DEVELOPMENT AND IN VITRO EVALUATION OF A NEW TOPICAL O/W EMULGEL FROM FRUIT EXTRACT OF PYRUS COMMUNIS

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2019v11i4.29063 ◽

2019 ◽

pp. 75-79

Author(s):

TANZILA KHILJEE ◽

NAVEED AKHTAR

Keyword(s):

Phase Separation ◽

Droplet Size ◽

Storage Conditions ◽

Pyrus Communis ◽

Gelling Agent ◽

In Vitro Tests ◽

Fruit Extract ◽

Pharmaceutical Dosage Forms ◽

In Vitro Evaluation

Objective: The aim of the present study was to develop a new topical dosage form containing Pyrus communis fruit extract. Developed formulation was O/W Emulgel which was evaluated by its in vitro tests and its stability studies at different storage conditions. Methods: Hydroalcoholic Pyrus communis extract was prepared by the maceration process. A 4% Pyrus communis emulgel was prepared by the combination of emulsion and gel at a specific temperature and mixing through homogenizers. The formulations having different concentration of carbopol 940 (gelling agent) were placed at 8 °C, 25 °C, 40 °C and 40 °C+75%RH for 3 mo in order to find out the most stable formulation. After the selection of final emulgel formulation was eventually further evaluated for in vitro studies such as phase separation, centrifugation, rheology, pH, conductivity, organoleptic properties and mean droplet size over a period of 12 w at 8 °C, 25 °C, 40 °C and 40 °C+75%RH. Results: In vitro evaluation of the selected Pyrus communis emulgel formulation showed good resistance to phase separation on centrifugation, conductivity gradually increases due to oil in water emulgel and pH of formulation was gradually decreased. The rheological behavior was non-Newtonian pseudoplastic and showed shear thinning fluid behavior. Mean droplet size of Pyrus communis emulgel was 16.0±0.20 µm and after 90 d droplet size was 16.7±0.55 µm at high storage temperatures at 40 °C and 40 °C+75RH and no significant changes were observed at normal storage conditions at 8 °C and 25 °C. Conclusion: Pyrus communis emulgel fresh fruit extract showed stable formulation at different storage conditions. This new formulation will be a good addition to pharmaceutical dosage forms made from traditionally used plants.

Download Full-text

FORMULATION AND IN VITRO, IN VIVO EVALUATION OF PRONIOSOMAL GEL OF NEOMYCIN SULPHATE

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019v11i2.30614 ◽

2019 ◽

pp. 156-163

Author(s):

AMOL SHETE ◽

PRIYANKA THORAT ◽

RAJENDRA DOIJAD ◽

SACHIN SAJANE

Keyword(s):

Phase Separation ◽

Skin Irritation ◽

Entrapment Efficiency ◽

Separation Method ◽

Gelling Agent ◽

In Vivo Evaluation ◽

Skin Delivery ◽

Span 60

Objective: The objectives of present investigation were to prepare and evaluate proniosomes of neomycin sulphate (NS) by coacervation phase separation method by using sorbitan monostearate (span 60) and lecithin as a surfactant to increase the penetration through the skin and study the effect of concentration of the same. Methods: Proniosomes of neomycin sulphate (NS) were prepared by coacervation phase separation method by using span 60 and lecithin. The effect of concentration of span 60 and lecithin was studied by factorial design. The prepared proniosomes were converted to gel by using carbopol as a gelling agent. The prepared formulations were evaluated for entrapment efficiency, in vitro drug diffusion, in vitro antibacterial activity and in vivo skin irritation test etc. Results: All Formulation showed the percentage entrapment efficiency in the range 38.31±0.05% to 77.96±0.06%, good homogeneity and gel was easily spreadable with minimal of shear. Optimized formulation showed enhanced rate of diffusion in vitro, increase in zone of inhibition against staphylococcus aureus, no skin irritation and showed good stability. Conclusion: The results of present study indicates that proniosomal gel formulated by using combination of span 60, Lecithin, cholesterol can be used to enhance skin delivery of NS because of excellent permeation of drug. Developed proniosomal gel formulation was promising carrier for NS

Download Full-text

In vitro evaluation of antimicrobial activity and estimation of Epicatechin from the fruit extract of Prunus armeniaca L using HPTLC technique

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.12.04.562 ◽

2020 ◽

Vol 12 (04) ◽

Keyword(s):

Antimicrobial Activity ◽

Prunus Armeniaca ◽

Fruit Extract ◽

In Vitro Evaluation ◽

Prunus Armeniaca L

Download Full-text

RANITIDINE CONTROLLED RELEASE ANTI-REFLUX SUSPENSION FOR GASTRO-OESOPHAGEAL REFLUX DISEASE AND IT’S IN VITRO EVALUATION

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019v11i1.28754 ◽

2019 ◽

Vol 11 (1) ◽

pp. 74

Author(s):

Sangmesh R. Torne ◽

Sheela A. ◽

Sarada N. C.

