scholarly journals PHYTOCHEMICAL STUDY ON THE ETHYLACETATE EXTRACT OF THE LEAVES OF Mesua ferrea LINN

2010 ◽  
Vol 8 (2) ◽  
pp. 242-244 ◽  
Author(s):  
S. M. Mizanur Rahman ◽  
Swati Shabnom ◽  
M. Abdul Quader ◽  
M. Amzad Hossain
Keyword(s):  
Spectral Analysis ◽  
Medicinal Plant ◽  
1H Nmr ◽  
Mass Spectroscopy ◽  
13C Nmr ◽  
Spectroscopic Techniques ◽  
Phytochemical Study

Furano-napthyl-hydroxy cyclohexyl type of compound was isolated first times in plant from the ethyl extracts of the leaves of Mesua ferrea. The structure of the compound has been established by the modern spectroscopic techniques such as UV, IR, 1H-NMR, 13C-NMR and mass spectroscopy and identified as 12, 13-furano-8-hydroxy napthyl-6-0-b-2',3',4',6' tetrahydroxy-5',5' dimethyl cyclohexyl ether.   Keywords: Mesua ferrea Linn; Euphorbiaceae; Medicinal plant; new compound; spectral analysis

Benzimidazole Derivatives as Potential Antimicrobial and Antiulcer Agents: A Mini Review

2019 ◽  
Vol 19 (16) ◽  
pp. 1292-1297 ◽  
Author(s):  
Ali Mohd Ganie ◽  
Ayaz Mahmood Dar ◽  
Fairooz Ahmad Khan ◽  
Bashir Ahmad Dar
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
1H Nmr ◽  
13C Nmr ◽  
Benzimidazole Derivatives ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Biological Screening ◽  
Elemental Analyses ◽  
Characterization Studies

:Here in we report the number of strategies for the synthesis of differently substituted benzimidazole derivatives. The protocols involved in the syntheses of these derivatives were one-pot or multi-component. The characterization studies of these derivatives were carried by using different spectroscopic techniques (1H NMR, 13C NMR and MS) and elemental analyses. The biological screening studies revealed that these benzimidazole derivatives show potential antibacterial as well as antifungal behavior. These benzimidazole derivatives not only depicted potential antiulcer properties but also showed moderate to good anticancer/cytotoxic behavior against different cancer cell lines.

Synthesis of urease inhibitory 2, 4-bis (4-cyanobenzyl)glycoluril using sandmeyer reaction and density functional theory investigation

2021 ◽  
Vol 18 ◽  
Author(s):  
Mirza Arfan Yawer ◽  
Shehar Bano ◽  
Muhammad Saleem ◽  
Affiefa Yawer ◽  
Riaz Hussain ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Density Functional Theory ◽  
1H Nmr ◽  
13C Nmr ◽  
Density Functional ◽  
Spectroscopic Techniques ◽  
Pure Compound ◽  
Functional Theory ◽  
Sandmeyer Reaction ◽  
Urease Enzyme

