scholarly journals Stratification of Individual Symptoms of Contact Lens–Associated Dry Eye Using the iPhone App DryEyeRhythm: Crowdsourced Cross-Sectional Study (Preprint)

2020 ◽  
Author(s):  
Takenori Inomata ◽  
Masahiro Nakamura ◽  
Masao Iwagami ◽  
Akie Midorikawa-Inomata ◽  
Jaemyoung Sung ◽  
...  
Keyword(s):  
Risk Factors ◽  
Personalized Medicine ◽  
Dry Eye ◽  
Contact Lens ◽  
Contact Lenses ◽  
Cross Sectional Study ◽  
Subjective Symptoms ◽  
Sectional Study ◽  
Odds Ratios ◽  
Cross Sectional

BACKGROUND Discontinuation of contact lens use is mainly caused by contact lens–associated dry eye. It is crucial to delineate contact lens–associated dry eye's multifaceted nature to tailor treatment to each patient’s individual needs for future personalized medicine. OBJECTIVE This paper aims to quantify and stratify individual subjective symptoms of contact lens–associated dry eye and clarify its risk factors for future personalized medicine using the smartphone app DryEyeRhythm (Juntendo University). METHODS This cross-sectional study included iPhone (Apple Inc) users in Japan who downloaded DryEyeRhythm. DryEyeRhythm was used to collect medical big data related to contact lens–associated dry eye between November 2016 and January 2018. The main outcome measure was the incidence of contact lens–associated dry eye. Univariate and multivariate adjusted odds ratios of risk factors for contact lens–associated dry eye were determined by logistic regression analyses. The t-distributed Stochastic Neighbor Embedding algorithm was used to depict the stratification of subjective symptoms of contact lens–associated dry eye. RESULTS The records of 4454 individuals (median age 27.9 years, SD 12.6), including 2972 female participants (66.73%), who completed all surveys were included in this study. Among the included participants, 1844 (41.40%) were using contact lenses, and among those who used contact lenses, 1447 (78.47%) had contact lens–associated dry eye. Multivariate adjusted odds ratios of risk factors for contact lens–associated dry eye were as follows: younger age, 0.98 (95% CI 0.96-0.99); female sex, 1.53 (95% CI 1.05-2.24); hay fever, 1.38 (95% CI 1.10-1.74); mental illness other than depression or schizophrenia, 2.51 (95% CI 1.13-5.57); past diagnosis of dry eye, 2.21 (95% CI 1.63-2.99); extended screen exposure time >8 hours, 1.61 (95% CI 1.13-2.28); and smoking, 2.07 (95% CI 1.49-2.88). The t-distributed Stochastic Neighbor Embedding analysis visualized and stratified 14 groups based on the subjective symptoms of contact lens–associated dry eye. CONCLUSIONS This study identified and stratified individuals with contact lens–associated dry eye and its risk factors. Data on subjective symptoms of contact lens–associated dry eye could be used for prospective prevention of contact lens–associated dry eye progression.

scholarly journals Stratification of Individual Symptoms of Contact Lens–Associated Dry Eye Using the iPhone App DryEyeRhythm: Crowdsourced Cross-Sectional Study

10.2196/18996 ◽  
2020 ◽  
Vol 22 (6) ◽  
pp. e18996 ◽  
Author(s):  
Takenori Inomata ◽  
Masahiro Nakamura ◽  
Masao Iwagami ◽  
Akie Midorikawa-Inomata ◽  
Jaemyoung Sung ◽  
...  
Keyword(s):  
Risk Factors ◽  
Personalized Medicine ◽  
Dry Eye ◽  
Contact Lens ◽  
Contact Lenses ◽  
Cross Sectional Study ◽  
Subjective Symptoms ◽  
Sectional Study ◽  
Odds Ratios ◽  
Cross Sectional

