

Objective. To obtain a better understanding of the clinical course and the subsequent complications of teratoma rupture. Case. We report a rare case of chemical peritonitis and pleuritis caused by teratoma rupture during ultrasonographically guided transvaginal oocyte retrieval (TVOR). The patient initially presented with nonspecific and digestive symptoms after TVOR, but the condition deteriorated rapidly after three weeks with peritonitis and septic shock. Thus, exploratory laparoscopy was performed with the findings of a ruptured teratoma at left adnexa, severe adhesions, and purulent fluid in her peritoneal cavity. Bilateral pleuritis was also noted after the operation, which was suspected to be caused by chemical irritation of the spilled contents of the teratoma. The patient’s condition improved after surgical treatment and was discharged 28 days after admission. Conclusion. Our case showed that the timing of peritoneal irritation caused by teratoma rupture converting to severe chemical peritonitis was approximately 3 weeks. Physicians should avoid cyst puncture during TVOR and closely observe or even perform surgical treatment when iatrogenic teratoma ruptures are suspected.

Download Full-text

Atypical clinical course of cerebral arachnoid cyst

Patologiya krovoobrashcheniya i kardiokhirurgiya ◽

10.21688/1681-3472-2013-2-77-78 ◽

2015 ◽

Vol 17 (2) ◽

pp. 77

Author(s):

A. L. Krivoshapkin ◽

A. V. Gorbatykh ◽

A. S. Gaytan ◽

P. A. Semin ◽

V. V. Kobozev

Keyword(s):

Surgical Treatment ◽

Intracranial Pressure ◽

Female Patient ◽

Arachnoid Cyst ◽

Clinical Course ◽

Operative Management ◽

Middle Cranial Fossa ◽

Raised Intracranial Pressure ◽

Cranial Fossa ◽

Aggressive Clinical Course

In this publication we report a case of atypical, aggressive clinical course of arachnoid cyst in 19-year old female patient, which caused raised intracranial pressure and disruption of bony structures of the middle cranial fossa and the orbit. It also describes peculiarities of operative management and results of surgical treatment of this patient.

Download Full-text

Immunocytochemical characteristics of submucosal uterine myomas

Vojnosanitetski pregled ◽

10.2298/vsp1012977m ◽

2010 ◽

Vol 67 (12) ◽

pp. 977-982 ◽

Cited By ~ 1

Author(s):

Aleksandra Mladenovic-Mihailovic ◽

Zorica Mladenovic-Bogdanovic ◽

Predrag Mitrovic ◽

Irena Tanaskovic ◽

Slavica Usaj-Knezevic ◽

...

Keyword(s):

Smooth Muscle ◽

Connective Tissue ◽

Smooth Muscle Cells ◽

Smooth Muscle Actin ◽

Muscle Cells ◽

Synthetic Activity ◽

Benign Tumors ◽

Paraffin Sections ◽

Weak Reaction ◽

Synthetic Phenotype

Background/Aim. Myomas of the uterus, the most common benign tumors, have been studied for decades from the aspects of different basic and clinical disciplines. Despite this fact, their pathogenesis is still poorly understood. The aim of this study was to determine immunocytochemical characteristics of smooth muscle cells and connective tissue components of submucosal myomas of the uterus. Method. During the course of this study, 25 samples of submucosal myomas of the uterus were analyzed, all of them obtained during the surgery, after abdominal histerctomy by Aldridge. The samples were fixed in 4% formalin and embedded in paraffin. Sections of 5 ?m thickness were stained immunocytochemically using the DAKO LSAB+/HRP technique to identify ?- smooth muscle actin (?-SMA), vimentin, desmin, CD34, CD45, CD68 and PCNA (DAKO specification). Results. Our results suggest that submucosal myomas of the uterus are build-up of smooth muscle cells which are immunoreactive to ?-SMA and desmin, but also to a certain number of smooth muscle cells which are immunoreactive to ?-SMA and vimentin. Some of vimentin-immunoreactive cells also show an immunoreactivity of PCNA. In the build-up of connective stroma CD34-immunoreactive fibroblasts and neovascular formations are also present. By examining the distribution of CD45 antigen, at all the analyzed samples we observed a weak reaction. Conclusion. Submucosal myomas of the uterus are made-up of smooth muscle cells of the highly differentiated contractile phenotype (?-SMA- and desminimmunoreactivity), as well as smooth muscle cell of the synthetic phenotype which proliferate (?-SMA-, vimentin- and PCNA-immunoreactivity). In submucosal myoma of the uterus there is a significant presence of connective tissue as a result of synthetic activity of fibroblasts, which clearly differ in their immunocytochemical characteristics from smooth muscle cells of the synthetic phenotype.