Aims: The aim of present research was to synthesize glycoluril derivative 2,4-Bis(4-cyanobenzyl)glycoluril through convergent scheme. Background: For this purpose Sandmeyer reaction procedure was employed for the synthesis of said compound. The structure of the pure compound was confirmed by using different spectroscopic techniques such as 1H-NMR, 13C-NMR and (HR-MS) Mass spectrometry. Objective: Convergent synthesis of 2,4-BIS (4-CYANOBENZYL)GLYCOLURIL USING SANDMEYER REACTION and urease inhibition study. Methods: The structure of the pure compound was confirmed by using different spectroscopic techniques such as 1H-NMR, 13C-NMR and (HR-MS) Mass spectrometry. The electronic properties of newly synthesized compound and thiourea were determined by using density functional theory. Results: Furthermore compound was evaluated against urease enzyme and was found to be potent inhibitors with IC50 value of 11.5 ± 1.50 µM when compared with standard inhibitor thiourea (IC50 = 21.0 ± 1.90 µM). Compound may serve as lead compound for the synthesis of new cyano based bambusuril in future with enhanced biological properties. Conclusion: We have synthesized a new glycoluril derivative 2,4-Bis(4-cyanobenzyl)glycoluril by the sandmeyer reaction. It has obtained in the form of light yellowish powder in good yield (96%). Glycoluril based macrocycles have been used in various fields. Starting from the 2,4-Bis(4-nitrobenzyl)glycoluril (already reported compound) which has undergone reduction (CH3OH,Pt/C) , diazotization (NaNO2/HCl), cyanation (CuCl/KCN) respectively in order to synthesize the desired new glycoluril derivative. The obtained product will be used as a building block for the synthesis of the cyano based bambusuril marcocycle in future. The yield of the obtained product has been monitored by using different amount of cyanating reagent but the best results shown by the use of 4 mmol of CuCl/KCN. KCN with CuCl assisted the conversion of diazo group into cyano group with enhanced yield when used in excess amount. It act as a catalyst. Solubility characteristic of 2,4-Bis(4-cyanobenzyl)glycoluril has determined also in different organic solvents. 1H NMR technique proved to be very helpful for the structure determination of our desired product. Benzylic protons give signals at 7.5 ppm and 7.8 ppm respectively. The downfield peaks confirm about the presence of CN group near the benzylic protons. Methine protons show signal at 5.2 ppm which ensures about the basic skeleton of glycoluril. Ureidyl protons also confirm the synthesis of the heterocyclic 2,4-Bis(4-cyanobenzyl)glycoluril compound. The negative and positive electrostatic potential sites, molecular descriptors, and charge density distribution of frontier molecular orbitals are revealing that 4a with promising sites for electrophilic and nucleophilic attacks would result to enhance the urease inhbition which is in good agreement with the experimental data.

scholarly journals Complete 1H-NMR and 13C-NMR spectral analysis of the pairs of 20(S) and 20(R) ginsenosides

2014 ◽  
Vol 38 (3) ◽  
pp. 194-202 ◽  
Author(s):  
Heejung Yang ◽  
Jeom Yong Kim ◽  
Sun Ok Kim ◽  
Young Hyo Yoo ◽  
Sang Hyun Sung
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr

scholarly journals 2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide

Molbank ◽  
10.3390/m1164 ◽  
2020 ◽  
Vol 2020 (4) ◽  
pp. M1164
Author(s):  
Mariia Nesterkina ◽  
Dmytro Barbalat ◽  
Ildar Rakipov ◽  
Iryna Kravchenko
Keyword(s):  
Mass Spectrometry ◽  
Valproic Acid ◽  
Spectral Analysis ◽  
Thermal Properties ◽  
1H Nmr ◽  
13C Nmr ◽  
Agent Based ◽  
Anticonvulsant Agent ◽  
Fab Mass Spectrometry

2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide was obtained in 80% yield via the Einhorn variation of the Schotten–Baumann method by (+)-camphor hydrazide condensation with valproic acid (VPA) chloride. The structure of the titled compound was verified by Raman, FTIR, 1H-NMR, and 13C-NMR spectral analysis along with FAB-mass spectrometry. Thermal properties of synthesized derivative were elucidated by DSC and its purity by HPLC. The compound was successfully tested as a potential anticonvulsant agent based on models of chemically- and electrically-induced seizures.

