scholarly journals Hypopituitarism as a result of recurrent craniopharyngioma

2020 ◽  
Vol 11 (4) ◽  
pp. 74-77
Author(s):  
Z. R. Alimetova ◽  
A. I. Galieva
Keyword(s):  
Surgical Treatment ◽  
Postoperative Period ◽  
Clinical Observation ◽  
Dynamic Monitoring ◽  
Endoscopic Endonasal

The article presents a clinical observation of a patient with a complication of endoscopic endonasal removal of craniopharyngioma in the form of hypopituitarism. The peculiarity of this case is a recurrent course of craniopharyngioma, due to which the patient was twice subjected to surgical treatment. This demonstrates the necessity of dynamic monitoring of the patient in the postoperative period.

scholarly journals Predictive value of MMP-2, MMP-9, TIMP-1 in surgical treatment of localized renal cell cancer

2021 ◽  
Vol 8 (2) ◽  
pp. 62-74
Author(s):  
A. I. Tarasenko ◽  
A. N. Rossolovskiy ◽  
O. L. Berezinets ◽  
D. A. Durnov ◽  
E. B. Popyhova ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Blood Serum ◽  
Sensitivity And Specificity ◽  
Postoperative Period ◽  
Radical Nephrectomy ◽  
Solid Phase ◽  
Cell Cancer ◽  
Individual Characteristics ◽  
Dynamic Monitoring ◽  
Design Bureau

Purpose of the study. To determine the association of individual biomolecular markers of oncogenesis MMP‑2, MMP‑9 and the inhibitor of metalloproteinases TIMP‑1 with the risk of tumor invasion and metastasis in the early and late postoperative period in various types of surgical treatment of RCC.Materials and methods. The study prospectively included medical data of 60 patients with kidney cancer with T1-3N0 M0 who received surgical treatment at the Urology Clinic of the S.R.Mirotvortsev Design Bureau of the SSMU from 2016 to 2019. The patients were divided into 3 groups: 1st group included 20 patients who underwent kidney resection for elective indications, with tumors of the renal parenchyma; 2nd group – 20 patients who underwent radical nephrectomy by laparoscopic approach; Group 3-20 patients who underwent radical nephrectomy with lumbotomy access. All patients being in the early (7-10th day) and long-term postoperative period (after 1 and 2 years) by solid-phase ELISA, on a StatFax 4200 analyzer using eBiosence and Cloud-Clone Corp reagent kits, a study was made on the basis of the concentration in the blood serum of markers of oncogenesis MMP‑2, MMP‑9 and TIMP‑1 metalloproteinase inhibitor.Results. In all groups of patients with RCC, an initial increase in the concentration of MMP‑9 was revealed compared to the control (p≤0.05). According to the results of the ROC analysis, this indicator has a high specificity and sensitivity in terms of predicting RCC at the preoperative stage. The highest sensitivity and specificity for detecting tumor progression was demonstrated by matrix metalloproteinases: MMP‑2 – sensitivity 96 %, specificity 67 % (cut-off point 357.5 pg/ml) and MMP‑9 – sensitivity 87.5 % and specificity 62 % (cut-off point 958 ng/ml). At the same time, TIMP‑1 showed less significant indicators – sensitivity and specificity (74 % and 60 %, respectively) with a cut-off point of 0.49 ng/ml.Conclusion. Serum MMP‑2 and MMP‑9 are a marker of a poor prognosis for the progression of RCC. Elevated levels of MMP‑9 in the blood serum of RCC patients before and after various types of surgical treatment reflect the individual characteristics of the patient’s body and the tumor process. Dynamic monitoring of the level of markers of oncogenesis in patients with RCC allows a personalized approach to the choice of the scope and method of surgical treatment of RCC.

scholarly journals Telescoping with Multiple Revolution Cranial Osteotomies in Patients with Simple Craniosynostosis

2020 ◽  
Author(s):  
Diego José Caycedo ◽  
Marcela Cabal Castro ◽  
Luís Fernando Santacruz
Keyword(s):  
Surgical Treatment ◽  
3D Reconstruction ◽  
Postoperative Period ◽  
Clinical Observation ◽  
Case Series ◽  
Cranial Growth ◽  
Clinical Complications ◽  
Case Series Study ◽  
Cranial Deformity ◽  
Series Study

Simple craniosynostosis is a cranial deformity that occurs secondary to a premature closure of one or more sutures, with a consequent alteration in cranial growth and cerebral expansion. The cranial alteration presents as flattening parallel to the compromised suture, with compensatory bulging in a perpendicular vector. The surgical treatment consists in cranial decompressions with suturectomies and simultaneous cranioplasties. Dynamic multiple revolution osteotomies allow the design of bone flaps that can help with decompression and correct secondary deformities caused by the synostosis. This multicenter descriptive case series study assessed 52 patients (12 plagiocephaly, 29 scaphocephaly, 7 brachycephaly and 4 trigonocephaly) operated in Cali, Colombia. In each case, suturectomy and telescoping with multiple revolution cranial osteotomies were designed to correct each particular deformity. No clinical complications were observed in the postoperative period (1, 90, and 180 days), and excellent outcomes with no re ossification of sutures and maintenance of the cranioplasty, based on clinical observation and findings in the 3D reconstruction scans.