Background Discontinuation of contact lens use is mainly caused by contact lens–associated dry eye. It is crucial to delineate contact lens–associated dry eye's multifaceted nature to tailor treatment to each patient’s individual needs for future personalized medicine. Objective This paper aims to quantify and stratify individual subjective symptoms of contact lens–associated dry eye and clarify its risk factors for future personalized medicine using the smartphone app DryEyeRhythm (Juntendo University). Methods This cross-sectional study included iPhone (Apple Inc) users in Japan who downloaded DryEyeRhythm. DryEyeRhythm was used to collect medical big data related to contact lens–associated dry eye between November 2016 and January 2018. The main outcome measure was the incidence of contact lens–associated dry eye. Univariate and multivariate adjusted odds ratios of risk factors for contact lens–associated dry eye were determined by logistic regression analyses. The t-distributed Stochastic Neighbor Embedding algorithm was used to depict the stratification of subjective symptoms of contact lens–associated dry eye. Results The records of 4454 individuals (median age 27.9 years, SD 12.6), including 2972 female participants (66.73%), who completed all surveys were included in this study. Among the included participants, 1844 (41.40%) were using contact lenses, and among those who used contact lenses, 1447 (78.47%) had contact lens–associated dry eye. Multivariate adjusted odds ratios of risk factors for contact lens–associated dry eye were as follows: younger age, 0.98 (95% CI 0.96-0.99); female sex, 1.53 (95% CI 1.05-2.24); hay fever, 1.38 (95% CI 1.10-1.74); mental illness other than depression or schizophrenia, 2.51 (95% CI 1.13-5.57); past diagnosis of dry eye, 2.21 (95% CI 1.63-2.99); extended screen exposure time >8 hours, 1.61 (95% CI 1.13-2.28); and smoking, 2.07 (95% CI 1.49-2.88). The t-distributed Stochastic Neighbor Embedding analysis visualized and stratified 14 groups based on the subjective symptoms of contact lens–associated dry eye. Conclusions This study identified and stratified individuals with contact lens–associated dry eye and its risk factors. Data on subjective symptoms of contact lens–associated dry eye could be used for prospective prevention of contact lens–associated dry eye progression.

scholarly journals The Prevalence and Risk Factors for Symptomatic Dry Eye in Adults in Riyadh, Saudi Arabia

2021 ◽  
Vol 15 (1) ◽  
pp. 277-282
Author(s):  
Anas Abdulaziz Almujalli ◽  
Abdulaziz Abdullah Almatrafi ◽  
Anas Abdullah Aldael ◽  
Talal Waleed Aljudi ◽  
Bahaa-Eldin Hasan Abdulhalim
Keyword(s):  
Risk Factors ◽  
Saudi Arabia ◽  
Dry Eye ◽  
Skin Diseases ◽  
Contact Lenses ◽  
Female Gender ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Associated Risk Factors ◽  
Structured Questionnaire

Objectives: The objective of this study is to estimate the prevalence of symptomatic suspected dry eye, diagnosed dry eye syndrome (DES), and associated risk factors; in Riyadh, Saudi Arabia. Methods: A cross-sectional study of 654 participants was employed using a self-administered semi-structured questionnaire that included demographic characteristics like age, gender, and risk factors (smoking, using contact lenses, chronic comorbidities, etc.). Results: There were 266 (40.7%) previously diagnosed DES participants and 388 (59.3%) non-diagnosed DES, of which 497 were female and 157 were male. Females had a significantly higher rate of diagnosed DES than males (p<0.001), with a significant increase in the rate of DES diagnosis with age (p<0.001). There was also a significant increase in DES in participants with diabetes mellitus, allergic eye, thyroid eye, and skin diseases, as well as having undergone laser surgery or using contact lenses. There was no significant increase in DES in cases of smoking, daily use of electronic devices, or duration of sleep. Conclusion: The prevalence of dry eye among adults in Riyadh was 46.6%, with the most important risk factors being female gender, increasing age, Lasik refractive surgery, skin disease around the eye, and thyroid eye disease.

scholarly journals Systemic risk factors of dry eye disease subtypes: A New Zealand cross-sectional study

2020 ◽  
Vol 18 (3) ◽  
pp. 374-380
Author(s):  
Michael T.M. Wang ◽  
Maria Vidal-Rohr ◽  
Alex Muntz ◽  
William K. Diprose ◽  
Susan E. Ormonde ◽  
...  
Keyword(s):  
Risk Factors ◽  
New Zealand ◽  
Dry Eye ◽  
Systemic Risk ◽  
Cross Sectional Study ◽  
Eye Disease ◽  
Sectional Study ◽  
Cross Sectional ◽  
Disease Subtypes ◽  
Systemic Risk Factors