1,2,4-triazoles Clubbed Pyrimidine Compounds with Synthesis, Antimicrobial, Antituberculosis, Antimalarial, and Anti-protozoal Studies

2020 ◽  
Vol 17 ◽  
Author(s):  
Navin B. Patel ◽  
Hetal I. Soni ◽  
Rahul B. Parmar ◽  
Manuel J. Chan-Bacab ◽  
Gildardo Rivera
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr ◽  
Antifungal Agent ◽  
New Products ◽  
Antifungal Drugs ◽  
Bioactive Molecules ◽  
Mass Spectral Analysis ◽  
Mass Spectral

: Triazoles are famous as an antifungal agent. Itraconazole and fluconazole are the best examples of antifungal drugs available in the market, which consist an active triazole moiety. Pyrimidines are also bioactive molecules which shows multiple bioactivity. It’s an effort to synthesize pyrimidine clubbed triazole to enhance bioactivity. To synthesize new active pyrimidine clubbed triazole biomolecule and to evaluate these new products for better drug potential as antimicrobial, an-tituberculosis, antimalarial, and anti-protozoal. N-[4-(substituted phenyl)-6-(substituted aryl) pyrimidine-2-yl]-2-[(4H-1,2,4-triazol-4-yl)amino]acetamide(3A-J) were synthesized by different method as cyclization, condensation, purification and crystallization. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral analysis and screened for antibacterial, antifungal, anti-tuberculosis, antimalarial, and anti-protozoal activities. These com-pounds satisfied the bioactive response and simple way for the synthesis.

scholarly journals PHYTOCHEMICAL STUDY OF THE ARIAL PARTS OF Cleome rutidosperma DC PLANT

2010 ◽  
Vol 8 (3) ◽  
pp. 459-462 ◽  
Author(s):  
S. M. Mizanur Rahman ◽  
Serajum Munira ◽  
M. Amzad Hossain
Keyword(s):  
Spectral Analysis ◽  
Carboxylic Acid ◽  
Petroleum Ether ◽  
13C Nmr ◽  
Mass Spectral Data ◽  
Phytochemical Study ◽  
Mass Spectral ◽  
New Compounds ◽  
First Time ◽  
Cleome Rutidosperma

Two new compounds were identified as 2-ethyl-cyclohex-2-ene-6-hydroxy-methylene-1-carboxylic acid and 3b-hydroxy-lup-20(29)-en-28-oic acid, respectively, from the petroleum ether extracts of Cleome rutidosperma plant. These two constituents is the first time occurrence in this plant. The structures of the two different type of compounds are elucidated with the help of UV, IR, 1H-NMR, 13C-NMR, COSY, DEPT 90, DEPT 135 and mass spectral data.   Keywords: Cleome rutidosperm DC; isolation; spectral analysis

scholarly journals S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation

2019 ◽  
Vol 70 (1) ◽  
pp. 13-17
Author(s):  
Stefania-Felicia Barbuceanu ◽  
Octavian Tudorel Olaru ◽  
Laura-Ileana Socea ◽  
Constantin Draghici ◽  
Gabriel Saramet ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Daphnia Magna ◽  
1H Nmr ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Ethyl Bromide ◽  
Phenacyl Bromide ◽  
13C Nmr Spectra ◽  
Ethyl Chloroacetate ◽  
Cytotoxicity Assessment

This paper presents synthesis, characterization and cytotoxicity assessment of six S-alkylated 1,2,4-triazoles derivatives that were obtained by treatment of some 1,2,4-triazole-3-thiones containing in the molecule phenylsulfonylphenyl and propyl or 4-bromophenylsulfonylphenyl and 4-methoxyphenyl fragments with different alkylation agents (ethyl bromide, ethyl chloroacetate or phenacyl bromide) in basic media. The synthesized compounds were physico-chemically characterized and the IR, 1H-NMR, 13C-NMR spectra were consistent with the assigned structures. The cytotoxicity of S-alkylated derivatives was evaluated on Daphnia magna crustacean.

scholarly journals Sintesis Senyawa Turunan Flavanon dan Uji Bioaktivitas Senyawa Kalkon sebagai Senyawa Antara dalam Sintesis Flavanon

