Literature Review on the Efficacy of Laser and Pharmacotherapy (Preprint)

2021 ◽  
Author(s):  
Mauricio Jonathon Portillo ◽  
Joel Banez
Keyword(s):  
Literature Review ◽  
Adverse Effects ◽  
Skin Disease ◽  
Clinical Presentation ◽  
Definitive Treatment ◽  
Adrenergic Agonists ◽  
Inflammatory Skin Disease ◽  
Therapy Options ◽  
Target Characteristic ◽  
New Literature

UNSTRUCTURED Rosacea is a chronic inflammatory skin disease that is classified into 4 subtypes depending on the clinical presentation. There is no definitive treatment but many options are available to target characteristic symptoms. Laser therapy is increasingly becoming used to treat erythema and telangiectasias in rosacea patients. New literature is demonstrating that a combination of alpha2-adrenergic agonists may have greater efficacy than laser or pharmacotherapy alone. This review looks to compares therapy options available based on efficacy, relapse and adverse effects

scholarly journals Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis

Medicines ◽  
2019 ◽  
Vol 6 (4) ◽  
pp. 97 ◽  
Author(s):  
Christina D. Kwon ◽  
Raveena Khanna ◽  
Kyle A. Williams ◽  
Madan M. Kwatra ◽  
Shawn G. Kwatra
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Skin Disease ◽  
Clinical Presentation ◽  
Diagnostic Evaluation ◽  
Evidence Based ◽  
Inflammatory Skin Disease ◽  
Prurigo Nodularis ◽  
Principal Roles ◽  
Standardized Diagnostic

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in the pathogenesis of PN. There are several associated etiologic factors thought to be associated with PN, including dermatoses, systemic, infectious, psychiatric, and neurologic conditions. We conducted a systematic literature review to evaluate the clinical presentation, diagnosis, and etiologic factors of PN. In this review, we discuss common differential diagnoses of PN and recommend an evidence-based, standardized diagnostic evaluation for those with suspected PN.

Pityriasis rosea-like drug eruption due to bupropion

2014 ◽  
Vol 33 (12) ◽  
pp. 1294-1296 ◽  
Author(s):  
M. Polat ◽  
Ö. Uzun ◽  
İ. Örs ◽  
Ç. Boran
Keyword(s):  
Skin Disease ◽  
Drug Eruption ◽  
Clinical Case ◽  
Clinical Presentation ◽  
Common Disease ◽  
Hypersensitivity Reactions ◽  
Inflammatory Skin Disease ◽  
Pityriasis Rosea ◽  
Skin Tension ◽  
Scaly Skin

Pityriasis rosea (PR) is a common, acute, and self-limited inflammatory skin disease. The typical clinical presentation includes the appearance of a primary “herald” patch followed within days to weeks by the onset of secondary scaly skin eruptions distributed along the skin tension line in most cases. Although PR is a well-known and relatively common disease, its cause is still not completely understood. However, viral agents, autoimmunity, psychogenic status, and numerous drugs have been proposed as possible factors to PR. Bupropion is known to cause hypersensitivity reactions. We present a clinical case of PR eruption caused by the use of bupropion. To the best of our knowledge, this is the first published case of PR associated with bupropion use.

Pyoderma gangrenosum involving the foot. A case report

1999 ◽  
Vol 89 (3) ◽  
pp. 137-140 ◽  
Author(s):  
H Kashefsky ◽  
E Callahan ◽  
UC Ruder ◽  
PJ Grisafi ◽  
MP Dellacorte
Keyword(s):  
Ulcerative Colitis ◽  
Case Report ◽  
Pyoderma Gangrenosum ◽  
Skin Disease ◽  
Clinical Presentation ◽  
Disease Process ◽  
Differential Diagnoses ◽  
Inflammatory Skin Disease ◽  
Classic Case ◽  
Inflammatory Skin

Pyoderma gangrenosum is a rare and destructive inflammatory skin disease. The authors present a report of a patient with a classic case of pyoderma gangrenosum involving the foot. The diagnosis was made on the basis of clinical presentation and progression of the disease after differential diagnoses of common conditions were excluded. A brief overview of the disease process, its treatment, and its correlation with ulcerative colitis is provided.

scholarly journals Epithelial–Myoepithelial Carcinoma of the Lacrimal Sac and Literature Review of the Lacrimal System

2020 ◽  
Vol 11 ◽  
pp. 215265672092060
Author(s):  
Dhruv Sharma ◽  
Ashley Neiweem ◽  
Kyle Davis ◽  
Mark Prendes ◽  
Rao Chundury ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Presentation ◽  
Definitive Treatment ◽  
Malignant Neoplasms ◽  
Low Grade ◽  
Open Approach ◽  
Myoepithelial Carcinoma ◽  
Lacrimal Sac ◽  
Lacrimal System ◽  
Epithelial Myoepithelial Carcinoma

