scholarly journals CARDIOPROTECTIVE EFFECT OF VITAMIN E AGAINST MYOCARDIAL INFARCTION INDUCED BY ISOPRENALINE IN ALBINO RATS

2018 ◽  
Vol 11 (6) ◽  
pp. 273
Author(s):  
Abdelbaset Taher Abdelhalim ◽  
Nuruddin Mohammed Nur ◽  
Sherif Mansour ◽  
Abdelnasser Ibrahim
Keyword(s):  
Vitamin E ◽  
Troponin I ◽  
Albino Rats ◽  
Negative Group ◽  
Cardiac Marker ◽  
Once Daily ◽  
Positive Group ◽  
Pretreated Group ◽  
Myocardial Membranes

Objective: Vitamin E is an antioxidant which can help in the prevention of cardiovascular disease. The objective of this study was to estimate the effects of Vitamin E on cardiac marker enzymes in isoprenaline (ISO)-induced myocardial infracted rats.Methods: Adult male albino rats were divided into three groups. The first group was the control negative group. The second group was the control positive group that was subcutaneously injected with ISO (100 mg/kg). The third group was pretreated with Vitamin E (100 mg/kg) once daily for 30 days, then subcutaneously injected with ISO at an interval of 24 h for 2 days. Aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), cardiac troponin-I (CTn-I), glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and histopathological examinations were measured. Comparison between groups was achieved by one-way analysis of variance (ANOVA) test through SPSS software.Results: The levels of AST, ALT, LDH, creatine kinase (CK), and CTn-I significantly decreased in pretreated group with Vitamin E compared to its increasing in the control positive group. The level of GSH and SOD markedly increased in pretreated group with Vitamin E compared to its decreasing in the control positive group, while the level of MDA significantly decreased in pretreated group with Vitamin E compared to its increasing in the control positive group. ISO + Vitamin E rats group reflected a cardioprotective role of Vitamin E in myocardial infarcted rats.Conclusion: Pretreatment with Vitamin E can protect the myocardial membranes against ISO-induced oxidative stress in rats and can be used for routine clinical and epidemiological purposes.

scholarly journals Capillary Deposition of Complement C4d and C3d in Chinese Renal Allograft Biopsies

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Rong Lv ◽  
Wei Zhang ◽  
Fei Han ◽  
Guangjun Liu ◽  
Wenqing Xie ◽  
...  
Keyword(s):  
Survival Rate ◽  
Renal Allograft ◽  
Negative Group ◽  
Term Survival ◽  
Positive Group ◽  
Renal Biopsies ◽  
Alternative Complement ◽  
Complement C4d

Background. C3d is a product of both the classic and the alternative complement cascades; however, few studies have addressed the role of C3d in renal biopsies and its relationship with long-term graft survival rate is not very clear.Methods. 94 patients with biopsy-proven acute rejection episodes were included in the study. We investigated the associations between histological findings, clinical examinations, and outcome.Results. The overall prevalence for C4dPTC and C3dPTC was 42.6% and 29.8%. There was a significant association between C3dPTC and C4dPTC (P<0.001). C3dPTC and C4dPTC were related with histological types (P=0.024andP<0.001, resp.). The long-term survival rate for C4dPTC positive transplants was lower than that of C4dPTC negative transplants, but it was not statistic significant in our study (P=0.150). The survival rate of C3dPTC positive group was much lower than the negative group (P=0.014). Patients with double positives for C4dPTC and C3dPTC exhibited the lowest survival rate significantly different from those of the C3dPTC only and C4dPTC only groups (P=0.01andP=0.0037).Conclusions. This longitudinal cohort study has demonstrated that C3d deposition in the PTC was closely related to renal dysfunction and pathological changes.

scholarly journals Toxicity profile of anticancer drugs in acute lymphoblastic leukemia and protective role of vitamin E on these toxicities in albino rats