2018 ◽  
Vol 8 ◽  
pp. 68-74
Author(s):  
Nur Shidiq ◽  
Agung Rahmadani ◽  
Viriyanata Wijaya ◽  
Laode Rijai
Keyword(s):  
1H Nmr ◽  
Mass Spectroscopy ◽  
13C Nmr ◽  
Brine Shrimp ◽  
Brine Shrimp Lethality

Golongan metabolit sekunder yang memiliki aktivitas biologi sepeti antikanker, antitumor, antiproliferatif, dan antimikroba adalah golongan flavonoid dimana flavanon merupakan salah satu senyawanya. Dalam penelitian ini senyawa 2-hidroksi-5-kloro asetofenon dan 4-hidroksi benzaldehida direaksikan melalui reaksi Kondensasi Claisen-Schmidt menghasilkan senyawa turunan kalkon yaitu 2’-hidroksi-5’-kloro-4-hidroksikalkon. Kemudian senyawa 6-kloro-4’-hidroksi flavanon disintesis melalui reaksi siklisasi turunan kalkon dengan metode refluks menggunakan asam sulfat di dalam etanol sebagai katalis. Senyawa hasil sintesis dikarakterisasi dengan teknik elusidasi struktur menggunakan  1H-NMR, 13C-NMR dan MS (Mass Spectroscopy). Dilakukan uji aktivitas antioksidan dan uji toksisitas dari senyawa 2’-hidroksi-5’-kloro-4-hidroksi kalkon hasil sintesis dengan menggunakan metode DPPH dan metode BSLT (Brine Shrimp Lethality Test) dan dihitung nilai IC50 dan LC50 dengan menggunakan analisis Reed and Muench. Nilai IC50 dan LC50 senyawa 2’-hidroksi-5’-kloro-4-hidroksi kalkon diperoleh 131,19 ppm dan 46,465 ppm

scholarly journals Phytochemical studies on the aerial parts of Sarcococca hookeriana (Baillon) of Nepalese origin

1970 ◽  
Vol 21 ◽  
pp. 8-15
Author(s):  
Narayan P. Rai ◽  
Bimala Lama ◽  
Shiva P. Subedi ◽  
W. C. Taylor ◽  
M. D. Manandhar
Keyword(s):  
Spectral Analysis ◽  
Oleanolic Acid ◽  
1H Nmr ◽  
13C Nmr ◽  
Chemical Society ◽  
Chloroform Extract ◽  
Hmbc Spectrum ◽  
Aerial Parts ◽  
Phytochemical Studies ◽  
First Time

Two known pregnane type of alkaloids, axillaridine A and spiropachysine, and an unidentified pregane alkaloid along with oleanolic acid and stigmasteryl glucoside have been isolated from chloroform extract of the aerial parts of Sarcococca hookeriana. The structures of the alkaloids are established on the basis of spectral analysis of 1H-NMR, 13C-NMR, HMQC, COSY and HMBC spectrum. All compounds were isolated for the first time from S. hookeriana. So far, species of Sarcococca was not reported to contain spiropachysine which was initially reported as a novel alkaloid from Pachysandra terminalis SIEB. et ZUCC.(Buxaceae).DOI: 10.3126/jncs.v21i0.215Journal of Nepal Chemical Society Vol.21 2006 pp.8-15

scholarly journals Ureido Derivatives of Neoabietic Acid

Molbank ◽  
10.3390/m1033 ◽  
2018 ◽  
Vol 2018 (4) ◽  
pp. M1033
Author(s):  
Xinyu Gao ◽  
Niping Feng ◽  
Yuhan Zi ◽  
Jianguo Cao ◽  
Guozheng Huang
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr ◽  
Structure Characterization ◽  
Curtius Rearrangement ◽  
Neoabietic Acid ◽  
Rearrangement Reaction ◽  
Derivatives Of

A series of ureido derivatives of neoabietic acid were synthesized by application of Curtius rearrangement reaction to neoabietic acid and amines. Structure characterization of these compounds was done by 1H-NMR, 13C-NMR and HRMS spectral analysis.

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