scholarly journals The use of orthotics in a patient with congenital backbone deformation after surgical treatment

2018 ◽  
Vol 6 (4) ◽  
pp. 103-109
Author(s):  
Vladislav V. Murashko ◽  
Dmitry N. Kokushin ◽  
Sergei V. Vissarionov ◽  
Grigoriy A. Lein ◽  
Ivan V. Pavlov ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Spinal Deformity ◽  
Postoperative Period ◽  
Clinical Observation ◽  
Surgical Intervention ◽  
Congenital Scoliosis ◽  
Congenital Deformity ◽  
Congenital Deformities ◽  
Thoracic And Lumbar Spine ◽  
Congenital Spinal Deformity

Introduction. New questions of indications and methods of surgical treatment of children with congenital spinal deformity are covered in detail. However, straightening deformed segment of the spine and fixing with metal construction is not sufficient, and conditions for its retention and prevention of migration must be created. The expediency of the study is relevant because of lack of systematic review of the results of orthotic support as complex treatment of this group of patients, both in Russia and abroad. The problems faced by vertebral surgeons are the following: the tendency of deformation relapse as the child grows, tendency of deformation of unfixed (lower and upper) segments of the vertebral column. Clinical case. For observation, we selected an 11-year-old patient. The diagnosis was congenital scoliosis on posterolateral hemivertebra Th4, dysplastic course of congenital spinal deformity. The surgical treatment performed was extirpation of hemivertebra Th4(S) and the correction of local congenital deformity with multicore corrective system in combination with bone grafting. We achieved complete correction of congenital local curve at the level of the posterior lateral hemivertebra and reduction of compensatory curves in the thoracic and lumbar spine. In the postoperative period, the patient was provided with corrective brace, with the aim of influencing on the compensatory curve. Discussion. This clinical observation aimed to determine the different approaches to treatment of children with congenital deformities of the thoracic spine, which consists of surgical correction of local congenital curvature curve with subsequent correction of compensatory curves by using a correcting brace. Conclusion. As a result of the surgical intervention, correction of congenital spinal deformity was achieved, and the use of a corrective brace in the postoperative period allowed the correction of compensatory curves and maintained the achieved result until the end of the patient’s growth.

Clinical analysis and efficacy of bimanual surgical treatment of retinal detachment in severe forms of proliferative diabetic retinopathy with preoperative preparation with anti-VEGF drugs in combination with the use of the Ngenuity ALCON 3D imaging system

2021 ◽  
pp. 195-198
Author(s):  
D.V. Chernykh ◽  
Keyword(s):  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Surgical Treatment ◽  
Retinal Detachment ◽  
Postoperative Period ◽  
3D Imaging ◽  
Imaging System ◽  
3D Visualization ◽  
Preoperative Preparation ◽  
Anti Vegf

The purpose of the study was to evaluate the effectiveness of bimanual surgery with anti-VEGF preparation of patients with severe forms of PDR complicated by traction retinal detachment, with intraoperative use of 3D visualization. Material and methods. Operated on 18 patients with a diagnosis of PDR complicated by traction retinal detachment. Of these, there were 7 patients with type 1 diabetes, type 2 diabetes. There were 5 men and 13 women. The average age was 58 + -2 years. All patients underwent a three-port vitrectomy, using an additional light source, with preoperative preparation with anti-VEGF drugs, using bimanual technique and 3D visualization, using air tamponade. Results and its discussion. As a result of the study, it was found that the visual acuity before the treatment was 0.03 [0.01; 0.1], and 4-6 months after the surgical treatment, 0.3 [0.15; 0.5]. The performed statistical analysis made it possible to establish a statistically significant increase in visual acuity 4-6 months after the treatment. (p = 0.001) Achieved complete anatomical retinal fit. With increased visual acuity. There were 5 complications in the postoperative period. Recurrent hemophthalmos was diagnosed in 3 people, which required repeated surgical intervention. In 2 patients in the postoperative period, DMO developed, which required IVI biodegradable dexamethasone implant. Conclusion. Bimanual, surgical treatment of traction retinal detachments, in severe forms of PDLP, with preoperative preparation with anti-VEGF drugs, and the use of the Ngenuity ALCON 3D imaging system, is one of the effective methods of treatment in this group of patients, and is aimed at reducing both intra and postoperative complications. Key words: рroliferative diabetic retinopathy, vitrectomy, 3D imaging, bimanual surgery, anti-VEGF drugs.