2015 ◽  
Vol 1 (1) ◽  
pp. 45
Author(s):  
Regina Roy ◽  
Hema CG ◽  
Geetha N
Keyword(s):  
Clinical Study ◽  
Vitamin E ◽  
Acute Lymphoblastic Leukemia ◽  
Animal Study ◽  
Lymphoblastic Leukemia ◽  
Haematological Toxicity ◽  
Protective Role ◽  
Albino Rats ◽  
Cytostatic Drug

<p class="abstract"><strong>Background:</strong> Objectives:<strong> </strong>(1) To study the spectrum of toxicity due to chemotherapy as per MCP841 protocol during the acute phase of treatment of patients with Acute Lymphoblastic Leukemia (ALL).<strong> </strong>(2) To study the same toxicities in albino rats and the protective role of vitamin E on these toxicities.<strong></strong></p><p class="abstract"><strong>Methods:</strong> This was a prospective clinical study for one year, in the department of medical oncology and paediatric oncology which was augmented by experimental animal study for 5 months using albino rats. For clinical study, patients diagnosed as ALL taking treatment as per MCP841 protocol were taken. Patients were followed up every day to detect the development of any type of adverse reactions or toxicity symptoms. Laboratory tests done during the course of chemotherapy were reviewed for any abnormality. Animal study involved 18 albino rats; rats were divided into 3 Groups; Group 1 - control (n=6), Group 2 - antileukaemic treated rats (n=6), Group 3 - antileukaemic drugs and vitamin-E treated rats (n=6). </p><p class="abstract"><strong>Results:</strong> In the clinical study major toxicities observed were haematological, metabolic, gastrointestinal, general infection, neurotoxicity, pancreatitis, pneumonitis and jaundice. Neurosensory toxicity presented as numbness in the extremities and hyperalgesia and myalgia. Histopathological examination of the internal organs of albino rats studied showed<strong> </strong>protection of vitamin E for the gastric toxicity, pancreatitis, cardiac toxicity, neuro toxicity and hepatic toxicity whereas there was no reduction in splenic and renal toxicities. In the case of haematological toxicity, protection was only minimal.</p><p class="abstract"><strong>Conclusions:</strong> The animal study revealed the protective role of vitamin E on cytostatic drug induced toxicities. </p><strong>Keywords: </strong>Acute lymphoblastic leukaemia (ALL), Antileukaemic drugs, Vitamin E (Vit. E), MCP841 protocol

Service innovation and mental health: The multilevel moderating role of group emotional contagion

2019 ◽  
Vol 47 (10) ◽  
pp. 1-12
Author(s):  
Zhi-Ming Xiao ◽  
Meng-Hsiu Lee ◽  
Hsiao-Chiao Wang
Keyword(s):  
Mental Health ◽  
Service Innovation ◽  
Emotional Contagion ◽  
Mediating Effect ◽  
Negative Group ◽  
Surface Acting ◽  
Positive Group ◽  
The Relationship ◽  
Moderating Role

From the perspective of social information processing theory, we investigated the multilevel mediating effect of surface acting in the relationship between service innovation and frontline employees’ mental health, then further tested the multilevel moderating roles of positive and negative group emotional contagion. We used the experience sampling method to conduct a survey with 572 employees of 71 hospitality and catering companies in China. Hierarchical linear modeling results showed that service innovation negatively affected participants’ mental health via surface acting. Further, positive group emotional contagion positively moderated the relationship between surface acting and mental health. Thus, positive group emotional contagion alleviated the negative influence of surface acting on mental health. The moderating role of negative group emotional contagion was, however, nonsignificant. Theoretical and practical implications of the findings are discussed and recommendations for future research are made.

Assessment of the protective role of vitamin E in atrazine toxicity on the testis of adult albino rats

2014 ◽  
Vol 37 (3) ◽  
pp. 442-452 ◽  
Author(s):  
Shereen A. Elkhateeb ◽  
Nehad F. Mazen ◽  
Osama Y. Ibrahim ◽  
Nermeen R. Abdel-Fattah
Keyword(s):  
Vitamin E ◽  
Protective Role ◽  
Albino Rats
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