scholarly journals STUDY ON APHRODISIAC ACTIVITY OF OLEA DIOICA ROXB. BARK, LEAF EXTRACTS, AND ITS PURE COMPOUND USING WISTAR ALBINO RATS

2017 ◽  
Vol 10 (12) ◽  
pp. 85
Author(s):  
Ashwathanarayana R ◽  
Raja Naika
Keyword(s):  
Bark Extract ◽  
Albino Rats ◽  
Pure Compound ◽  
Leaf Extracts ◽  
Excellent Activity ◽  
Intromission Latency ◽  
Intromission Frequency ◽  
Wistar Albino Rats ◽  
Minor Compounds ◽  
Dose Dependent

Objectives: We aimed to assess the effects of O. dioica Roxb. leaf and bark extract and its isolated constituent benzeneethanol, 4-hydroxy- on aphrodisiac activity in rats using different standard aphrodisiac parameters.Methods: To determine the aphrodisiac activity several parameters were observed. These include measuring and observing the mount frequency (MF), mount latency (ML), intromission frequency (IF), intromission latency (IL), anogenital sniffing (AS), and genital grooming (GG).Results: The aphrodisiac activity of O. dioica Roxb. leaf and bark extracts and its pure compound were studied on Wistar albino rats at different dosages. The parameters observed during the study were MF, ML, IF, IL, AS, and GG. The results revealed that the crude extracts showed dose-dependent activity in all the concentration, in that, ethanolic leaf extract showed excellent activity compared to ethanolic bark extract and pure compound benzene ethanol 4-hydroxy.Conclusion: Results showed the excellent aphrodisiac activity of O. dioica Roxb. leaf and bark ethanolic extracts. However, the major compound benzeneethanol, 4-hydroxy- was not responsible for the aphrodisiac activity, may be the minor compounds even though in minor concentration in the extract influence the sexual activity in tested animals.

EVALUATION OF HEPATOPROTECTIVE EFFECTS OF SELECTED FRUIT PEEL EXTRACTS AND THEIR POLY HERBAL MIXTURE ON CCL4 INDUCED HEPATOTOXICITY: AN IN VIVO STUDY

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (09) ◽  
pp. 67-74
Author(s):  
Gana Manjusha Kondepudi ◽  
Battu Ganga Rao ◽  
P Balakrishnaiah
Keyword(s):  
Hepatoprotective Activity ◽  
Serum Markers ◽  
Albino Rats ◽  
Dependent Manner ◽  
Fruit Peel ◽  
Herbal Mixture ◽  
Wistar Albino Rats ◽  
Dose Dependent ◽  
Peel Extract

The main aim of this study was to screen the selected fruit peel extracts and their polyherbal mixture (PHM) for hepatoprotective activity. Male wistar albino rats (180-200 g), divided into 12 groups after induction of hepatotoxicity, were treated with selected fruit peel extracts and PHM and at the end of 14th day blood and liver samples were collected and analysed. The aqueous peel extract of Malus pumila was a better hepatoprotective among the selected peel extracts. The activities might be due to the conditioning of hepatocytes by protecting the integrity of the membrane from CCl4 induced leakage of serum markers into circulation. All the selected plant extracts and PHM were shown to revert back the liver enzymes to the normal values in diseased rats in a dose dependent manner. In conclusion, the selected fruit peel extracts and poly herbal mixture can be a potent hepatoprotective agent due to their antioxidant and anti-inflammatory actions.

scholarly journals The Neuroprotective and Anti-Inflammatory Effects of Annona Muricata (Graviola) on Radiation-Induced Rat Sciatic Nerve Injury.

