scholarly journals CHEWING GUM: CONFECTIONARY TO A POPULAR TRANSBUCCAL DOSAGE FORM

2017 ◽  
Vol 10 (6) ◽  
pp. 39
Author(s):  
Bharat Jhanwar ◽  
Bhupendra Singh Tomar ◽  
Surajpal Verma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Water Soluble ◽  
Chewing Gum ◽  
Onset Of Action ◽  
Release Studies ◽  
Chewing Gums ◽  
Energy Supplements ◽  
Novel Drug

Chewing gum is a highly convenient and controlled release transbuccal drug delivery system taken without water. It is gaining popularity as a selfadministrable carrier for the medication used for motion sickness, smoke cessation, hypertension, xerostomia, dental caries, pain, as nutritive and energy supplements. Functional chewing gum favors both local and systemic effects intended to be chewed about half an hour. It has emerged out with a fast onset of action either by direct absorption or swallowed with saliva into gastrointestinal tract.It has better bioavailability that lowers the doses and reduces the gastric side-effects. Gums adhere with ease and compliance of administration to children and dysphagia patients. Chewing gums are formulated using a water-insoluble gum base with water-soluble excipients with the active ingredient in the case of medicated gums. European Pharmacopeia standards used for release studies, there are no other particular official standards. It has attracted the researchers as successful potential drug delivery system in coming future. The present article reviews it as novel drug delivery system including its merits and limitations, material and methods of formulation and evaluation.

scholarly journals Medicated chewing gum: An unconventional drug delivery system

1970 ◽  
Vol 1 (4) ◽  
pp. 86-91 ◽  
Author(s):  
Sabera Khatun ◽  
Kumar Bishwajit Sutradhar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Pharmaceutical Journal ◽  
Water Soluble ◽  
Chewing Gum ◽  
Chewing Gums ◽  
Mucosal Drug Delivery

Medicated chewing gum has a history for about a century. Now-a-days it is considered to be a potential and conve-nient modified release drug delivery system which can be used in pain relief medication, smoking cessation, travel illness, freshening of breath, prevention of dental caries, alleviation of xerostomia, vitamin or mineral supplementa-tion etc. Medicated chewing gums are prepared by using a water insoluble gum base with water soluble bulk portion. This formulation offers both local and systemic effects and has a range of advantages over conventional oral solid dosage forms. USP currently has no in vitro release testing apparatus for the evaluation and determination of drug release from the prepared chewing gums. But European Pharmacopoeia adopted a compendial apparatus to do so. Medicated chewing has drawn attention to the researchers as potential drug delivery system and it could be a com-mercial success in near future.Key Words: pharmaceutical chewing gum, gum base, oral mucosal drug delivery, buccal membrane, apparatus.DOI: http://dx.doi.org/10.3329/icpj.v1i4.10064International Current Pharmaceutical Journal 2012, 1(4): 86-91 

scholarly journals Medicated Chewing Gums: Recent Patents and Patented Technology Platforms

2020 ◽  
Vol 13 (3) ◽  
pp. 184-191
Author(s):  
Prerna Kaushik ◽  
Deepak Kaushik
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Oral Route ◽  
Oral Drug ◽  
Chewing Gum ◽  
Technology Platforms ◽  
Conventional Drug ◽  
Chewing Gums

: The reason that the oral route attained such acceptance may be ascribed to its affluence of administration. Over the years, patient convenience- oriented exploration in the area of drug delivery has introduced potential innovative medicine delivery systems. The elegant drug delivery system is an amalgamation of science and dexterity with therapeutic prospect and presentability. It involves the administration of medications in a groundbreaking fashion with the assistance of cosmetics, wearable devices and oral drug delivery system which can also be used for ornamental purposes. Out of which, therapeutic chewing gum offers a highly suitable and amenable technique of dosing medications comprising children and elderlies. It is a potentially convenient means of administering medications either locally or systematically via the oral cavity. It bids innumerable gains over conventional drug delivery methods. Moreover, medicinal chewing gums involve the dynamic and constant masticatory actions for drug release. Currently, enriched expertise has made it promising to advance and fabricate medicated chewing gum with predefined properties and it could be a marketable triumph in the future. Apprehending this, several investigators and pharmaceutical companies are now engaged in developing innovative practices vis-à-vis medicated chewing gums by filing several patents in this area. The present manuscript also delivers a gestalt of various patented technology platforms based on different methods/ mechanisms employed for the preparation of medicated chewing gums.

scholarly journals Review on phytosomes: A novel drug delivery system

2020 ◽  
Vol 13 (1) ◽  
pp. 203-211
Author(s):  
Mahadev B. Khanzode ◽  
Archana D. Kajale ◽  
Madhuri A. Channawar ◽  
Shilpa R. Gawande
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Plant Extracts ◽  
Biological Membrane ◽  
Molecular Complexes ◽  
Water Soluble ◽  
Face Stability ◽  
Degenerative Disorders ◽  
Novel Drug

The term “Phyto” means plant and “some” means cell It is also mentioned as herbosomes this is a new patented technology, where standardized plant extracts or water soluble phytoconstituents are complexed with phospholipids to produce lipid compatible molecular complexes, there by greatly increasing absorption and bioavailability. The recent development and conducted works of various researchers have been studied thoroughly to establish the transdermal route as a potential way to deliver phytoconstituents. Plant derived products or plant extracts are increasingly receiving attention as dietary supplements for the homeostatic management of inflammation, toxicities, cancers, weight loss and other chronic or acute degenerative disorders. But these products frequently face stability and bioavailability problems. Plant products after their isolation become prone to instability and are potentially unfit to cross the bio membrane as such. The phytosome technique reduces these tasks to reasonable extents. The phytosome or Herbosome technique increases the hydrophilicity of highly lipophilic drug there by making it suitable for drug delivery and increases the lipophilicity of hydrophilic phytoconstituents adequately to cross biological membrane. The topical application of phytosomes for cosmetic purpose has already been proven. This review also contains a comparative account of liposomes and phytosomes along with recent advancements in the field of phytosome technology with a special concern to transdermal drug delivery. The poor oral bioavailability of polyphenolic compound can be enhanced through the incorporation of them into phospholipid based self-assembled delivery system, i.e. popularly known as phytosome. There are number of products available in the market that contains phytosomal drug delivery system such as Ginkgo biloba, Silybum marianum, and Camellia sinensis.

A Comprehensive Review On Medicated Chewing Gums- A Novel Drug Delivery System

2020 ◽  
Vol 9 (10) ◽  
pp. 117-120
Author(s):  
Kapil Kumar ◽  
Adesh Sharma ◽  
Deepak Teotia ◽  
Gurleen Kaur
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Comprehensive Review ◽  
Chewing Gums ◽  
Novel Drug Delivery System ◽  
Novel Drug
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