Download Full-text

Total and visceral adipose-tissue volumes derived from measurements with computed tomography in adult men and women: predictive equations

American Journal of Clinical Nutrition ◽

10.1093/ajcn/48.6.1351 ◽

1988 ◽

Vol 48 (6) ◽

pp. 1351-1361 ◽

Cited By ~ 481

Author(s):

H Kvist ◽

B Chowdhury ◽

U Grangård ◽

U Tylén ◽

L Sjöström

Keyword(s):

Computed Tomography ◽

Adipose Tissue ◽

Visceral Adipose Tissue ◽

Predictive Equations ◽

Men And Women ◽

Adult Men ◽

Visceral Adipose

Download Full-text

Abdominal subcutaneous adipose tissue cellularity in men and women

International Journal of Obesity ◽

10.1038/ijo.2017.148 ◽

2017 ◽

Vol 41 (10) ◽

pp. 1564-1569 ◽

Cited By ~ 14

Author(s):

D P Andersson ◽

E Arner ◽

D E Hogling ◽

M Rydén ◽

P Arner

Keyword(s):

Adipose Tissue ◽

Subcutaneous Adipose Tissue ◽

Men And Women ◽

Subcutaneous Adipose

Download Full-text

Abstract 047: Trajectories of Maintaining Recommended Amounts of Physical Activity in Young Adulthood and Associations with Abdominal Adiposity in Middle Age: The Cardia Study

Circulation ◽

10.1161/circ.127.suppl_12.a047 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Christina M Shay ◽

Laura Colangelo ◽

Mercedes R Carnethon ◽

Kiang Liu ◽

Norrina B Allen ◽

...

Keyword(s):

Physical Activity ◽

Adipose Tissue ◽

Young Adulthood ◽

Middle Age ◽

White Men ◽

Abdominal Adiposity ◽

Men And Women ◽

Highly Active ◽

Active Adults ◽

Modest Activity

Background: Greater abdominal adiposity is associated with insulin resistance and obesity-related vascular disease. Physical activity (PA) is inversely associated with abdominal adiposity yet associations between trends in adherence to PA recommendations through young adulthood and abdominal adiposity in middle age is unclear. Objective: To identify common trajectories of maintaining recommended levels of PA through young adulthood and to examine associations between trajectories and abdominal adiposity at middle age. Methods: The Coronary Artery Risk Development in Young Adults (CARDIA) study is a population-based, prospective, observational study of black and white men and women. PA was assessed at 8 exams across 25 years of follow-up. PA trajectories were identified by group-based modeling (PROC TRAJ) based on likelihood of maintaining recommended PA levels across exams. Visceral, subcutaneous, and abdominal intermuscular adipose tissue volumes (cm3) were assessed by computed tomography at the year 25 exam (43-55 yrs, n=3180). Results: Four major PA trajectories were identified: highly active (27.3%), declining activity (18.2%), modestly active (20.7%) and always sedentary (33.8%). Abdominal adipose tissue volumes by PA trajectory, race, and sex are displayed in Figure 1. Among white men and women, abdominal adiposity was lowest in always active adults and highest in those always sedentary; higher abdominal adiposity was observed with declining activity compared to modest activity. In black women, highest levels of abdominal adiposity were observed with declining activity. Black men exhibited no differences in abdominal adiposity across PA trajectory groups. Conclusions: Maintaining recommended physical activity levels through young adulthood is associated with lower abdominal adiposity at middle age. Highly active adults who exhibit declining physical activity towards middle age exhibit higher abdominal adiposity compared to adults with consistent modest activity throughout adulthood.

Download Full-text

Clinical and epidemiological features of manifestations of Wolf – Parkinson – White syndrome in men of draft age with increased dysplastic stigmatization

Vestnik of Russian military medical Academy ◽

10.17816/brmma50523 ◽

2020 ◽

Vol 22 (3) ◽

pp. 8-11

Author(s):

K. S. Shulenin ◽

D. V. Cherkashin ◽

G. G. Kutelev ◽

V. A. Kachnov ◽

V. S. Ivanov ◽

...

Keyword(s):

Retrospective Study ◽

Mitral Valve ◽

Connective Tissue ◽

Clinical Course ◽

Lower Number ◽

White Syndrome ◽

Epidemiological Features ◽

Flat Feet ◽

High Incidence ◽

Constitution Type

Abstract. Clinical and epidemiological and electrocardiographic features of Wolf Parkinson White syndrome in men of military age were studied. The study was a retrospective study with a solid sample of patients. Of the 1,9056 men residents of St. Petersburg between the ages of 18 and 27, Wolf-Parkinson-White syndrome was identified in 107 (0,56%) people. The disease was asymptomatic in 38 (35,5%) patients. All identified individuals with Wolf Parkinson White syndrome, in addition to asthenic Constitution type, which was observed in 68,2% of cases, were assessed for signs of systemic connective tissue involvement. It was found that flat feet, scoliosis or kyphosis, myopia, as well as mitral valve prolapse and abnormally located chords in the left ventricle of the heart are detected in almost every second man of military age. Due to the inability to assess the presence of all signs of systemic connective tissue involvement, the isolation of specific variants of dysplastic phenotypes in patients with Wolf Parkinson White syndrome was not performed. It was found that in the presence of increased dysplastic stigmatization, the clinical course of Wolf Parkinson White syndrome is characterized by a lower number of asymptomatic cases (6,3 and 16,7%, respectively; p0,05), an increase in the frequency of paroxysmal tachyarrhythmias (81,5 and 63,1%, respectively; p0,05) and a high incidence of vegetative-vascular disorders (82,8 and 15,4%, respectively; p0,05).

Download Full-text