scholarly journals ROLE OF HERBAL MEDICINES IN VITILIGO TREATMENT - CURRENT STATUS AND FUTURE PERSPECTIVES

2018 ◽  
Vol 11 (9) ◽  
pp. 19 ◽  
Author(s):  
Radhakrishnan Narayanaswamy ◽  
Intan Safinar Ismail
Keyword(s):  
Herbal Medicines ◽  
Current Status ◽  
Interleukin 17 ◽  
Future Perspectives ◽  
Psoralea Corylifolia ◽  
Necrosis Factor Alpha ◽  
Ammi Visnaga ◽  
Factor Alpha ◽  
Necrosis Factor

Vitiligo is a depigmentation disorder with complex causes. Nonetheless, recent progress has been made to unravel the pathophysiology of vitiligo. In this review, we provide an overview of the currently known herbal medicine for vitiligo treatment and also highlighted the herbs that have been used in clinical trials. In view of traditional uses, herbs such as Ammi visnaga L., Angelica sinensis, Eclipta alba L, Ginkgo biloba, Picrorhiza kurroa Royle Ex Benth, and Psoralea corylifolia L, have been highlighted. Enormous efforts in vitiligo drug discovery are currently needed. Interleukin-17 inhibition, tumor necrosis factor-alpha inhibition, heat shock protein-70i (HSP70i) inhibition, keratinocyte turnover modulators, and regulatory T cells (Tregs) modulators have been discussed as promising new targets for vitiligo drug development. Thus, we strongly believe that this review may be useful for rationalize new herbal drug for vitiligo treatment.

scholarly journals Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110258
Author(s):  
Elsa How Shing Koy ◽  
Pierre Labauge ◽  
Athan Baillet ◽  
Clément Prati ◽  
Hubert Marotte ◽  
...  
Keyword(s):  
Interleukin 17 ◽  
Necrosis Factor Alpha ◽  
Neurologic Diseases ◽  
Tnf Α ◽  
Neuropsychiatric Diseases ◽  
The Central Nervous System ◽  
Factor Alpha ◽  
Inflammatory Drugs ◽  
Necrosis Factor

Tumor necrosis factor alpha (TNF-α) and interleukin-17 (IL-17) are two pro-inflammatory cytokines involved in the pathophysiology of spondyloarthritis (SpA). Therapies targeting TNF-α or IL-17 are used as a second line among SpA patients failing non-steroidal anti-inflammatory drugs. The choice of such treatment has to take into account the patient’s comorbidities. Neurologic diseases are common and their association with SpA deserves to be studied. Therefore, the role of TNF-α and IL-17 cytokines is worth investigating in these neuropsychiatric diseases. This review aimed to explore the role of TNF-α and IL-17 in the pathogenesis of uveitis, multiple sclerosis, neuromyelitis optica, Alzheimer’s disease, Parkinson’s disease and depression. This update is critical to guide the therapeutic management of these co-morbidities in SpA patients.

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