Background Epithelial–myoepithelial carcinomas make up less than 0.1% of head and neck malignancies and are regarded as rare, low-grade malignant neoplasms of the salivary gland. They are thought to arise from intercalated ducts with histopathology showing a classic biphasic morphology of an outer layer of myoepithelial cells and inner layer of epithelial cells. These tumors most commonly occur in the parotid gland; however, rare cases have also been described in the nasal cavity, nasopharynx, subglottis, base of tongue, and the lacrimal gland. Objective To describe the clinical presentation, surgical management, and histopathology of the first reported case of lacrimal sac epithelial–myoepithelial carcinoma. To conduct a literature review of this malignancy, which is present in the lacrimal system. Methods Case report (n = 1) and literature review. Results We report a case of a 72-year-old man presenting with epiphora and a lacrimal sac mass with intranasal extension on imaging and nasal endoscopy. A combined endoscopic endonasal and open approach provided successful definitive treatment for final pathologic diagnosis of epithelial–myoepithelial carcinoma of the lacrimal sac, with orbital reconstruction and lacrimal stenting providing good cosmetic and functional results. Conclusions After PubMed database search for any case series or reports of lacrimal system epithelial–myoepithelial carcinomas, we believe this is the first documented case originating from the lacrimal sac. Although the histopathology of this tumor is distinct, unusual location and clinical presentation may pose significant diagnostic difficulties.

scholarly journals From Emollients to Biologicals: Targeting Atopic Dermatitis

2021 ◽  
Vol 22 (19) ◽  
pp. 10381
Author(s):  
Lorenzo Salvati ◽  
Lorenzo Cosmi ◽  
Francesco Annunziato
Keyword(s):  
Atopic Dermatitis ◽  
Skin Disease ◽  
Clinical Presentation ◽  
Age Groups ◽  
Inflammatory Skin Disease ◽  
Clinical Phenotypes ◽  
Inflammatory Skin

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and significantly impacts patients’ lives, particularly in its severe forms. AD clinical presentation varies over the course of the disease, throughout different age groups, and across ethnicities. AD is characterized by a spectrum of clinical phenotypes as well as endotypes. Starting from the current description of AD pathogenesis, this review explores the rationale of approved AD therapies from emollients to biologicals and introduces novel promising drugs.

scholarly journals Treatment of Ipilimumab Induced Graves’ Disease in a Patient with Metastatic Melanoma

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Umal Azmat ◽  
David Liebner ◽  
Amy Joehlin-Price ◽  
Amit Agrawal ◽  
Fadi Nabhan
Keyword(s):  
Literature Review ◽  
Metastatic Melanoma ◽  
Clinical Presentation ◽  
Complete Response ◽  
Definitive Treatment ◽  
Graves Disease ◽  
Close Monitoring ◽  
Related Literature ◽  
Left Neck ◽  
Euthyroid Status

Objective. Thyroid disease has been reported among the endocrinopathies that can occur after treatment with ipilimumab. Graves’ disease, however, has been rarely reported with this medication. Here we report a case of Graves’ disease diagnosed after initiation of ipilimumab in a patient with melanoma.Methods. We present the clinical presentation and management course of this patient followed by a related literature review.Results. A 67-year-old male with metastatic melanoma was started on ipilimumab. He developed hyperthyroidism after two doses of ipilimumab. The cause of hyperthyroidism was determined to be Graves’ disease. Ipilimumab was held and the patient was started on methimazole with return to euthyroid status. Ipilimumab was resumed and the patient continued methimazole during the course of ipilimumab therapy, with controlled hyperthyroidism. Restaging studies following four cycles of ipilimumab showed complete response in the lungs, with residual melanoma in the neck. The patient then underwent total thyroidectomy and left neck dissection as a definitive treatment for both hyperthyroidism and residual melanoma.Conclusion. Graves’ disease can develop after starting ipilimumab and methimazole can be an effective treatment. For patients whose hyperthyroidism is well-controlled on methimazole, ipilimumab may be resumed with close monitoring.

Changes in CD44 isoform expression during inflammatory skin disease

1997 ◽  
Vol 22 (03) ◽  
pp. 128-133
Author(s):  
A.J. HARRIS ◽  
D. DEAN ◽  
S. BURGE ◽  
F. WOJNAROWSKA
Keyword(s):  
Skin Disease ◽  
Inflammatory Skin Disease ◽  
Inflammatory Skin ◽  
Isoform Expression

Bi-microbial Healthcare-Associate Endocarditis caused by Enterococcus faecalis and Burkholderia cepacia: A Case Report and literature review

2020 ◽  
Vol 02 ◽  
Author(s):  
Masood Ghori ◽  
Nadya O. Al Matrooshi ◽  
Samir Al Jabbari ◽  
Ahmed Bafadel ◽  
Gopal Bhatnagar
Keyword(s):  
Case Report ◽  
Infective Endocarditis ◽  
Literature Review ◽  
Enterococcus Faecalis ◽  
Surgical Management ◽  
Burkholderia Cepacia ◽  
Clinical Presentation ◽  
Complicated Course ◽  
Healthcare Associated ◽  
Echocardiographic Findings

: Infective Endocarditis (IE), a known complication of hemodialysis (HD), has recently been categorized as Healthcare-Associated Infective Endocarditis (HAIE). Single pathogen bacteremia is common, polymicrobial endocardial infection is rare in this cohort of the patients. We report a case of endocarditis caused by Enterococcus faecalis (E. faecalis) and Burkholderia cepacia (B. cepacia), a first ever reported combination of a usual and an unusual organism, respectively, in a patient on HD. Clinical presentation of the patient, its complicated course ,medical and surgical management ,along with microbial and echocardiographic findings is presented herein. The authors believe that presentation of this case of HAIE may benefit and contribute positively to cardiac science owing to the rare encounter of this organism as a pathogen in infective endocarditis and the difficulties in treating it.

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