2021 ◽  
Author(s):  
Emrah Keskin ◽  
Özlem Elmas ◽  
Havva Hande Keser Şahin ◽  
Çağhan Tönge ◽  
Ahmet Günaydın
Keyword(s):  
Sciatic Nerve ◽  
Ionizing Radiation ◽  
Nerve Injury ◽  
Sciatic Nerve Injury ◽  
Albino Rats ◽  
Annona Muricata ◽  
Leaf Extracts ◽  
Normal Tissues ◽  
Radiation Induced ◽  
Wistar Albino Rats

Abstract Background: In radiotherapy (RT) exposure area, normal tissues are also affected that may cause serious complications in the patients. This study aimed to evaluate Annona muricata’s radioprotective effects on sciatic nerve injury due to ionizing radiation (IR). Methods and Results: 32 adult female Wistar albino rats separated into 4 equal groups; Control (C), Annona muricata leaf extracts (AME), radiation (RAD), radiation and Annona muricata leaf extracts (AME+RAD). In groups AME and AME+RAD, Annona muricata leaf extracts were administered at a dose of 300 mg/kg for the first day and 50 mg/kg everyday for following one week intraperitoneally. In RAD and AME+RAD, rats were exposed to a single dose of 20 Gray IR to their right legs. All the subjects were sacrified at the end of the first month. Oxidative stress biochemical parameters (SOD, CAT and GPx) from blood samples were analyzed. Right sciatic nerves extracted and histomorphology evaluated. Statistically significant vasculature, degenerative and necrotic changes were observed in RAD, compared to C and AME (p<0,01). Swelling in myelin sheath was predominantly seen in RAD. Alterations in the level of CAT (p<0,01), SOD (p<0,01) and GPx (p<0,05) in AME+RAD group compared to RAD group were found to be statistically significant.Conclusion: Our study unveiled that AM could have a potential of biochemically and histomorphology healing on sciatic nerve injury due to ionizing radiation.

scholarly journals Dietary effect of Alstonia Boonei stem bark extract on hematological profiles of Wistar albino rats after inducing oxidative stress with CCl4

2020 ◽  
Vol 02 (04) ◽  
pp. 45
Author(s):  
Robert I. Uroko ◽  
Victor E. Okpashi ◽  
Bayim P.R. Bayim ◽  
Anthony U. Onwuekwe ◽  
Kate M. Ucho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Bark ◽  
Bark Extract ◽  
Albino Rats ◽  
Stem Bark Extract ◽  
Wistar Albino Rats

scholarly journals The Effects of Combined Ethanolic Leaf Extracts of Annona muricata and Artocarpus heterophyllus on Reproductive Parameters of Type 2 Diabetic Wistar Albino Rats

2019 ◽  
pp. 1-8
Author(s):  
F. C. Anacletus ◽  
C. L. Onuah ◽  
K. T. Nwauche
Keyword(s):  
Testosterone Level ◽  
Diabetic Group ◽  
Albino Rats ◽  
Type Ii ◽  
Annona Muricata ◽  
Reproductive Parameters ◽  
Leaf Extracts ◽  
Artocarpus Heterophyllus ◽  
Sperm Density ◽  
Wistar Albino Rats

Aim: The aim of this research is to study the combined effects of the ethanolic leaf extracts of Annona muricata and Artocarpus heterophyllus on the reproductive parameters of type II diabetic wistar albino rats. Materials and Methods: Fifty-six (56) male wistar albino rats were induced with Type II diabetes mellitus using high fat diet and 35 mg/kg body weight streptozotocin (HFD-STZ). Results: The result obtained showed a decreased testosterone level 0.78±.06 ng/ml on the diabetic group while the non-diabetic group had testosterone level of 1.90±.09 ng/ml. Treatment with combined ethanol leaf extract of A. muricata and A. heterophyllus led to a significant (p≤0.05) increase in the testosterone level of the treated groups. The motility, viability and the sperm density were also normalised in the treated groups.The result obtained from the present research showed that combined ethanolic leaf extracts of A. muricata and A. heterophyllus has ameliorative effect of the reproductive parameters of type II diabetic male wistar albino rats.

scholarly journals Hepato-protective potentials of Sterculia setigera stem-bark extract on acetominophen induced hepato toxicity in Wistar albino rats

2018 ◽  
Vol 12 (29) ◽  
pp. 557-562
Author(s):  
M. H. Garba ◽  
M. L. Sherifat ◽  
A. O. Abdul-Majeed ◽  
L. M. Hafsa ◽  
A.B. Awal ◽  
...  
Keyword(s):  
Stem Bark ◽  
Bark Extract ◽  
Albino Rats ◽  
Stem Bark Extract ◽  
Wistar Albino Rats
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