Demographic and lifestyle risk factors of dry eye disease subtypes: A cross-sectional study

2021 ◽  
Vol 21 ◽  
pp. 58-63
Author(s):  
James S. Wolffsohn ◽  
Michael T.M. Wang ◽  
Maria Vidal-Rohr ◽  
Francesco Menduni ◽  
Sandeep Dhallu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dry Eye ◽  
Cross Sectional Study ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lifestyle Risk Factors ◽  
Disease Subtypes ◽  
Lifestyle Risk

scholarly journals The prevalence, severity, and risk factors for dry eye disease in Dubai – a cross sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sarah Alkabbani ◽  
Lakshmanan Jeyaseelan ◽  
Anupama P. Rao ◽  
Sandeep P. Thakur ◽  
Pramod T. Warhekar
Keyword(s):  
United Arab Emirates ◽  
Dry Eye ◽  
Online Survey ◽  
Contact Lenses ◽  
Cross Sectional Study ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dry Eyes

Abstract Background The prevalence of dry eye disease is increasing globally and requires the attention of healthcare professionals as it worsens patients’ quality of life. No published studies on the epidemiology of dry eyes have been found in Dubai. Purpose To describe the epidemiology, prevalence, severity, and associated factors of dry eyes in Dubai, United Arab Emirates, in 2019. Methods This was an analytical, cross-sectional, survey-based study. An online survey was distributed by email to Mohammed Bin Rashid University students, staff, and faculty and to the staff at Mediclinic City and Parkview Hospitals in Dubai, United Arab Emirates, from April–June 2019. The survey included demographic questions and the Ocular Surface Disease Index (OSDI). Results The survey was completed by 452 participants; the majority were females (288/452; 63.7 %). The prevalence of dry eyes in Dubai was estimated to be 62.6 % (283/452), with severely dry eyes being the most prevalent (119/283; 42 %). Females, high daily screen time (> 6 h), and the use of contact lenses were found to be associated with dry eyes (P-value < 0.05, 95 % confidence interval). Age was found to be negatively correlated with prevalence of dry eyes. Exposure to smoking/shisha, history of eye injury/surgery, and nationality were not associated with dry eyes. Conclusions This is the first cross-sectional study to investigate the prevalence of dry eyes in Dubai (62.6 %). The majority of participants had severe dry eyes symptoms. Severely dry eyes were more common among females and users of contact lenses.

PRRSV: Risikofaktoren und Herdenprävalenz in Deutschland

2019 ◽  
Vol 47 (02) ◽  
pp. 132-132
Author(s):  
Sebastian Ganz
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Respiratory Syndrome Virus ◽  
Sectional Study ◽  
Cross Sectional ◽  
Klinische Symptome

Nathues C, Janssen E, Duengelhoef A et al. Cross-sectional study on risk factors for Porcine Reproductive and Respiratory Syndrome virus sow herd instability in German breeding herds. Acta Vet Scand 2018; 60 (1): 1–8 In mit PRRSV (Porcine Reproductive and Respiratory Syndrom Virus) infizierten Schweinebeständen zeigen die Tiere oftmals ernsthafte klinische Symptome. Die Schwere der Symptomatik hängt von der Virulenz der jeweiligen Virusstämme ab. Deshalb ist die Impfung gegen diesen Erreger sinnvoll und wird empfohlen, auch wenn sie nicht immer klinische Fälle verhindert bzw. das Virus vollends eliminiert. Aufgrund dessen rückt die Prävention durch Verbesserung der innerbetrieblichen Abläufe zunehmend in den Fokus. Um solche Maßnahmen erfolgreich etablieren zu können, ist es wichtig, den epidemiologischen Status der Herde und mögliche Risikofaktoren zu kennen. Ziel der Studie war deshalb, die Prävalenz der Infektion in Sauenbetrieben in Norddeutschland zu eruieren und verschiedene Arbeitsabläufe hinsichtlich des Risikos der Erregerverbreitung zu untersuchen.

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