scholarly journals Comparative analysis of the quality of life of children with congenital scoliosis after surgical treatment: Extirpation of the hemivertebra from dorsal and combined access

2021 ◽  
Vol 9 (2) ◽  
pp. 153-162
Author(s):  
Dmitry N. Kokushin ◽  
Michael A. Khardikov ◽  
Sergey V. Vissarionov ◽  
Vera V. Sokolova ◽  
Nikita O. Khusainov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Surgical Treatment ◽  
Postoperative Period ◽  
Deformity Correction ◽  
Lumbar Vertebra ◽  
Congenital Scoliosis ◽  
Congenital Deformity ◽  
Subsequent Increase ◽  
Level Of Satisfaction

BACKGROUND: Congenital scoliosis with disorders of the formation of the vertebrae is the most common cause of pronounced deformities of the spine in early childhood. This pathology can be treated surgically using various techniques that differ in invasiveness, severity of the condition in the postoperative period, achieved result of deformity correction, and nature of the long-term prognosis. Numerous studies have assessed the quality of life of patients who underwent surgery for acquired deformities, trauma, and degenerative and neoplastic diseases of the spine in adults. However, features of the childs quality of life following surgical technique for congenital scoliosis have not been sufficiently studied. AIM: This study aimed to compare the quality of life of children with congenital scoliosis of the thoracolumbar localization after extirpation of the hemivertebra from the dorsal and combined approaches. MATERIALS AND METHODS: An intergroup prospective analysis of the results of a survey of 60 patients with congenital deformity of the spine against the background of an isolated violation of the formation of the thoracic or lumbar vertebra was carried out. Patients underwent standard surgical treatment. Patients were divided into two groups according to the surgical approach to the abnormal vertebral body: dorsal group (n = 28) and combined group (n = 32). The average age of the patients was 75 (minmax, 26196) months. The follow-up period was 18 months after surgery. To assess the quality of life, a specialized Russian version of the PedsQL v4.0 questionnaire and a modified visual analog scale were used. RESULTS: After surgical treatment of congenital spinal deformity, quality of life indicators decreased more than two times than the results of a preoperative survey. At 18 months postoperatively, the physical activity and psychoemotional state were restored to the preoperative level, while patients of the combined group had a higher satisfaction score on the quality of life (p 0.05). CONCLUSIONS: The combined approach provides the best correction of congenital deformity of the spine and allows maintaining of the achieved result throughout the observation period. In the early postoperative period, the combined group demonstrated a significant decrease in the level of satisfaction with the quality of life, while the pain syndrome was higher than that in the dorsal group. Dynamic observation revealed the leveling of these differences and a subsequent increase in the level of satisfaction with the quality of life of these patients.

scholarly journals Repeated fracture of the femoral neck. Tactics of treatment. Clinical observation

2015 ◽  
Vol 3 (2) ◽  
pp. 48-51
Author(s):  
Pavel Igorevich Bortulev ◽  
Yaroslav Nikolaevich Proshchenko ◽  
Anatoliy Vasilievich Ovsyankin ◽  
Alexey Polikarpovich Drozdetskiy ◽  
Oksana Vyacheslavovna Bortuleva
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Femoral Neck ◽  
Clinical Observation ◽  
Multiple Fractures

The article presents a case report of surgical treatment of multiple fractures of the femoral neck in 15-year old child.

scholarly journals Possibilities of minimally invasive treatments of hemorrhoidal disease

2018 ◽  
pp. 77-82 ◽  
Author(s):  
M. V. Abritsova
Keyword(s):  
Surgical Treatment ◽  
Minimally Invasive ◽  
Postoperative Period ◽  
Harmonic Scalpel ◽  
Hemorrhoidal Disease ◽  
Single Center ◽  
Narcotic Analgesics ◽  
Group I ◽  
Minimally Invasive Treatments ◽  
Observation Period

The article presents the results of surgical treatment of patients with stages III to IV hemorrhoids followed by an observation period of 45 days, which is designed to improve the results of surgical treatment of this category of patients. The surgical treatment methods included doppler-guided transanal hemorrhoiddearterialization with mucopexy (DDM) (Group I) and harmonic scalpel hemorrhoidectomy (HSH) (Group II). Operated patients underwent all necessary examinations according to the “per protocol” principle. Study Design: single-center controlled randomized prospective. The effectiveness of DDM was comparable to that of hemorrhoidectomy (HE), which made it possible to significantly reduce the duration of the operation (DDM 17.9 ± 6.1 min, GE 34.5 ± 10.1 min (p <0.01) ), reduce the level of pain in the postoperative period (DDM an average of 2.5 points, HE 4.8 points (p <0.01)), reduce the frequency of narcotic analgesics (DDM an average of 1.3 doses, HE an average of 6.1 doses (p <0.01)) and shorten the period of disability (DDM 14.4 ± 5.2 days, HE 30.3 ± 5.4 days (p <0.01)) patients with stages III to IV disease.

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