Keyword(s):

Controlled Release ◽

Reflux Disease ◽

Oesophageal Reflux ◽

Gelling Agent ◽

Acid Neutralizing Capacity ◽

Simulated Gastric Fluid ◽

In Vitro Evaluation ◽

Oesophageal Reflux Disease ◽

Neutralizing Capacity

Objective: The aim of this work was to develop triple action controlled release anti-reflux suspension of ranitidine and its in-vitro evaluation of anti-reflux and controlled release properties.Methods: The formulation was optimized using sodium alginate as a gelling agent along with calcium carbonate, sodium bicarbonate, magnesium hydroxide, aluminium hydroxide as alkalizing agents and colloidal microcrystalline cellulose (MCC) as a suspending agent at various concentrations and arrived at an optimized formulation for its best quality attributes. To avoid initial release in water before administration, ranitidine coated MCC sphere was incorporated into powder formulation and subjected to in vitro characteristics like raft strength, acid neutralizing capacity, pH, viscosity and dissolution study. The obtained results were assessed using Minitab 17 statistical software to conclude the study design.Results: Formulation containing 300 mg of ranitidine along with 750 mg alginate has shown better anti-reflux characteristics like raft strength 18±2g, acid neutralizing capacity 17±1 mEq compared to other formulations. This formulation has also shows zero-order controlled release in the simulated gastric fluid (SGF) up to 10 h compared to the formulation without alginate. Further, to this optimized formulation has shown negligible change in the assay of ranitidine even after 3 mo at 40 °C temperature and 75% RH.Conclusion: The developed stable sustained release powder for suspension has the combined therapeutic efficacy as an antacid and anti-reflux drug suitable for the management and treatment of gastro-oesophageal reflux disease (GERD) unlike the existing drugs possessing only reflux resistance action.

Download Full-text

Biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of Terminalia chebula – In vitro evaluation of anticancer and antimicrobial activity

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2019.02.024 ◽

2019 ◽

Vol 51 ◽

pp. 139-151 ◽

Cited By ~ 11

Author(s):

Bhagavathi Sundaram Sivamaruthi ◽

Vijayan Sri Ramkumar ◽

Govindaraju Archunan ◽

Chaiyavat Chaiyasut ◽

Natarajan Suganthy

Keyword(s):

Antimicrobial Activity ◽

Bimetallic Nanoparticles ◽

Terminalia Chebula ◽

Fruit Extract ◽

Biogenic Synthesis ◽

In Vitro Evaluation ◽

Silver Palladium

Download Full-text

In Vitro Evaluation of the iValve: A Novel Hands-Free Speech Valve

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348941112001207 ◽

2011 ◽

Vol 120 (12) ◽

pp. 814-819 ◽

Cited By ~ 2

Author(s):

Eduard B. van der Houwen ◽

Tjouwke A. van Kalkeren ◽

Johannes G. M. Burgerhof ◽

Bernard F. A. M. van der Laan ◽

Gijsbertus J. Verkerke

Keyword(s):

Free Speech ◽

Low Cost ◽

In Vitro Tests ◽

The Novel ◽

Airflow Resistance ◽

In Vitro Evaluation ◽

Breathing Mode ◽

Pressure Drops ◽

Physiological Values

Objectives: We performed in vitro evaluation of a novel, disposable, automatic hands-free tracheostoma speech valve for laryngectomy patients based upon the principle of inhalation. The commercially available automatic speech valves close upon strong exhalation and open again when the pressure drops. This method makes long sentences or pauses difficult. The novel iValve is designed to allow almost natural speech, with mid-sentence pausing and whispering. Methods: The inhalation closing flows and exhalation opening pressures of 6 iValve prototype versions at different settings were compared with physiological values. The airflow resistance at inhalation was compared to physiological values and to commercial valve values. Results: The iValve prototypes showed flow and pressure ranges in concordance with the physiological values in the literature. The airflow resistance in the breathing mode was within the physiological airflow resistance range, yet above the values from the two commercial valves. The resistance in the speaking mode was above the physiological airflow resistance range. Conclusions: In vitro tests show that the iValve versions can be selected and adjusted to operate within the physiological range. The airflow resistance in the breathing mode is good. In speaking mode, inhalation should, and can, be decreased. The iValve should offer the patient a more intuitively useable alternative with more dynamic speech. Its low cost allows disposability and wider use.

Download Full-text